(R)-3-Hydroxy-hexanal | 125763-48-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-3-Hydroxy-hexanal
• 英文别名: (3R)-3-hydroxyhexanal
• CAS: 125763-48-6
• 化学式: C₆H₁₂O₂
• 分子量: 116.16
• InChiKey: JVDKSPFKTRMHMA-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  乙醛 、 正丁醛 在 deoxyribose-phosphate aldolase 三乙醇胺 、 乙二胺四乙酸 作用下， 生成 (R)-3-Hydroxy-hexanal
  参考文献：
  名称：

  Deoxyribose-5-phosphate aldolase as a synthetic catalyst

  摘要：

  DOI：

  10.1021/ja00161a064

文献信息

• NOVEL TRANSFORMANT AND PROCESS FOR PRODUCING POLYESTER BY USING THE SAME
  申请人：Kaneka Corporation

  公开号：EP1726637A1

  公开（公告）日：2006-11-29

  The present invention provides a process for producing yeast excellent in cell productivity and gene manipulation of which is easy, being added with nutritional requirement by disrupting only a specific gene, and a transformant thereof. Moreover, the present invention also provides a process for producing a gene expression product, particularly a polyhydroxyalkanoic acid. In the present invention, yeast in which a plurality of genes is disrupted is produced using the homologous recombination. Moreover, a transformant is obtained by introducing a plurality of enzyme genes involved with polyhydroxyalkanoic acid synthesis such as a polyhydroxyalkanoic acid synthase gene and an acetoacetyl CoA reductase gene into said gene-disrupted yeast. Furthermore, said transformant is cultured, copolyesters comprising a polyhydroxyalkanoic acid are efficiently accumulated within the cells, and a polymer is harvested from the cultured product.

  本发明提供了一种生产酵母的工艺，这种酵母细胞生产率高，基因操作简单，只需破坏一个特定的基因，就能增加营养需求，本发明还提供了一种其转化体。此外，本发明还提供了一种生产基因表达产物，特别是多羟基烷酸的工艺。 在本发明中，使用同源重组法生产出多个基因被破坏的酵母。此外，通过将参与多羟基烷酸合成的多个酶基因（如多羟基烷酸合成酶基因和乙酰乙酰辅酶还原酶基因）导入所述基因被破坏的酵母中，可获得转化体。此外，培养所述转化体，在细胞内有效积累包含聚羟基烷酸的共聚多酯，并从培养产物中收获聚合物。
• Transgenic systems for the manufacture of poly(3-hydroxy-butyrate-CO-3-hydroxyhexanoate)
  申请人：METABOLIX, INC.

  公开号：EP2088198A2

  公开（公告）日：2009-08-12

  Methods for engineering transgenic organisms that synthesize polyhydroxyalkanoates (PHAs) containing 3-hydroxyhexanoate as comonomer have been developed. These processes are based on genetically engineered bacteria such as Escherichia coli or in plant crops as production systems which include PHA biosynthetic genes from PHA producers. In a preferred embodiment of the method, additional genes are introduced in wild type or transgenic polyhydroxybutyrate (PHB) producers, thereby creating new strains that synthesize 3HH monomers which are incorporated into PHAs. The 3HH monomer preferably is derived in microbial systems using butanol or butyrate as feedstocks, which are precursors of 3-hydroxyhexanoyl-CoA. Pathways for in vivo production of butyrol-CoA specifically encompassing butyryl-CoA dehydrogenase activity are provided.

  目前已开发出可合成以 3-hydroxyhexanoate 为单体的聚羟基烷酸酯（PHA）的转基因生物的工程方法。这些方法以基因工程细菌（如大肠杆菌）为基础，或以植物作物为生产系统，其中包括来自 PHA 生产者的 PHA 生物合成基因。在该方法的一个优选实施方案中，在野生型或转基因聚羟基丁酸（PHB）生产者中引入额外的基因，从而产生合成 3HH 单体的新菌株，这些单体被掺入 PHA 中。3HH 单体最好在以丁醇或丁酸为原料的微生物系统中产生，它们是 3-hydroxyhexanoyl-CoA 的前体。提供了体内生产丁酰-CoA 的途径，特别是包含丁酰-CoA 脱氢酶活性的途径。
• TRANSGENIC SYSTEMS FOR THE MANUFACTURE OF POLY(2-HYDROXY-BUTYRATE-CO-3-HYDROXYHEXANOATE)
  申请人：——

  公开号：US20020040485A1

  公开（公告）日：2002-04-04

  Methods for engineering transgenic organisms that synthesize polyhydroxyalkanoates (PHAs) containing 3-hydroxyhexanoate as comonomer have been developed. These processes are based on genetically engineered bacteria such as Escherichia coli or in plant crops as production systems which include PHA biosynthetic genes from PHA producers. In a preferred embodiment of the method, additional genes are introduced in wild type or transgenic polyhydroxybutyrate (PHB) producers, thereby creating new strains that synthesize 3HH monomers which are incorporated into PHAs. The 3HH monomer preferably is derived in microbial systems using butanol or butyrate as feedstocks, which are precursors of 3-hydroxyhexanoyl-CoA. Pathways for in vivo production of butyrol-CoA specifically encompassing butyryl-CoA dehydrogenase activity are provided.

  目前已开发出可合成以 3-羟基己酸酯为共聚单体的聚羟基烷酸酯（PHA）的转基因生物工程学方法。这些工艺基于基因工程细菌，如 大肠杆菌 或植物作物作为生产系统，其中包括来自 PHA 生产者的 PHA 生物合成基因。在该方法的一个优选实施方案中，在野生型或转基因聚羟基丁酸（PHB）生产者中引入额外的基因，从而产生合成 3HH 单体的新菌株，这些单体被掺入 PHA 中。3HH 单体最好在以丁醇或丁酸为原料的微生物系统中产生，它们是 3-hydroxyhexanoyl-CoA 的前体。提供了体内生产丁酰-CoA 的途径，特别是包含丁酰-CoA 脱氢酶活性的途径。
• TRANSGENIC SYSTEMS FOR THE MANUFACTURE OF POLY(3-HYDROXY -BUTYRATE -CO -3- HYDROXYHEXANOATE)
  申请人：METABOLIX, INC.

  公开号：EP1208208A2

  公开（公告）日：2002-05-29
• Transgenic systems for the manufacture of poly(2-hydroxy-butyrate-co-3-hydroxyhexanoate)
  申请人：Metabolix, Inc.

  公开号：US20040172675A1

  公开（公告）日：2004-09-02

  Methods for engineering transgenic organisms that synthesize polyhydroxyalkanoates (PHAs) containing 3-hydroxyhexanoate as comonomer have been developed. These processes are based on genetically engineered bacteria such as Escherichia coli or in plant crops as production systems which include PHA biosynthetic genes from PHA producers. In a preferred embodiment of the method, additional genes are introduced in wild type or transgenic polyhydroxybutyrate (PHB) producers, thereby creating new strains that synthesize 3HH monomers which are incorporated into PHAs. The 3HH monomer preferably is derived in microbial systems using butanol or butyrate as feedstocks, which are precursors of 3-hydroxyhexanoyl-CoA. Pathways for in vivo production of butyrol-CoA specifically encompassing butyryl-CoA dehydrogenase activity are provided.