2,3-dimethyl 4-isopropyl quinoline-2,3,4-tricarboxylate | 1221405-86-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,3-dimethyl 4-isopropyl quinoline-2,3,4-tricarboxylate
• 英文别名: 2-O,3-O-dimethyl 4-O-propan-2-yl quinoline-2,3,4-tricarboxylate
• CAS: 1221405-86-2
• 化学式: C₁₇H₁₇NO₆
• 分子量: 331.325
• InChiKey: RGNUGFYCWVGBJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  91.8
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  靛红 、 丁炔二酸二甲酯 、 异丙醇 在 二硫化碳 、 sodium hydride 作用下， 以 乙腈 为溶剂， 反应 4.0h， 以82%的产率得到2,3-dimethyl 4-isopropyl quinoline-2,3,4-tricarboxylate
  参考文献：
  名称：

  Formation of trialkyl quinoline-2,3,4-tricarboxylates by reaction of isatin, dialkyl acetylenedicarboxylates, and sodium O-alkyl carbonodithioates

  摘要：

  An efficient one-pot synthesis of quinoline-2,3,4-tricarboxylates is described by reaction of isatin (indoline-2,3-dione) and electron-deficient acetylenic esters in the presence of sodium O-alkyl carbonodithioates, themselves prepared by addition of sodium hydride to a solution of an alcohol in CS2. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2010.02.107

文献信息

• Formation of trialkyl quinoline-2,3,4-tricarboxylates by reaction of isatin, dialkyl acetylenedicarboxylates, and sodium O-alkyl carbonodithioates
  作者：Issa Yavari、Samereh Seyfi、Zinatossadat Hossaini

  DOI：10.1016/j.tetlet.2010.02.107

  日期：2010.4

  An efficient one-pot synthesis of quinoline-2,3,4-tricarboxylates is described by reaction of isatin (indoline-2,3-dione) and electron-deficient acetylenic esters in the presence of sodium O-alkyl carbonodithioates, themselves prepared by addition of sodium hydride to a solution of an alcohol in CS2. (C) 2010 Published by Elsevier Ltd.