1-(2,6-Dimethoxypyrimidin-4-yl)propan-2-one | 1071143-97-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2,6-Dimethoxypyrimidin-4-yl)propan-2-one
• 英文别名: 1-(2,6-dimethoxypyrimidin-4-yl)propan-2-one
• CAS: 1071143-97-9
• 化学式: C₉H₁₂N₂O₃
• 分子量: 196.206
• InChiKey: YDWVPBGFVFJJIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  61.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(2,6-Dimethoxypyrimidin-4-yl)propan-2-one 在 盐酸 、 水 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 48.0h， 以37.7 mg的产率得到Tetrahydro-1,2,3,4-dioxo-2,4-acetonyl-6-pyrimidin
  参考文献：
  名称：

  Short Access to 6-Substituted Pyrimidine Derivatives by the S_RN1 Mechanism. Synthesis of 6-Substituted Uracils through a One-Pot Procedure

  摘要：

  The synthesis of 6-substituted 2,4-dimethoxypyrimidines with different nucleophiles was accomplished with good to excellent yields (50-95%) through S(RN)1 reactions, starting from commercially available 6-chloro-2,4-dimethoxypyrimidine (1). Hydrolysis of these derivatives gave access to 6-substituted uracils with good yields and short times by the use of microwave irradiation. The preparation of uracils from 1 without the isolation of 2,4-dimethoxypyrimidine derivatives affords a rapid access to these compounds in good yields and excellent purity by avoiding an unnecessary step of purification.

  DOI：

  10.1021/jo101064e
• 作为产物：
  描述：

  6-氯-2,4-甲氧基嘧啶 、 丙酮 在 potassium tert-butylate 、 氨 作用下， 反应 0.5h， 生成 1-(2,6-Dimethoxypyrimidin-4-yl)propan-2-one
  参考文献：
  名称：

  Short Access to 6-Substituted Pyrimidine Derivatives by the S_RN1 Mechanism. Synthesis of 6-Substituted Uracils through a One-Pot Procedure

  摘要：

  The synthesis of 6-substituted 2,4-dimethoxypyrimidines with different nucleophiles was accomplished with good to excellent yields (50-95%) through S(RN)1 reactions, starting from commercially available 6-chloro-2,4-dimethoxypyrimidine (1). Hydrolysis of these derivatives gave access to 6-substituted uracils with good yields and short times by the use of microwave irradiation. The preparation of uracils from 1 without the isolation of 2,4-dimethoxypyrimidine derivatives affords a rapid access to these compounds in good yields and excellent purity by avoiding an unnecessary step of purification.

  DOI：

  10.1021/jo101064e

文献信息

• Short Access to 6-Substituted Pyrimidine Derivatives by the S_RN1 Mechanism. Synthesis of 6-Substituted Uracils through a One-Pot Procedure
  作者：Javier I. Bardagí、Roberto A. Rossi

  DOI：10.1021/jo101064e

  日期：2010.8.6

  The synthesis of 6-substituted 2,4-dimethoxypyrimidines with different nucleophiles was accomplished with good to excellent yields (50-95%) through S(RN)1 reactions, starting from commercially available 6-chloro-2,4-dimethoxypyrimidine (1). Hydrolysis of these derivatives gave access to 6-substituted uracils with good yields and short times by the use of microwave irradiation. The preparation of uracils from 1 without the isolation of 2,4-dimethoxypyrimidine derivatives affords a rapid access to these compounds in good yields and excellent purity by avoiding an unnecessary step of purification.