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7,8-Dihydro-6H-5,9-dioxa-dibenzo[a,c]cyclononene-1,13-diol

中文名称
——
中文别名
——
英文名称
7,8-Dihydro-6H-5,9-dioxa-dibenzo[a,c]cyclononene-1,13-diol
英文别名
(S)-7,8-Dihydro-6H-dibenzo[f,h][1,5]dioxonin-1,13-diol;8,12-dioxatricyclo[11.4.0.02,7]heptadeca-1(17),2,4,6,13,15-hexaene-3,17-diol
7,8-Dihydro-6H-5,9-dioxa-dibenzo[a,c]cyclononene-1,13-diol化学式
CAS
——
化学式
C15H14O4
mdl
——
分子量
258.274
InChiKey
VDVDETXSTRGZAW-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    2.9
  • 重原子数:
    19
  • 可旋转键数:
    0
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.2
  • 拓扑面积:
    58.9
  • 氢给体数:
    2
  • 氢受体数:
    4

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    phthalimidesulfenyl chloride7,8-Dihydro-6H-5,9-dioxa-dibenzo[a,c]cyclononene-1,13-diol氯仿 为溶剂, 反应 6.0h, 以64%的产率得到2-[12-(1,3-dioxiisoindolin-2-ylthio)-1,13-dihydroxy-6H,7H,8H-benzo[f]benzo[3,4-h]1,5-dioxonan-2-ylthio]isoindoline-1,3-dione
    参考文献:
    名称:
    6,6'-桥接的对映异构联苯中的扭转角控制了邻苯二甲酰亚胺亚磺酰氯的亲电取代
    摘要:
    邻苯二甲酰亚胺亚磺酰氯与2,2',6,6'-羟基联苯的反应允许制备3-和/或3,3'- N-硫代邻苯二甲酰亚胺衍生物,其可以容易地转化成相应的硫醇和/或二硫化物。根据联苯单元上的取代基和6,6'桥的长度,可以预测单或双取代以及亚磺酰基化的区域化学。
    DOI:
    10.1016/s0040-4020(03)00178-9
  • 作为产物:
    参考文献:
    名称:
    Asymmetric Synthesis of 6,6'-Dialkoxy-2,2'-biphenyldiols by Using Menthone as a Chiral Template
    摘要:
    Acetalization of prochiral 2,2',6,6'-biphenyltetrol with l-menthone proceeds in an enantiodifferentiating manner to give isomenthonide 5a of S-axial chirality as a major product, which can be used as a general intermediate for asymmetric synthesis of a series of (S)-6,6'-dialkoxy-2,2'-biphenyldiols 9a-f.
    DOI:
    10.1021/jo00104a005
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文献信息

  • General method for asymmetric synthesis of substituted 2,2′-biaryldiols via asymmetric desymmetrization of 2,2′,6,6′-tetrahydroxybiphenyl with l-menthone
    作者:Toshiro Harada、Shinji Ueda、Tran Mai Thi Tuyet、Atsushi Inoue、Katsuhiro Fujita、Masahiro Takeuchi、Nobuhiro Ogawa、Akira Oku、Motoo Shiro
    DOI:10.1016/s0040-4020(97)10094-1
    日期:1997.12
    Asymmetric desymmetrization of prochiral 2,2′,6,6′-biphenyltetrol by acetalization with l-menthone affords isomenthonide 5b of S-axial chirality. A variety of (S)-6,6′-dialkoxy-2,2′-biphenyldiols of high enantiomeric purities are synthesized by using 5b as an intermediate. Thus, etherification of the hydroxy groups of 5b followed by hydrolysis of the isomenthonide moiety give the corresponding 6,6′-dialkoxy-2
    通过用1-薄荷酮进行缩醛化来对前手性2,2',6,6'-联苯四醇进行不对称脱对称,得到异丁烯酸酯5b的S-轴手性。通过使用5b作为中间体,合成了多种高对映体纯度的(S)-6,6'-二烷氧基-2,2'-联苯二醇。因此,将5b的羟基醚化,然后将异薄荷酸酯部分水解,得到相应的6,6'-二烷氧基-2,2'-联苯二醇(12)。5b与1,ω-二溴代烷烃的分子间环化,然后水解产生2,2'-联苯二醇13在6和6'位置带有亚烷基二氧基桥。的区域选择性官能化13导致3,3'-二甲基,二苯基,和二(TBS)衍生物经由氨基甲酸酯衍生物的锂化定向或通过区域选择性溴化反应要么取得13。还讨论了缩醛化反应中立体选择性的起源以及2,2'-联苯二醇的轴向手性的热稳定性。
  • Tetraoxybiphenyl Ester Chiral Dopants for Cholesteric Liquid Crystal Displays
    申请人:Diehl Donald R.
    公开号:US20120273725A1
    公开(公告)日:2012-11-01
    A liquid crystal composition comprising a chiral dopant compound represented by the following formula: wherein: R1, R2 are independently aryl, alkyl, alkenyl, cycloalkyl, alkoxyaryl, alkaryl or heterocyclic all either substituted or unsubstituted, or combine to form a carbocyclic or heterocyclic ring; R3 and R4 are independently hydrogen, halogen, cyano, alkoxy, NHCOR7, NHSO2R7, COOR7, OCOR7, aryl, alkyl, alkenyl, cycloalkyl, alkoxyaryl, alkaryl or heterocyclic all either substituted or unsubstituted, or combine with either R1 or R2 to form a carbocylic or heterocyclic ring; R5 and R6 are independently hydrogen, CH2, CH, alkyl or aryl either substituted or unsubstituted, COOR7, or combine with L to form a carbocyclic or heterocyclic ring; R7 is aryl, alkyl, alkenyl, cycloalkyl, alkoxyaryl or heterocyclic all either substituted or unsubstituted; L is the non-metallic elements required to form a carbocyclic or heterocyclic ring, or a single bond or a double bond; m is 1-3; n is 0-12.
    一种液晶组合物,包括由以下式表示的手性掺杂剂化合物: 其中:R1,R2独立地为芳基,烷基,烯基,环烷基,烷氧基芳基,烷基芳基或杂环基,均为取代或未取代,或结合形成碳环或杂环;R3和R4独立地为氢,卤素,氰基,烷氧基,NHCOR7,NHSO2R7,COOR7,OCOR7,芳基,烷基,烯基,环烷基,烷氧基芳基,烷基芳基或杂环基,均为取代或未取代,或与R1或R2之一结合形成碳环或杂环;R5和R6独立地为氢,CH2,CH,烷基或芳基,均为取代或未取代,COOR7,或与L结合形成碳环或杂环;R7为芳基,烷基,烯基,环烷基,烷氧基芳基或杂环基,均为取代或未取代;L为形成碳环或杂环所需的非金属元素,或单键或双键;m为1-3;n为0-12。
  • Torsional angles in 6,6′-bridged atropoisomeric biphenyls control the electrophilic substitution with phthalimidesulfenyl chloride
    作者:Giovanna Delogu、Davide Fabbri、Stefano Menichetti、Cristina Nativi
    DOI:10.1016/s0040-4020(03)00178-9
    日期:2003.3
    The reaction of phthalimidesulfenyl chloride with 2,2′,6,6′-hydroxylated biphenyls allowed the preparation of 3- and/or 3,3′-N-thiophthalimide derivatives which can be easily transformed into the corresponding thiols and/or disulfides. Mono- or bis-substitution, as well as the regiochemistry of the sulfenylation, are predictable as a function of the substituents on the biphenyl unit and the length
    邻苯二甲酰亚胺亚磺酰氯与2,2',6,6'-羟基联苯的反应允许制备3-和/或3,3'- N-硫代邻苯二甲酰亚胺衍生物,其可以容易地转化成相应的硫醇和/或二硫化物。根据联苯单元上的取代基和6,6'桥的长度,可以预测单或双取代以及亚磺酰基化的区域化学。
  • Harada Toshiro, Ueda Shinji, Yoshida Tetsuya, Inoue Atsushi, Takeuchi Mas+, J. Org. Chem, 59 (1994) N 25, S 7575-7576
    作者:Harada Toshiro, Ueda Shinji, Yoshida Tetsuya, Inoue Atsushi, Takeuchi Mas+
    DOI:——
    日期:——
  • [EN] TETRAOXYBIPHENYL ESTER CHIRAL DOPANTS FOR CHOLESTERIC LIQUID CRYSTAL DISPLAYS<br/>[FR] DOPANTS CHIRAUX ESTERS TÉTRAOXYBIPHÉNYLÉS POUR DES DISPOSITFS D'AFFICHAGE À CRISTAUX LIQUIDES CHOLESTÉRIQUES
    申请人:KENT DISPLAYS INC
    公开号:WO2012149124A2
    公开(公告)日:2012-11-01
    A liquid crystal composition comprising a chiral dopant compound represented by the following formula: wherein: Rl, R2 are independently aryl, alkyl, alkenyl, cycloalkyl, alkoxyaryl, alkaryl or heterocyclic all either substituted or unsubstituted, or combine to form a carbocyclic or heterocyclic ring; R3 and R4 are independently hydrogen, halogen, cyano, alkoxy, NHCOR7, NHS02R7, COOR7, OCOR7, aryl, alkyl, alkenyl, cycloalkyl, alkoxyaryl, alkaryl or heterocyclic all either substituted or unsubstituted, or combine with either Rl or R2 to form a carbocylic or heterocyclic ring; R5 and R6 are independently hydrogen, CH2, CH, alkyl or aryl either substituted or unsubstituted, COOR7, or combine with L to form a carbocyclic or heterocyclic ring; R7 is aryl, alkyl, alkenyl, cycloalkyl, alkoxyaryl or heterocyclic all either substituted or unsubstituted; L is the non-metallic elements required to form a carbocyclic or heterocyclic ring, or a single bond or a double bond; m is 1-3; n is 0-12.
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