5-(hydroxymethyl)selenophene-2-carbaldehyde | 1162190-48-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(hydroxymethyl)selenophene-2-carbaldehyde
• 英文别名: 5-(Hydroxymethyl)selenophene-2-carbaldehyde
• CAS: 1162190-48-8
• 化学式: C₆H₆O₂Se
• 分子量: 189.072
• InChiKey: AFCOLZHMTFBWPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.05
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-(hydroxymethyl)selenophene-2-carbaldehyde 在 sodium hydroxide 、 silver nitrate 作用下， 以80%的产率得到5-Hydroxymethyl-selenophen-2-carbonsaeure
  参考文献：
  名称：

  Selenosartans: Novel selenophene analogues of milfasartan and eprosartan

  摘要：

  A series of selenophene analogues of the thiophene-containing anti hypertensives milfasartan and eprosartan were prepared and tested for AT(1) receptor antagonist properties. All four selenophene compounds proved to be potent AT(1) receptor antagonists, with pK(B) estimates indicating that these selenides are at least as effective as the thiophene parent compounds at blocking AT(1) receptor mediated responses. These results reveal that replacement of sulfur with selenium in thiophene-containing sartans does not interfere with sartan activity. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.136
• 作为产物：
  描述：

  5-(dimethoxymethyl)selenophene-2-carbaldehyde 在 4-甲基苯磺酸吡啶 sodium tetrahydroborate 作用下， 以 甲醇 、 丙酮 为溶剂， 反应 19.0h， 以60%的产率得到5-(hydroxymethyl)selenophene-2-carbaldehyde
  参考文献：
  名称：

  [EN] PROTEIN KINASE INHIBITORS
  [FR] INHIBITEURS DES PROTÉINES KINASES

  摘要：

  这项发明涉及到如下式(I)所示的硒吲哚化合物；式(I)中的每个变量在说明书中有定义。这些化合物可用于治疗癌症。

  公开号：

  WO2009085040A1

文献信息

• [EN] PROTEIN KINASE INHIBITORS<br/>[FR] INHIBITEURS DES PROTÉINES KINASES
  申请人：DCB USA LLC

  公开号：WO2009085040A1

  公开（公告）日：2009-07-09

  This invention relates to selenophene compounds of formula (I) shown below; each variable in formula (I) is defined in the specification. These compounds can be used to treat cancer.

  这项发明涉及到如下式(I)所示的硒吲哚化合物；式(I)中的每个变量在说明书中有定义。这些化合物可用于治疗癌症。
• Selenosartans: Novel selenophene analogues of milfasartan and eprosartan
  作者：Rebecca L. Grange、James Ziogas、Andrea J. North、James A. Angus、Carl H. Schiesser

  DOI：10.1016/j.bmcl.2007.11.136

  日期：2008.2

  A series of selenophene analogues of the thiophene-containing anti hypertensives milfasartan and eprosartan were prepared and tested for AT(1) receptor antagonist properties. All four selenophene compounds proved to be potent AT(1) receptor antagonists, with pK(B) estimates indicating that these selenides are at least as effective as the thiophene parent compounds at blocking AT(1) receptor mediated responses. These results reveal that replacement of sulfur with selenium in thiophene-containing sartans does not interfere with sartan activity. (C) 2007 Elsevier Ltd. All rights reserved.
• PROTEIN KINASE INHIBITORS
  申请人：Hong Pao-Chiung

  公开号：US20090163494A1

  公开（公告）日：2009-06-25

  This invention relates to selenophene compounds of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to treat cancer.

  这项发明涉及下面所示的化学式（I）的硒吡咯烷化合物：化学式（I）中的每个变量在说明书中有定义。这些化合物可用于治疗癌症。