[(1R,13S,14S,15S,16R,17S)-14,16-diacetyloxy-9-hydroxy-11-oxo-19-sulfanylidene-5,7,18,20-tetraoxa-12-azapentacyclo[11.7.0.01,17.02,10.04,8]icosa-2,4(8),9-trien-15-yl] acetate | 935853-67-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 石蒜科生物碱
• 英文名称: [(1R,13S,14S,15S,16R,17S)-14,16-diacetyloxy-9-hydroxy-11-oxo-19-sulfanylidene-5,7,18,20-tetraoxa-12-azapentacyclo[11.7.0.01,17.02,10.04,8]icosa-2,4(8),9-trien-15-yl] acetate
• CAS: 935853-67-1
• 化学式: C₂₁H₁₉NO₁₂S
• 分子量: 509.447
• InChiKey: UONBPPYYONIKQF-NGOAJHFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  197
• 氢给体数：
  2
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  [(1R,13S,14S,15S,16R,17S)-14,16-diacetyloxy-9-hydroxy-11-oxo-19-sulfanylidene-5,7,18,20-tetraoxa-12-azapentacyclo[11.7.0.01,17.02,10.04,8]icosa-2,4(8),9-trien-15-yl] acetate 在 偶氮二异丁腈 、 三正丁基氢锡 、 potassium carbonate 作用下， 以 甲醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 32.0h， 生成 10b(S)-epipancratistatin
  参考文献：
  名称：

  Antineoplastic Agents. 550. Synthesis of 10b(S)-Epipancratistatin from (+)-Narciclasine^,1

  摘要：

  By means of a five-step reaction sequence, narciclasine (2a), isolated from Narcissus sp., was converted to 10b(S)-epipancratistatin (3a) in 5.7% overall yield. The key step entailed a radical-initiated 10b,1 C-O cleavage employing tributyltin hydride to yield a B/C cis ring juncture (3b). Biological evaluation of 10b(S)-epipancratistatin (3a) provided evidence that antineoplastic activity was reduced by a factor of 10 when the B/C trans juncture was replaced with a B/C cis ring juncture.

  DOI：

  10.1021/np068046e
• 作为产物：
  描述：

  水仙环素 在 四氧化锇 、 Hydroquinone 1,4-phthalazinediyl diether 、 N-甲基吗啉氧化物 作用下， 以 吡啶 、 水 、 N,N-二甲基甲酰胺 、 丁酮 为溶剂， 反应 70.0h， 生成 [(1R,13S,14S,15S,16R,17S)-14,16-diacetyloxy-9-hydroxy-11-oxo-19-sulfanylidene-5,7,18,20-tetraoxa-12-azapentacyclo[11.7.0.01,17.02,10.04,8]icosa-2,4(8),9-trien-15-yl] acetate
  参考文献：
  名称：

  Antineoplastic Agents. 550. Synthesis of 10b(S)-Epipancratistatin from (+)-Narciclasine^,1

  摘要：

  By means of a five-step reaction sequence, narciclasine (2a), isolated from Narcissus sp., was converted to 10b(S)-epipancratistatin (3a) in 5.7% overall yield. The key step entailed a radical-initiated 10b,1 C-O cleavage employing tributyltin hydride to yield a B/C cis ring juncture (3b). Biological evaluation of 10b(S)-epipancratistatin (3a) provided evidence that antineoplastic activity was reduced by a factor of 10 when the B/C trans juncture was replaced with a B/C cis ring juncture.

  DOI：

  10.1021/np068046e

文献信息

• Antineoplastic Agents. 550. Synthesis of 10b(<i>S</i>)-Epipancratistatin from (+)-Narciclasine^,1
  作者：George R. Pettit、Noeleen Melody、Delbert L. Herald、John C. Knight、Jean-Charles Chapuis

  DOI：10.1021/np068046e

  日期：2007.3.1

  By means of a five-step reaction sequence, narciclasine (2a), isolated from Narcissus sp., was converted to 10b(S)-epipancratistatin (3a) in 5.7% overall yield. The key step entailed a radical-initiated 10b,1 C-O cleavage employing tributyltin hydride to yield a B/C cis ring juncture (3b). Biological evaluation of 10b(S)-epipancratistatin (3a) provided evidence that antineoplastic activity was reduced by a factor of 10 when the B/C trans juncture was replaced with a B/C cis ring juncture.