7-chloro-9-(2-chlorophenyl)-3-(trifluoromethyl)-3,4-dihydroacridin-1(2H)-one | 1052719-52-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-chloro-9-(2-chlorophenyl)-3-(trifluoromethyl)-3,4-dihydroacridin-1(2H)-one
• 英文别名: 7-chloro-9-(2-chlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-acridin-1-one
• CAS: 1052719-52-4
• 化学式: C₂₀H₁₂Cl₂F₃NO
• 分子量: 410.223
• InChiKey: AXVHEOGCZRJWMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  27
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-(三氟甲基)环己烷-1,3-二酮 、 2-氨基-2',5-二氯二苯酮 在 盐酸 作用下， 以 水 为溶剂， 反应 0.5h， 以93%的产率得到7-chloro-9-(2-chlorophenyl)-3-(trifluoromethyl)-3,4-dihydroacridin-1(2H)-one
  参考文献：
  名称：

  Novel fluorinated acridone derivatives. Part 1: Synthesis and evaluation as potential anticancer agents

  摘要：

  We report on the synthesis of a novel series of fluorinated acridones from 5-trifluoromethyl-1,3-cyclohexanedione. The cytotoxic activities of the compounds were studied in several cancer cells. Compounds 9a, 9c, 9e, 9f, and 9h exhibited significant anticancer activities in selected cell lines. Compound 9c is the most active showing GI(50) that ranged in values from 0.13 to 26 mu M, covering a wide range of cancer cell lines. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.05.078

文献信息

• Novel fluorinated acridone derivatives. Part 1: Synthesis and evaluation as potential anticancer agents
  作者：Olugbeminiyi O. Fadeyi、Saudat T. Adamson、E. Lewis Myles、Cosmas O. Okoro

  DOI：10.1016/j.bmcl.2008.05.078

  日期：2008.7

  We report on the synthesis of a novel series of fluorinated acridones from 5-trifluoromethyl-1,3-cyclohexanedione. The cytotoxic activities of the compounds were studied in several cancer cells. Compounds 9a, 9c, 9e, 9f, and 9h exhibited significant anticancer activities in selected cell lines. Compound 9c is the most active showing GI(50) that ranged in values from 0.13 to 26 mu M, covering a wide range of cancer cell lines. (C) 2008 Elsevier Ltd. All rights reserved.