8-bromo-3-fluoroquinoline-2-carboxylic acid | 834884-11-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-bromo-3-fluoroquinoline-2-carboxylic acid
• 英文别名: 2-Quinolinecarboxylic acid, 8-bromo-3-fluoro-
• CAS: 834884-11-6
• 化学式: C₁₀H₅BrFNO₂
• 分子量: 270.058
• InChiKey: WPTLONOUZZSGJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  8-溴-3-氟喹啉-2(1H)-酮 在 正丁基锂 、 三溴氧磷 作用下， 以 正己烷 、 甲苯 为溶剂， 反应 1.25h， 生成 8-bromo-3-fluoroquinoline-2-carboxylic acid
  参考文献：
  名称：

  Metalation/functionalization sequences applied to 2-bromo-3-fluoroquinolines

  摘要：

  Mono- and disubstituted 2-bromo-3-fluoroquinotines 3 are readily accessible. They can be converted into the 3-fluoroquinoline-2-carboxylic acids 5 by consecutive halogen/metal permutation and into the 2-bromo-3-fluoroquinoline-4-carboxylic acids 6 by consecutive deprotonation and carboxylation. The latter compounds can be reduced to afford the 3-fluoroquinoline-4-carboxylic acids 7. The yields are excellent throughout. Rather than to introduce one functional group alternatively at the 2- or 4-position, one may also attach two different functional groups sequentially to both sites. (C) 2004 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2004.10.053

文献信息

• Metalation/functionalization sequences applied to 2-bromo-3-fluoroquinolines
  作者：Levente Ondi、Jean-Noël Volle、Manfred Schlosser

  DOI：10.1016/j.tet.2004.10.053

  日期：2005.1

  Mono- and disubstituted 2-bromo-3-fluoroquinotines 3 are readily accessible. They can be converted into the 3-fluoroquinoline-2-carboxylic acids 5 by consecutive halogen/metal permutation and into the 2-bromo-3-fluoroquinoline-4-carboxylic acids 6 by consecutive deprotonation and carboxylation. The latter compounds can be reduced to afford the 3-fluoroquinoline-4-carboxylic acids 7. The yields are excellent throughout. Rather than to introduce one functional group alternatively at the 2- or 4-position, one may also attach two different functional groups sequentially to both sites. (C) 2004 Published by Elsevier Ltd.