6-chloro-6-deoxy-D-glucitol | 76986-26-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-chloro-6-deoxy-D-glucitol
• 英文别名: (2S,3R,4S,5S)-6-chlorohexane-1,2,3,4,5-pentol
• CAS: 76986-26-0
• 化学式: C₆H₁₃ClO₅
• 分子量: 200.619
• InChiKey: MRGPKZIDNGFPIU-JGWLITMVSA-N

物化性质

• 沸点：
  529.2±50.0 °C(Predicted)
• 密度：
  1.567±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  101
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6-脱氧-6-氯-D-吡喃葡萄糖 在 conc. sulphuric acid 、 sodium borohydrid 、 乙酸酐 作用下， 以 水 为溶剂， 生成 6-chloro-6-deoxy-D-glucitol
  参考文献：
  名称：

  6-Chloro-6-deoxy-D-hexitols, compositions containing them and their use

  摘要：

  6-氯-6-去氧-D-己糖醇是一类新型化合物，它们的酯具有男性抗生育活性，因此可用于抗生育组合物中。它们是通过6-氯-6-去氧-D-己糖的还原制备的。

  公开号：

  US04442123A1

文献信息

• 6-Chloro-6-deoxy-D-hexitols, their esters, their preparation, fertility control compositions containing them and their use in a contraceptive method
  申请人：TATE & LYLE PUBLIC LIMITED COMPANY

  公开号：EP0015652A1

  公开（公告）日：1980-09-17

  6-Chloro-6-deoxy-D-hexitols, a novel class of compounds, and their esters, possess male antifertility activity and are thus useful in antifertility compositions. They are prepared by reduction of 6-chloro-6-deoxy-D-hexoses.

  6-氯-6-脱氧-D-己糖醇是一类新型化合物，其酯类具有抗男性不育活性，因此可用于抗不育组合物中。它们是通过还原 6-氯-6-脱氧-D-己糖制备的。
• METHOD FOR OPTIMIZING POST-TRANSLATIONAL MODIFICATIONS ON RECOMBINANT PROTEINS
  申请人：Leszcyniecka, Magdalena

  公开号：EP3094639A1

  公开（公告）日：2016-11-23
• Method for Optimizing Post-Translational Modifications on Recombinant Proteins
  申请人：LESZCYNIECKA Magdalena

  公开号：US20160340706A1

  公开（公告）日：2016-11-24

  A method for optimizing post-translational modifications of recombinant proteins expressed in living cells is described. More particularly, a method for modulation of host proteins in living cells that control PTMs on recombinant proteins is described that has particularly useful applications in developing manufacturing process changes or in biosimilar development. The goal of this modulation is to produce a recipe for production of a recombinant protein in the new process or in the biosimilar that will produce a targeted PTM profile in the resulting protein product. In the method one or more modulators are selected, as from a modulator library, which affect the activity of host proteins. These modulators are added to media during production such that the resulting product matches the PTMs of the reference product. The ideal set of modulators and their concentrations are identified through a unique iterative process and the combined modulators and their concentrations constitute a recipe for growth media for the production of said recombinant protein. The methodology to obtain such a recipe described herein may then be used in many applications, such as optimizing new batches of recombinant protein drugs, developing biosimilar or bio-better drugs.
• A METHOD FOR DEVELOPMENT OF RECOMBINANT PROTEINS WITH FINGERPRINT LIKE SIMILARITY TO THE REFERENCE PRODUCT
  申请人：STC Biologics, Inc.

  公开号：US20180180626A1

  公开（公告）日：2018-06-28

  The present invention relates to the methods of developing recombinant proteins with a fingerprint like similarity to the reference product or the originator. The method is particularly useful in the development of biosimilar products. This method can also be used to establish comparability during the manufacturing process change for the originator products. Hie methods described herein are used to obtain a recipe for the production of a biosimilar product or a recombinant protein using a process that may be different from the original but that yields a recombinant protein that has fingerprint level of similarity to the reference product. The methods described herein can also used to obtain a fingerprinting analysis package for a biosimilar that can be submitted to regulatory agency for abbreviated biosimilar approval. While currently available analytical methods can identify and quantitate specific modifications on a recombinant, protein, no methods currently exist to measure and determine the concentration of product variants in a complex: mixture. The analytical methods described herein provide for identification and quantitation of the modifications of the recombinant proteins and of product variants in a complex mixture by utilizing various in silico computational approaches to transform analytical data and derive product variant distribution.
• US4442123A
  申请人：——

  公开号：US4442123A

  公开（公告）日：1984-04-10