(Z)-1-(5-methyl-2-pyrazinyl)-2-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)prop-1-ene | 138336-02-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (Z)-1-(5-methyl-2-pyrazinyl)-2-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)prop-1-ene
• 英文别名: Pyrazine, 2-(2-(4-bromo-1-methyl-2-(methylthio)-1H-imidazol-5-yl)-1-propenyl)-5-methyl-, (Z)-；2-[(Z)-2-(5-bromo-3-methyl-2-methylsulfanylimidazol-4-yl)prop-1-enyl]-5-methylpyrazine
• CAS: 138336-02-4
• 化学式: C₁₃H₁₅BrN₄S
• 分子量: 339.259
• InChiKey: PMKJPSLKXZLUAK-YVMONPNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  68.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (Z)-1-(5-methyl-2-pyrazinyl)-2-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)prop-1-ene 在 potassium tert-butylate 作用下， 以 叔丁醇 、 苯 为溶剂， 反应 0.12h， 以28.2%的产率得到2-(methylthio)-3,4,8-trimethylimidazo<4,5-f>quinoxaline
  参考文献：
  名称：

  Regiospecific synthesis of the aminoimidazoquinoxaline (IQx) mutagens from cooked foods

  摘要：

  A versatile regiospecific synthesis has been developed to prepare the six dimethyl- and trimethyl-substituted 2-aminoimidazoquinoxaline (IQx) regioisomers 35, 36, 37, 38, 39, and 40 for complete and unambiguous characterization. The key reaction step in the synthetic sequence for these angular tricycles is a photodehydrohalogenative cyclization of suitably substituted pyrazinylimidazolylethylene intermediates derived from common pyrazine and fully functionalized imidazole precursors. The reaction sequence developed allows for versatility in the substitution pattern as well as total regioisomeric control for the synthesis of all possible methyl and polymethyl analogues of IQx. Comparison of the physical properties among the isomeric di- and trimethyl-IQx's has established the value of unambiguous regiospecific synthesis for structural assignments in this food mutagen series.

  DOI：

  10.1021/jo00031a017
• 作为产物：
  描述：

  Methyl 4-bromo-1-methyl-2-methylthio-5-imidazolecarboxylate 在 对甲苯磺酸 、 三氟乙酸 、 lithium diisopropyl amide 作用下， 以 甲苯 为溶剂， 反应 24.17h， 生成 (Z)-1-(5-methyl-2-pyrazinyl)-2-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)prop-1-ene
  参考文献：
  名称：

  Regiospecific synthesis of the aminoimidazoquinoxaline (IQx) mutagens from cooked foods

  摘要：

  A versatile regiospecific synthesis has been developed to prepare the six dimethyl- and trimethyl-substituted 2-aminoimidazoquinoxaline (IQx) regioisomers 35, 36, 37, 38, 39, and 40 for complete and unambiguous characterization. The key reaction step in the synthetic sequence for these angular tricycles is a photodehydrohalogenative cyclization of suitably substituted pyrazinylimidazolylethylene intermediates derived from common pyrazine and fully functionalized imidazole precursors. The reaction sequence developed allows for versatility in the substitution pattern as well as total regioisomeric control for the synthesis of all possible methyl and polymethyl analogues of IQx. Comparison of the physical properties among the isomeric di- and trimethyl-IQx's has established the value of unambiguous regiospecific synthesis for structural assignments in this food mutagen series.

  DOI：

  10.1021/jo00031a017

文献信息

• Regiospecific synthesis of the aminoimidazoquinoxaline (IQx) mutagens from cooked foods
  作者：Donald E. Bierer、John F. O'Connell、Jon R. Parquette、Charles M. Thompson、Henry Rapoport

  DOI：10.1021/jo00031a017

  日期：1992.2

  A versatile regiospecific synthesis has been developed to prepare the six dimethyl- and trimethyl-substituted 2-aminoimidazoquinoxaline (IQx) regioisomers 35, 36, 37, 38, 39, and 40 for complete and unambiguous characterization. The key reaction step in the synthetic sequence for these angular tricycles is a photodehydrohalogenative cyclization of suitably substituted pyrazinylimidazolylethylene intermediates derived from common pyrazine and fully functionalized imidazole precursors. The reaction sequence developed allows for versatility in the substitution pattern as well as total regioisomeric control for the synthesis of all possible methyl and polymethyl analogues of IQx. Comparison of the physical properties among the isomeric di- and trimethyl-IQx's has established the value of unambiguous regiospecific synthesis for structural assignments in this food mutagen series.