MT-1303游离 | 942399-20-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: MT-1303游离
• 英文名称: Amiselimod
• 英文别名: 2-amino-2-[2-[4-heptoxy-3-(trifluoromethyl)phenyl]ethyl]propane-1,3-diol
• CAS: 942399-20-4
• 化学式: C₁₉H₃₀F₃NO₃
• 分子量: 377.4
• InChiKey: JVCPIJKPAKAIIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  75.7
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] DIARYL UREA DERIVATIVES AS P38 KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE DIARYLE-URÉE EN TANT QU'INHIBITEURS DE KINASE P38
  申请人：RESPIVERT LTD

  公开号：WO2016051187A1

  公开（公告）日：2016-04-07

  There are provided compounds of formula I, wherein R1A to R1E, R2 to R4, R5a, L and X1 to X3 have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

  提供了具有公式I的化合物，其中R1A至R1E，R2至R4，R5a，L和X1至X3的含义如描述中所示，这些化合物具有抗炎活性（例如，通过抑制p38丝裂原活化蛋白激酶酶家族中的一个或多个成员；Syk激酶；和酪氨酸激酶Src家族成员）并用于治疗，包括在药物组合中，特别是用于治疗包括肺部、眼睛和肠道炎症疾病在内的炎症性疾病。
• KINASE INHIBITORS
  申请人：Respivert Limited

  公开号：US20170291917A1

  公开（公告）日：2017-10-12

  There are provided compounds of formula I, wherein T, A, Q, Z, G, R 4 , R 5a , R 5b and n have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

  提供了化合物I的公式，其中T、A、Q、Z、G、R4、R5a、R5b和n的含义如描述中所示，这些化合物具有抗炎活性（例如，通过抑制p38丝裂原活化蛋白激酶酶家族中的一个或多个成员；Syk激酶；以及酪氨酸激酶Src家族的成员之一）并且在治疗中有用，包括在药物组合中，特别是用于治疗炎症性疾病，包括肺部、眼睛和肠道的炎症性疾病。
• [EN] 4-(4-(4-PHENYLUREIDO-NAPHTHALEN-1-YL)OXY-PYRIDIN-2-YL)AMINO-BENZOIC ACID DERIVATIVE AS P38 KINASE INHIBITOR<br/>[FR] DÉRIVÉ D'ACIDE 4-(4-(4-PHÉNYLURÉIDO-NAPHTALÉN -1-YL) OXY-PYRIDIN-2-YL) AMINO-BENZOÏQUE UTILISÉ EN TANT QU'INHIBITEUR DE LA KINASE P38
  申请人：RESPIVERT LTD

  公开号：WO2016051188A1

  公开（公告）日：2016-04-07

  There is provided a compound of formula I, which compound has antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and has use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

  提供了一种具有抗炎活性的化合物，该化合物通过抑制p38丝裂原活化蛋白激酶酶家族的一个或多个成员、Syk激酶以及酪氨酸激酶Src家族的成员之一来发挥作用，并且在治疗中具有用途，包括在药物组合中，特别是用于治疗包括肺部、眼睛和肠道炎症疾病在内的炎症性疾病。
• [EN] N-PHENYL-3-QUINAZOLIN-6-YL-BENZAMIDE DERIVATIVES AS P38 KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE N-PHÉNYL-3-QUINAZOLIN-6-YL-BENZAMIDE EN TANT QU'INHIBITEURS DE KINASE P38
  申请人：RESPIVERT LTD

  公开号：WO2016051186A1

  公开（公告）日：2016-04-07

  There are provided compounds of formula I, wherein R1A to R1E, R2, R3, R4A to R4C, L and X have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

  提供了公式I的化合物，其中R1A至R1E，R2，R3，R4A至R4C，L和X的含义如描述中所给，这些化合物具有抗炎活性（例如通过抑制p38丝裂原活化蛋白激酶酶家族的一个或多个成员，Syk激酶以及酪氨酸激酶Src家族的成员之一），并且可用于治疗，包括在药物组合中，特别是用于治疗炎症性疾病，包括肺部，眼睛和肠道的炎症性疾病。
• 4-ALKOXY-3-(TRIFLUOROMETHYL)BENZYL ALCOHOL PRODUCTION METHOD
  申请人：MITSUBISHI TANABE PHARMA CORPORATION

  公开号：US20190161432A1

  公开（公告）日：2019-05-30

  The present invention relates to a production method of 4-alkoxy-3-trifluoromethylbenzyl alcohol at a high conversion ratio, which can strictly suppress production of a byproduct by using DIBAL as a reducing agent.

  本发明涉及一种高转化率下制备4-烷氧基-3-三氟甲基苄醇的生产方法，该方法可以通过使用DIBAL作为还原剂严格抑制副产物的产生。