(E)-2-(N-methyl-N-phenylcarbamoyl)-1-m-tolylvinyl pivalate | 1185649-84-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-2-(N-methyl-N-phenylcarbamoyl)-1-m-tolylvinyl pivalate
• 英文别名: [(E)-3-(N-methylanilino)-1-(3-methylphenyl)-3-oxoprop-1-enyl] 2,2-dimethylpropanoate
• CAS: 1185649-84-6
• 化学式: C₂₂H₂₅NO₃
• 分子量: 351.445
• InChiKey: ZULSHRXJWBCFHB-XDJHFCHBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-methyl-N-phenyl-3-(m-tolyl)propiolamide 、 苯 、 三甲基乙酸 在 silver(I) acetate 、 palladium diacetate 、 三苯基膦 作用下， 反应 24.0h， 以45%的产率得到1-methyl-3-phenyl-4-m-tolylquinolin-2(1H)-one
  参考文献：
  名称：

  Selective Synthesis of 3-Aryl Quinolin-2(1H)-ones and 3-(1-Arylmethylene)oxindoles Involving a 2-Fold Arene C−H Activation Process

  摘要：

  A novel and selective palladium-catalyzed C-H activation protocol has been developed for the synthesis of 3-aryl quinolin-2(1H)-ones and 3-(1-arylmethylene)oxindoles with use of PivOH as the switch. In the presence of Pd(OAc)(2), AgOAc, and PivOH, a variety or N-methyl anilides reacted with arenes to afford the corresponding 3-aryl quinolin-2(l H)-ones in moderate yields, whereas the selectivity was shifted toward 3-(1-arylmethylene)oxindoles in the absence of PivOH.

  DOI：

  10.1021/jo901314t

文献信息

• Selective Synthesis of 3-Aryl Quinolin-2(1<i>H</i>)-ones and 3-(1-Arylmethylene)oxindoles Involving a 2-Fold Arene C−H Activation Process
  作者：Dong-Jun Tang、Bo-Xiao Tang、Jin-Heng Li

  DOI：10.1021/jo901314t

  日期：2009.9.4

  A novel and selective palladium-catalyzed C-H activation protocol has been developed for the synthesis of 3-aryl quinolin-2(1H)-ones and 3-(1-arylmethylene)oxindoles with use of PivOH as the switch. In the presence of Pd(OAc)(2), AgOAc, and PivOH, a variety or N-methyl anilides reacted with arenes to afford the corresponding 3-aryl quinolin-2(l H)-ones in moderate yields, whereas the selectivity was shifted toward 3-(1-arylmethylene)oxindoles in the absence of PivOH.