(+/-)-Benzyl-<4-(7-chlor-<4>chinolyl)-pentyl>-methylamin | 31510-56-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (+/-)-Benzyl-<4-(7-chlor-<4>chinolyl)-pentyl>-methylamin
• 英文别名: n1-Benzyl-n4-(7-chloroquinolin-4-yl)-n1-methylpentane-1,4-diamine；1-N-benzyl-4-N-(7-chloroquinolin-4-yl)-1-N-methylpentane-1,4-diamine
• CAS: 31510-56-2
• 化学式: C₂₂H₂₆ClN₃
• 分子量: 367.922
• InChiKey: WWYGIZAIIQNKMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  28.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Methods of Facilitating Neural Cell Survival Using GDNF Family Ligand (GFL) Mimetics or RET Signaling Pathway Activators
  申请人：Saarma Mart

  公开号：US20130030180A1

  公开（公告）日：2013-01-31

  Disclosed are compounds and methods for treating neurological and other disorders by administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for GFRα receptor molecules, which can be mimetics of glial-derived neurotrophic factor (GDNF) family ligands (GFLs), GFRα/RET signaling pathway agonists, and/or direct RET agonists (activators).
• US8901129B2
  申请人：——

  公开号：US8901129B2

  公开（公告）日：2014-12-02
• [EN] METHODS OF FACILITATING NEURAL CELL SURVIVAL USING GDNF FAMILY LIGAND (GFL) MIMETICS OR RET SIGNALING PATHWAY ACTIVATORS<br/>[FR] PROCÉDÉS DESTINÉS À FACILITER LA SURVIE DE CELLULES NEURONALES EN UTILISANT DES MIMÉTIQUES DE LIGANDS DE LA FAMILLE DES GDNF (GFL) OU DES ACTIVATEURS DE LA VOIE DE SIGNALISATION DU RET
  申请人：BALTIC TECHNOLOGY DEV LTD

  公开号：WO2011070177A2

  公开（公告）日：2011-06-16

  Disclosed are compounds and methods for treating neurological and other disorders by administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for GFRα receptor molecules, which can be mimetics of glial-derived neurotrophic factor (GDNF) family ligands (GFLs), GFRα/RET signaling pathway agonists, and/or direct RET agonists (activators).