N-(4-(1,2,3,4,5,6,7,8,9,10-decahydro-3,3,6,6-tetramethyl-1,8-dioxoacridin-9yl)phenyl)acetamide | 392722-30-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(4-(1,2,3,4,5,6,7,8,9,10-decahydro-3,3,6,6-tetramethyl-1,8-dioxoacridin-9yl)phenyl)acetamide
• 英文别名: N-[4-(3,3,6,6-tetramethyl-1,8-dioxo-2,4,5,7,9,10-hexahydroacridin-9-yl)phenyl]acetamide
• CAS: 392722-30-4
• 化学式: C₂₅H₃₀N₂O₃
• 分子量: 406.525
• InChiKey: UEGBANYAKOJYOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  30
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  75.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对乙酰氨基苯甲醛 、 5,5-二甲基-1,3-环己二酮 在 ammonium acetate 作用下， 反应 0.25h， 以75%的产率得到N-(4-(1,2,3,4,5,6,7,8,9,10-decahydro-3,3,6,6-tetramethyl-1,8-dioxoacridin-9yl)phenyl)acetamide
  参考文献：
  名称：

  MCM-41-SO3H as a nanoreactor for the one-pot, solvent-free synthesis of 1,8-dioxo-9-aryl decahydroacridines

  摘要：

  AbstractOne‐pot four‐component synthesis of 1,8‐dioxo‐9‐aryl decahydroacridines in solvent‐free condition was efficiently performed in the presence of MCM‐41‐SO3H as a nanocatalyst and nanoreactor in good yields. The method provides several advantages such as low cost, operational and experimental simplicity, high yields, and short reaction times. J. Heterocyclic Chem., (2012).

  DOI：

  10.1002/jhet.692

文献信息

• MCM-41-SO3H as a nanoreactor for the one-pot, solvent-free synthesis of 1,8-dioxo-9-aryl decahydroacridines
  作者：Shahnaz Rostamizadeh、Asiyeh Amirahmadi、Nasrin Shadjou、Ali M. Amani

  DOI：10.1002/jhet.692

  日期：2012.1

  AbstractOne‐pot four‐component synthesis of 1,8‐dioxo‐9‐aryl decahydroacridines in solvent‐free condition was efficiently performed in the presence of MCM‐41‐SO3H as a nanocatalyst and nanoreactor in good yields. The method provides several advantages such as low cost, operational and experimental simplicity, high yields, and short reaction times. J. Heterocyclic Chem., (2012).