2,2,5-trimethyl-1,3-dioxin-4-one | 110168-51-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2,5-trimethyl-1,3-dioxin-4-one
• 英文别名: 2,2,5-Trimethyl-2H,4H-1,3-dioxin-4-one
• CAS: 110168-51-9
• 化学式: C₇H₁₀O₃
• 分子量: 142.155
• InChiKey: LOTZEUSHKCAQNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-甲基-3-氧代丙酸叔丁酯 、 丙酮 在 硫酸 、 乙酸酐 作用下， 反应 1.0h， 以18%的产率得到2,2,5-trimethyl-1,3-dioxin-4-one
  参考文献：
  名称：

  Sato, Masayuki; Yoneda, Naoki; Kaneko, Chikara, Chemical and pharmaceutical bulletin, 1986, vol. 34, # 11, p. 4577 - 4584

  摘要：

  DOI：

文献信息

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  申请人：Boyle George Robert

  公开号：US20050245563A1

  公开（公告）日：2005-11-03

  Disclosed are novel inhibitors of Chk-1 and methods of using the same for therapy.

  本发明涉及一种新的Chk-1抑制剂及其治疗方法。
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  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0483420A1

  公开（公告）日：1992-05-06

  A coating composition which cures at ambient temperatures and contains 20-80% by weight of a binder and 80-20% by weight of a solvent for the binder, wherein the binder contains about: A. 60-80% by weight, based on the weight of the binder, of an acrylic polymer A of polymerized monomers of methyl methacrylate and monomers of styrene, alkyl methacrylate and/or alkyl acrylate each having 2-12 carbon atoms in the alkyl group and said polymer having pending from the polymer backbone aminoester groups, hydroxy aminoester groups or hydroxyamine groups, B. 20-40% by weight, based on the weight of the binder, of an acrylic crosslinking polymer B of polymerized monomers of at least 3% by weight, based on the weight of the crosslinking polymer, of a glycidyl constituent of glycidyl methacrylate or acrylate, at least 5% by weight, based on the weight of the crosslinking polymer, of an alkyl methacrylate or acrylate having a pendent group of the formula and the remainder of the monomers are alkyl methacrylate an acrylate each having 1-12 carbon atoms in the alkyl group; the composition is useful as an exterior finish for automobiles and trucks and for repairing and finishes of automobiles and trucks.

  一种在环境温度下固化的涂料组合物，含有 20-80%（重量）的粘结剂和 80-20%（重量）的粘结剂溶剂，其中粘结剂含有约： A.以粘结剂重量为基准，60-80%（重量）的丙烯酸聚合物 A，由甲基丙烯酸甲酯单体和苯乙烯单体、甲基丙烯酸烷基酯和/或丙烯酸烷基酯单体聚合而成，每种单体的烷基中都有 2-12 个碳原子，所述聚合物的聚合物骨架上还有氨基酯基团、羟基氨基酯基团或羟基胺基团、 B.以粘合剂重量计，20-40%(重量)的丙烯酸交联聚合物 B 的聚合单体，以交联聚合物重量计，至少 3%(重量)的甲基丙烯酸缩水甘油酯或丙烯酸缩水甘油酯的缩水甘油酯成分，以交联聚合物重量计，至少 5%(重量)的甲基丙烯酸烷基酯或丙烯酸烷基酯，其具有式中的悬垂基团 其余单体为甲基丙烯酸烷基酯和丙烯酸烷基酯，每个烷基中含有 1-12 个碳原子；该组合物可用作汽车和卡车的外部饰面，也可用于汽车和卡车的维修和饰面。
• Coating composition of acrylic polymers containing reactive groups and an epoxy organosilane
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0494481A1

  公开（公告）日：1992-07-15

  A coating composition which cures at ambient temperatures and contains 20-80% by weight of a binder and 80-20% by weight of a solvent for the binder, wherein the binder contains about: A. an acrylic polymer A of polymerized monomers of methyl methacrylate and monomers of styrene, alkyl methacrylate and/or alkyl acrylate each having 2-12 carbon atoms in the alkyl group and said polymer having pending from the polymer backbone aminoester groups, hydroxy aminoester groups or hydroxyamine groups, B. an acrylic crosslinking polymer B of polymerized monomers of at least 3% by weight, based on the weight of the crosslinking polymer, of a glycidyl constituent of glycidyl methacrylate or acrylate and the remainder of the monomers are alkyl methacrylate an acrylate each having 1-12 carbon atoms in the alkyl group and optionally contains at least 3% by weight, based on the weight of the crosslinking polymer, of an alkyl methacrylate or acrylate having a pendent group of the formula C. an organosilane compound having an epoxy group; the composition is useful as an exterior finish for automobiles and trucks and for repairing and finishes of automobiles and trucks.

  一种在环境温度下固化的涂料组合物，含有 20-80%（重量）的粘结剂和 80-20%（重量）的粘结剂溶剂，其中粘结剂含有约： A. 由甲基丙烯酸甲酯单体和苯乙烯单体、甲基丙烯酸烷基酯和/或丙烯酸烷基酯单体聚合而成的丙烯酸聚合物 A，每种单体的烷基中都有 2-12 个碳原子，所述聚合物的聚合物骨架上还有氨基酯基团、羟基氨基酯基团或羟基胺基团、 B. 丙烯酸交联聚合物 B，其聚合单体中至少有 3%（以交联聚合物重量计）的缩水甘油 成分，即甲基丙烯酸缩水甘油酯或丙烯酸酯，其余单体为甲基丙烯酸烷基酯和丙烯酸烷基酯， 每个烷基中含有 1-12 个碳原子，还可选择含有至少 3%（以交联聚合物重量计）的甲 基丙烯酸烷基酯或丙烯酸烷基酯，该烷基酯或丙烯酸烷基酯具有以下式子的悬垂基团： 1. C. 具有环氧基团的有机硅化合物； 该组合物可用作汽车和卡车的外部饰面，也可用于汽车和卡车的维修和饰面。
• Cellulose ester and ethylene vinyl acetate compositions and articles made using these compositions
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  公开号：US11034820B2

  公开（公告）日：2021-06-15

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  纤维素酯组合物由至少一种纤维素酯和至少一种抗冲改性剂以及可选的至少一种增塑剂组成。此外，还提供了纤维素酯组合物的生产工艺以及使用这些组合物制成的物品，如眼镜架、汽车零件和玩具。