7-[(2-hydroxy-phenyl)-(4-methyl-pyridin-2-ylamino)-methyl]-quinolin-8-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-[(2-hydroxy-phenyl)-(4-methyl-pyridin-2-ylamino)-methyl]-quinolin-8-ol
• 英文别名: 7-[(2-Hydroxyphenyl)-[(4-methylpyridin-2-yl)amino]methyl]quinolin-8-ol
• 化学式: C₂₂H₁₉N₃O₂
• 分子量: 357.412
• InChiKey: PGSFOENHEGHOSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  78.3
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氨基-4-甲基吡啶 、 8-羟基喹啉 、 水杨醛 以 甲醇 为溶剂， 生成 7-[(2-hydroxy-phenyl)-(4-methyl-pyridin-2-ylamino)-methyl]-quinolin-8-ol
  参考文献：
  名称：

  Designing, synthesis and evaluation of derived analogues of selected small molecule non-peptidic inhibitors against serotype BoNT/ F

  摘要：

  DOI：

  10.1016/j.toxicon.2022.106981

文献信息

• FLAVIVIRUS INHIBITORS AND METHODS FOR THEIR USE
  申请人：Padmanabhan Radhakrishnan

  公开号：US20110224207A1

  公开（公告）日：2011-09-15

  Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor, e.g., a Flavivirus serine protease inhibitor. These methods are useful in treating, preventing, and/or ameliorating Flavivurs infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus.
• Flavivirus Inhibitors and Methods of Their Use
  申请人：Padmanabhan Radhakrishnan

  公开号：US20140038962A1

  公开（公告）日：2014-02-06

  Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor, e.g., a Flavivirus serine protease inhibitor. These methods are useful in treating, preventing, and/or ameliorating Flavivirus infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus.
• US8563580B2
  申请人：——

  公开号：US8563580B2

  公开（公告）日：2013-10-22
• US8906937B2
  申请人：——

  公开号：US8906937B2

  公开（公告）日：2014-12-09
• [FR] INHIBITEUR DE FLAVIVIRUS ET PROCÉDÉS D'UTILISATION DE CEUX-CI
  申请人：UNIV GEORGETOWN

  公开号：WO2010039538A2

  公开（公告）日：2010-04-08

  Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor, e.g., a Flavivirus serine protease inhibitor. These methods are useful in treating, preventing, and/or ameliorating Flavivirus infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus.