D-葡萄糖酸 | 131797-36-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: D-葡萄糖酸
• 英文名称: 2,3,4,5,6-penta-O-acetyl-D-gluconate
• 英文别名: D-gluconic acid methyl ester；D-Gluconsaeure-methylester；Methyl gluconate；methyl (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
• CAS: 131797-36-9
• 化学式: C₇H₁₄O₇
• 分子量: 210.184
• InChiKey: XKJLTJCYZRLXMM-ARQDHWQXSA-N

物化性质

• 沸点：
  511.3±50.0 °C(Predicted)
• 密度：
  1.538±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  127
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  D-葡萄糖酸 、 三氟乙酸酐 生成 methyl (2R,3S,4S,5R)-2,3,4,5,6-pentakis[(2,2,2-trifluoroacetyl)oxy]hexanoate
  参考文献：
  名称：

  KONIG, WILFRIED A.;LUTZ, SABINE;WENZ, GERHARD, ANGEW. CHEM., 100,(1988) N, C. 989-990

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl 6-deoxy-6-iodo-2,3,4,5-tetra-O-acetyl-D-gluconate 在 sodium acetate 作用下， 以 六甲基磷酰三胺 为溶剂， 生成 D-葡萄糖酸
  参考文献：
  名称：

  Unexpected outcome in the reaction of sugar lactones with iodotrimethylsilane

  摘要：

  The reaction of iodotrimethylsilane with sugar lactones protected by ester groups leads to primary iodides of the same configuration.

  DOI：

  10.1016/s0040-4039(00)73521-0

文献信息

• [EN] PHENOTHIAZINE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE PHÉNOTHIAZINE ET LEURS UTILISATIONS
  申请人：CAMP4 THERAPEUTICS CORP

  公开号：WO2019195789A1

  公开（公告）日：2019-10-10

  The present invention provides phenothiazine compounds, processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment of various diseases or conditions, for example ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA).

  本发明提供了吩噻嗪化合物，其制备方法，包含该化合物的药物组合物，以及在治疗各种疾病或症状中使用该化合物或组合物，例如核糖体紊乱和核糖体病，例如钻石-布莱克范贫血（DBA）。
• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• Functionally Diverse Macromolecules and Their Synthesis
  申请人：Simanek E. Eric

  公开号：US20070041933A1

  公开（公告）日：2007-02-22

  Functionally diverse macromolecules and synthetic routes for obtaining the same are disclosed. In certain embodiments, the synthesis proceeds in a divergent manner. In other embodiments, the routes rely on the differential reactivity of monomeric electrophilic triazine building blocks that display protected or unprotected groups. This diversity permits the facile introduction of a variety of diversity groups at multiple positions of these macromolecules, thereby setting the stage for further generational growth of the macromolecule and/or incorporation of other diversity groups such as biocompatible targeting groups.

  本文披露了功能多样的大分子和用于获得这些大分子的合成途径。在某些实施例中，合成以分散的方式进行。在其他实施例中，这些途径依赖于显示受保护或未受保护基团的单体亲电性三嗪构建块的不同反应性。这种多样性使得能够轻松地在这些大分子的多个位置引入各种多样性基团，从而为大分子的进一步世代生长和/或其他多样性基团（如生物相容性靶向基团）的引入奠定了基础。
• COSMETIC COMPOSITIONS WITH TRICYCLODECANE AMIDES
  申请人：Conopco, Inc., d/b/a UNILEVER

  公开号：US20160008249A1

  公开（公告）日：2016-01-14

  The invention is directed to a cosmetic composition and the precursor thereof. The composition has solid agent and liquid agent, both of which are cosmetic benefit ingredients. The solubility of solid agents in liquid agents in the inventive compositions is enhanced in the presence of a tricyclodecane amide.

  该发明涉及一种化妆品组合物及其前体。该组合物具有固体剂和液体剂，两者均为化妆品益处成分。在创新组合物中，固体剂在液体剂中的溶解性在三环十二碳酰胺的存在下得到增强。
• HYDROXYTYROSOL DERIVATIVES, THEIR METHOD OF PREPARATION AND USE IN PERSONAL CARE
  申请人：Eastman Chemical Company

  公开号：US20150126759A1

  公开（公告）日：2015-05-07

  Hydroxytyrosol derivative compositions, methods for their manufacture, and their use in personal care products are disclosed. Lipophilic hydroxytyrosol carbonate ester compound can be made by oxidizing a substituted hydroxybenzaldehyde compound with an oxidizing agent such as hydrogen peroxide under mild conditions. The process involves enzymatic esterification of 4-(2-hydroxyethyl)phenol to form the corresponding ester, the introduction of a formyl group ortho to the phenolic hydroxyl group of the ester to form a lipophilic formyltyrosol ester; oxidation of the lipophilic formyltyrosol ester with a peroxide compound to form a lipophilic hydroxytyrosol ester compound; and reaction of lipophilic hydroxytyrosol ester compound with carbonic acid ester derivatives to form a lipophilic hydroxytyrosol carbonic ester compound. These compounds are useful is a wide variety of personal care compositions as anti-aging compounds that are stable against oxidation.

  披露了羟基酪醇衍生物组合物的制造方法，以及它们在个人护理产品中的应用。脂溶性羟基酪醇碳酸酯化合物可以通过将取代羟基苯甲醛化合物与氧化剂（如过氧化氢）在温和条件下氧化而制得。该过程涉及酶催化的4-(2-羟乙基)酚酯化反应，形成相应的酯化物，将羟基酯的酚羟基正对位引入一个甲酰基，形成一个脂溶性甲酰酪醇酯；将脂溶性甲酰酪醇酯与过氧化物化合物氧化，形成脂溶性羟基酪醇酯化合物；以及将脂溶性羟基酪醇酯化合物与碳酸酯衍生物反应，形成脂溶性羟基酪醇碳酸酯化合物。这些化合物对于各种个人护理产品都很有用，作为抗衰老化合物，具有抗氧化稳定性。