N,N,N',N'-四乙基甲二胺 | 102-53-4

• 物质功能分类: 有机原料 - 氨基化合物 - 无环单胺、多胺及其衍生物和盐
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N,N,N',N'-四乙基甲二胺
• 中文别名: N,N,N’,N’-四乙基甲二胺；N,N,N′,N′-四乙基甲二胺；N,N,N",N"-四乙基甲二胺
• 英文名称: bis(diethylamino)methane
• 英文别名: Methanediamine, N,N,N',N'-tetraethyl-；N,N,N',N'-tetraethylmethanediamine
• CAS: 102-53-4
• 化学式: C₉H₂₂N₂
• 分子量: 158.287
• InChiKey: UNEXJVCWJSHFNN-UHFFFAOYSA-N

物化性质

• 熔点：
  37.5°C (estimate)
• 沸点：
  166-169 °C(lit.)
• 密度：
  0.811 g/mL at 25 °C(lit.)
• 闪点：
  108 °F
• 溶解度：
  0.63 M
• 稳定性/保质期：

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• TSCA：
  Yes
• 危险等级：
  3
• 危险品标志：
  C
• 安全说明：
  S16,S26,S27,S36/37/39,S45
• 危险类别码：
  R34,R10
• WGK Germany：
  3
• 海关编码：
  2921290000
• 包装等级：
  III
• 危险标志：
  GHS02,GHS05
• 危险品运输编号：
  UN 2734 8/PG 2
• 危险性描述：
  H226,H314
• 危险性防范说明：
  P280,P305 + P351 + P338,P310
• 储存条件：
  室温

SDS

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Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
: N,N,N′,N′-Tetraethylmethanediamine
Product name
CAS-No. : 102-53-4

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Section 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Flammable liquids (Category 3)
Skin corrosion (Category 1B)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Flammable. Causes burns.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
Signal word Danger
Hazard statement(s)
Flammable liquid and vapour.
Causes severe skin burns and eye damage.
Precautionary statement(s)
Wear protective gloves/ protective clothing/ eye protection/ face
protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Immediately call a POISON CENTER or doctor/ physician.
Supplemental Hazard none
Statements
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
R-phrase(s)
R10 Flammable.
R34 Causes burns.
S-phrase(s)
S16 Keep away from sources of ignition - No smoking.
S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S27 Take off immediately all contaminated clothing.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S45 In case of accident or if you feel unwell, seek medical advice immediately
(show the label where possible).
Other hazards - none

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Formula : C9H22N2
Molecular Weight : 158,28 g/mol
Component Concentration
N,N,N',N'-Tetraethylmethylenediamine
CAS-No. 102-53-4 -
EC-No. 203-038-8

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Section 4. FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Consult a
physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
water. Consult a physician.
Most important symptoms and effects, both acute and delayed
Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and
skin., spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi,
pneumonitis, pulmonary edema, burning sensation, Cough, wheezing, laryngitis, Shortness of breath,
Headache, Nausea
Indication of any immediate medical attention and special treatment needed
no data available

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Section 5. FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large
fires, apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or
spray; solid streams of water may be ineffective. Cool all affected containers with flooding quantities of
water.
Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx)
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
Use water spray to cool unopened containers.

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation.
Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to
form explosive concentrations. Vapours can accumulate in low areas.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
place in container for disposal according to local regulations (see section 13).
Reference to other sections
For disposal see section 13.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Avoid inhalation of vapour or mist.
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
charge.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Specific end uses
no data available

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Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection
tested and approved under appropriate government standards such as NIOSH (US) or EN
166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type
of protective equipment must be selected according to the concentration and amount of the
dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
respirator. Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU).

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) Appearance Form: liquid
Colour: colourless
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing no data available
point
f) Initial boiling point and 166 - 169 °C - lit.
boiling range
g) Flash point 42 °C - closed cup
h) Evaporation rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density 0,811 g/cm3 at 25 °C
n) Water solubility no data available
o) Partition coefficient: n- no data available
octanol/water
p) Autoignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

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Section 10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
Heat, flames and sparks.
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available

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Section 11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation May be harmful if inhaled. Material is extremely destructive to the tissue of
the mucous membranes and upper respiratory tract.
Ingestion
May be harmful if swallowed. Causes burns.
Skin May be harmful if absorbed through skin. Causes skin burns.
Eyes
Causes eye burns.
Signs and Symptoms of Exposure
Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and
skin., spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi,
pneumonitis, pulmonary edema, burning sensation, Cough, wheezing, laryngitis, Shortness of breath,
Headache, Nausea
Additional Information
RTECS: Not available

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Section 12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
no data available

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Section 13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
company. Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging
Dispose of as unused product.

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Section 14. TRANSPORT INFORMATION
UN number
ADR/RID: 2734 IMDG: 2734 IATA: 2734
UN proper shipping name
ADR/RID: AMINES, LIQUID, CORROSIVE, FLAMMABLE, N.O.S. (N,N,N',N'-
Tetraethylmethylenediamine)
IMDG: AMINES, LIQUID, CORROSIVE, FLAMMABLE, N.O.S. (N,N,N',N'-
Tetraethylmethylenediamine)
IATA: Amines, liquid, corrosive, flammable, n.o.s. (N,N,N',N'-Tetraethylmethylenediamine)
Transport hazard class(es)
ADR/RID: 8 (3) IMDG: 8 (3) IATA: 8 (3)
Packaging group
ADR/RID: II IMDG: II IATA: II
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

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Section 15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  N,N,N',N'-四乙基甲二胺 在 乙酰氯 作用下， 以 乙腈 为溶剂， 生成 乙胺,N-(氯甲基)-N-乙基-
  参考文献：
  名称：

  Kachurin; Zaraiskii; Velichko, Russian Journal of Organic Chemistry, 1999, vol. 35, # 8, p. 1117 - 1120

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 作用下， 生成 N,N,N',N'-四乙基甲二胺
  参考文献：
  名称：

  Knoevenagel; Mercklin, Chemische Berichte, 1904, vol. 37, p. 4089

  摘要：

  DOI：
• 作为试剂：
  描述：

  3-(2,2,2-Trinitro-ethoxy)-propyne 在 N,N,N',N'-四乙基甲二胺 、 copper dichloride 作用下， 以20%的产率得到hexa-2,4-diyn-1,6-diol bis-trinitroethyl ether
  参考文献：
  名称：

  Trinitroethyl ethers of substituted alcohols

  摘要：

  The influence of the trinitromethane salt cations and the substituents in the alkyl moiety of chloromethyl ethers of alcohols on the yields of trinitroethyl ethers of the substituted alcohols formed from them was established. On this basis a representative series of previously unavailable trinitroethanol ethers was synthesized.

  DOI：

  10.1007/bf00961040

文献信息

• INTRACELLULAR DELIVERY VEHICLE
  申请人：KIRIN KABUSHIKI KAISHA

  公开号：US20190137503A1

  公开（公告）日：2019-05-09

  An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.

  一个表面覆盖正电荷的细胞内传递载体，一个所需成分或化合物装载在细胞内传递载体中的细胞内传递复合物，包括细胞内传递复合物的温度敏感探针，以及通过温度敏感探针测量细胞内温度的方法被揭示。由于其能够轻松将所需成分或化合物传递到细胞内而不抑制细胞增殖，这种细胞内传递载体非常有用。
• Synthesis, Characterization, and Anti-amoebic Screening of Core-Modified 5,20-Bis{2-{[(alkyl)(alkyl′)amino]methyl}ferrocen-1-yl}-10,15-diphenyl-21,23-dithiaporphyrin (=1,1″-(10,15-Diphenyl-21,23-dithiaporphine-5,20-diyl)bis[2-{[(alkyl)(alkyl′)amino]methyl}ferrocene]) Derivatives
  作者：Abdul R. Bhat、Asif I. Bhat、Fareeda Athar、Amir Azam

  DOI：10.1002/hlca.200800461

  日期：2009.8

  The synthesis of the first bis‐ferrocenyl‐substituted core‐modified porphyrins, 5,20‐bis2‐[(alkyl)(alkyl′)amino]methyl}ferrocen‐1‐yl}‐10,15‐diphenyl‐21,23‐dithiaporphyrin derivatives 6a–6j, via a multistep route is reported (Schemes 1, 2, and 4). The synthesis was carried out through acid‐catalyzed (BF3⋅Et2O) condensation of 1,1″‐[thiophene‐2,5‐diylbis(hydroxymethyl)]bis[2‐[(alkyl)(alkyl′)amino]methyl}ferrocenes]

  合成首个双二茂铁基取代的核心修饰卟啉，5,20-双2-[（（（烷基）（烷基'）氨基]甲基]甲基}二茂铁-1-基} -10,15-二苯基-21） ，23-dithiaporphyrin衍生物6A - 6J，通过一个多步途径被报告（方案1,2和4）。该合成通过酸催化（BF进行3 ⋅Et 2 O）的1,1“缩合- [噻吩-2,5-二基双（羟甲基）]双[2 - [（烷基）（烷基'）氨基]甲基}二茂铁] 4a – 4j和2,2'-[噻吩-2,5-二基双（苯基亚甲基）]双[1 H-吡咯]（5b）存在2,3-二氯-5,6-二氰基-1,4-苯醌（= 4,5-二氯-3,6-二氧代环己基1,4-二烯-1,2-二甲腈; DDQ）。通过各种光谱技术在每个步骤中对化合物进行表征。筛选了最终的化合物对组织溶大肠杆菌的HM1：IMSS菌株的体外抗厌氧活性（表2）。
• [EN] EPIANDROSTERONE AND/OR ANDROSTERONE DERIVATIVES AND METHOD OF USE THEREOF<br/>[FR] DÉRIVÉS D'ÉPIANDROSTÉRONE ET/OU D'ANDROSTÉRONE ET LEUR PROCÉDÉ D'UTILISATION
  申请人：SUTTER WEST BAY HOSPITALS DOING BUSINESS AS CALIFORNIA PACIFIC MEDICAL CT

  公开号：WO2012134446A1

  公开（公告）日：2012-10-04

  Disclosed herein are epiandrosterone and androsterone derivatives of Formula (II), process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.

  本文揭示了式（II）的雄烯酮和雄甾酮衍生物，其制备方法，药物组合物以及使用方法。
• Pharmacochemistry of Novel Aminoketone Phthalimide, Δ4-Tetrahydrophthalimide, and Arylsuccinimide Derivatives with Local Anaesthetic Activity
  作者：Eleni Sotiropoulou、Panos N. Kourounakis

  DOI：10.1002/ardp.19943270104

  日期：——

  prospective local anaesthetic activity were prepared. The structure of the synthesized compounds was confirmed by spectroscopic and elemental analyses. The physicochemical parameters (pka and logP) were also investigated. The local anaesthetic activity was determined in vitro on sciatic frog's nerve by the compound action potential technique: the phthalimide derivatives possess considerable local anaesthetic

  制备了许多具有预期局部麻醉活性的氨基酮。通过光谱和元素分析确认合成化合物的结构。还研究了理化参数(pka和logP)。采用复合动作电位技术体外测定坐骨蛙神经的局麻活性：邻苯二甲酰亚胺衍生物具有与利多卡因相当而高于普鲁卡因的相当大的局麻活性。
• Making Amines Strong Bases:  Thermodynamic Stabilization of Protonated Guests in a Highly-Charged Supramolecular Host¹
  作者：Michael D. Pluth、Robert G. Bergman、Kenneth N. Raymond

  DOI：10.1021/ja072654e

  日期：2007.9.1

  of the protonated amines are then used to calculate the effective basicity of the encapsulated amines. Depending on the nature of the guest, shifts in the effective basicities of the encapsulated amines of up to 4.5 pK(a) units are observed, signifying a substantial stabilization of the protonated form of the guest molecule and effectively making phosphines and amines strong bases.

  由金属-配体相互作用形成的高电荷、含空腔的超分子组装体作为宿主显着改变封装的质子化胺客体的有效碱度。封装的质子化胺和膦客体的范围显示出与受限结合环境一致的大小选择性。(31)P NMR 研究、质谱研究和客体封装的 pH 依赖性证实了封装客体的质子化。使用选择性反转恢复方法测量客体自交换率，发现与客体的大小相关，而不是与客体的碱度相关。来宾自交换的激活参数与已建立的来宾交换机制一致。然后使用质子化胺的结合常数来计算封装胺的有效碱度。根据客体的性质，观察到封装胺的有效碱度变化高达 4.5 pK(a) 单位，这表明客体分子的质子化形式基本稳定，并有效地使膦和胺成为强碱。

表征谱图