α-iodocyclodecane-2,6-dione | 854596-16-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: α-iodocyclodecane-2,6-dione
• 英文别名: 6-Iodocyclodecane-1,5-dione；6-iodocyclodecane-1,5-dione
• CAS: 854596-16-0
• 化学式: C₁₀H₁₅IO₂
• 分子量: 294.132
• InChiKey: QCMYYOFROYVTMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  α-iodocyclodecane-2,6-dione 在 偶氮二异丁腈 、 三正丁基氢锡 作用下， 以 苯 为溶剂， 以79%的产率得到Cyclodecane-1,5-dione
  参考文献：
  名称：

  Efficient access to functionalised medium-ring systems by radical fragmentation/radical addition to α-iodoketones

  摘要：

  Functionalised medium-ring systems of various sizes can be efficiently prepared by a novel approach that embodies a radical-induced fragmentation of bicyclic P-hydroxy ketones, followed by a second radical-coupling reaction. The unexpected reactivity of ot-keto radicals is also discussed. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.03.200
• 作为产物：
  描述：

  cis-6-hydroxybicyclo<4.4.0>decan-2-one 在 碘 、 mercury(II) oxide 作用下， 以 四氯化碳 为溶剂， 反应 2.0h， 以93%的产率得到α-iodocyclodecane-2,6-dione
  参考文献：
  名称：

  Efficient access to functionalised medium-ring systems by radical fragmentation/radical addition to α-iodoketones

  摘要：

  Functionalised medium-ring systems of various sizes can be efficiently prepared by a novel approach that embodies a radical-induced fragmentation of bicyclic P-hydroxy ketones, followed by a second radical-coupling reaction. The unexpected reactivity of ot-keto radicals is also discussed. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.03.200

文献信息

• Efficient access to functionalised medium-ring systems by radical fragmentation/radical addition to α-iodoketones
  作者：Corinne De Dobbeleer、Ali Ates、Jean-Christophe Vanherk、István E. Markó

  DOI：10.1016/j.tetlet.2005.03.200

  日期：2005.5

  Functionalised medium-ring systems of various sizes can be efficiently prepared by a novel approach that embodies a radical-induced fragmentation of bicyclic P-hydroxy ketones, followed by a second radical-coupling reaction. The unexpected reactivity of ot-keto radicals is also discussed. (c) 2005 Elsevier Ltd. All rights reserved.