4-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-cyclopenta[c]benzo[f]quinoline | 331674-50-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-cyclopenta[c]benzo[f]quinoline
• 英文别名: 12-(4-fluorophenyl)-11-azatetracyclo[8.7.0.02,7.013,17]heptadeca-1(10),2,4,6,8,13(17)-hexaene
• CAS: 331674-50-1
• 化学式: C₂₂H₁₈FN
• 分子量: 315.39
• InChiKey: QHMIKESFROCKJC-UHFFFAOYSA-N

物化性质

• 熔点：
  161-162 °C(Solv: ethanol (64-17-5))
• 沸点：
  513.1±50.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-cyclopenta[c]benzo[f]quinoline 在 盐酸 作用下， 以 水 、 正丁醇 为溶剂， 反应 3.0h， 以74%的产率得到2,3-dihydro-4-(4-fluorophenyl)-1H-benzo[f]cyclopenta[c]quinoline
  参考文献：
  名称：

  Condensation of fluorine-substituted benzaldehydes with amines and cyclic ketones

  摘要：

  Condensation of fluorine-containing benzaldehydes with naphthalen-2-amine or quinolin-6-amine and cyclic ketones (cyclopentanone, cyclohexanone, and 4-methylcyclohexanone) gave new fluorine-containing derivatives of cyclopenta[c]benzo[f]quinoline, benzo[a]phenanthridine, and cyclopenta[a]- and benzo[a]-[4,7]phenanthroline. Intermediate products, 2-[(fluorophenyl)(2-naphthylamino or quinolin-6-ylamino)methylidene] cyclohexanones, dihydrobenzo[f]quinolines, and dihydro-4,7-phenanthrolines, were isolated.

  DOI：

  10.1134/s1070428008060080
• 作为产物：
  描述：

  2-p-Fluorobenzylideneaminonaphthalene 、 环戊酮 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 6.0h， 以68%的产率得到4-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-cyclopenta[c]benzo[f]quinoline
  参考文献：
  名称：

  Condensation of fluorine-substituted benzaldehydes with amines and cyclic ketones

  摘要：

  Condensation of fluorine-containing benzaldehydes with naphthalen-2-amine or quinolin-6-amine and cyclic ketones (cyclopentanone, cyclohexanone, and 4-methylcyclohexanone) gave new fluorine-containing derivatives of cyclopenta[c]benzo[f]quinoline, benzo[a]phenanthridine, and cyclopenta[a]- and benzo[a]-[4,7]phenanthroline. Intermediate products, 2-[(fluorophenyl)(2-naphthylamino or quinolin-6-ylamino)methylidene] cyclohexanones, dihydrobenzo[f]quinolines, and dihydro-4,7-phenanthrolines, were isolated.

  DOI：

  10.1134/s1070428008060080

文献信息

• Condensation of fluorine-substituted benzaldehydes with amines and cyclic ketones
  作者：N. G. Kozlov、K. N. Gusak

  DOI：10.1134/s1070428008060080

  日期：2008.6

  Condensation of fluorine-containing benzaldehydes with naphthalen-2-amine or quinolin-6-amine and cyclic ketones (cyclopentanone, cyclohexanone, and 4-methylcyclohexanone) gave new fluorine-containing derivatives of cyclopenta[c]benzo[f]quinoline, benzo[a]phenanthridine, and cyclopenta[a]- and benzo[a]-[4,7]phenanthroline. Intermediate products, 2-[(fluorophenyl)(2-naphthylamino or quinolin-6-ylamino)methylidene] cyclohexanones, dihydrobenzo[f]quinolines, and dihydro-4,7-phenanthrolines, were isolated.