trans,trans-2,2,8,8-Tetramethylnona-3,6-dien-5-one | 73838-78-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: trans,trans-2,2,8,8-Tetramethylnona-3,6-dien-5-one
• 英文别名: (3E,6E)-2,2,8,8-tetramethyl-3,6-nonadien-5-one；(3E,6E)-2,2,8,8-Tetramethylnona-3,6-dien-5-one
• CAS: 73838-78-5
• 化学式: C₁₃H₂₂O
• 分子量: 194.317
• InChiKey: GRAOFPNGYROXQS-FIFLTTCUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  一氧化碳 、 [(E)-3,3-二甲基-1-丁烯基]氯化汞 在 di(rhodium)tetracarbonyl dichloride lithium chloride 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以78%的产率得到trans,trans-2,2,8,8-Tetramethylnona-3,6-dien-5-one
  参考文献：
  名称：

  Mercury in organic chemistry. 18. Synthesis of symmetrical divinyl and diaryl ketones via rhodium-catalyzed carbonylation of vinyl- and arylmercurials

  摘要：

  DOI：

  10.1021/jo01307a022

文献信息

• COMPOUNDS USEFUL AGAINST KINETOPLASTIDEAE PARASITES
  申请人：Davioud-Charvet Elisabeth

  公开号：US20120214996A1

  公开（公告）日：2012-08-23

  Dibenzylidene and heterobenzylideneacetone derivatives, related 4-piperidones, related 4-thiopyranones and the corresponding sulfinyl- and sulfonyl-analogues for their use for prophylaxis or treatment of trypanosomiasis and leishmaniasis.

  二苄基亚烷和杂二苄基亚烷乙酮衍生物，相关的4-哌啶酮，相关的4-噻opyranones以及相应的亚磺酰基和磺酰基类似物，用于预防或治疗锥虫病和利什曼病。
• A new elongation reaction of three carbon units
  作者：Akio Murai、Atsushi Abiko、Naoki Shimada、Tadashi Masamune

  DOI：10.1016/s0040-4039(01)91267-5

  日期：1984.1

  A new modification of Peterson reaction leading to elongation of three carbon units by treatment of aldehydes with titanium ate complex, prepared from 1-lithio-1-(1-alkoxy)allyltrimethylsilane and titanium(IV) isopropoxide, is described.

  描述了一种新的彼得森反应改性方法，该方法通过用钛酸酯配合物处理醛来延长三个碳单元，该钛酸酯配合物是由1-硫代-1-（1-烷氧基）烯丙基三甲基硅烷和异丙醇钛（IV）制备的。
• Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states
  申请人：Bowen J. Phillip

  公开号：US20090018167A1

  公开（公告）日：2009-01-15

  The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, including angiogenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.

  本发明涉及用作血管生成抑制剂的查尔酮和查尔酮衍生物和类似物。这些廉价合成的化合物表现出意外的良好的血管生成抑制活性。本发明还涉及将查尔酮及其类似物用作抗肿瘤/抗癌剂，并用于治疗许多与血管生成有关的疾病或病态，包括血管生成性皮肤疾病，如银屑病、痤疮、酒渣鼻、疣、湿疹、血管瘤、淋巴管生成等，以及慢性炎症性疾病，如关节炎。
• ELECTRICAL INSULATING RESIN MATERIAL, ELECTRICAL INSULATING MATERIAL, AND ELECTRIC WIRE AND CABLE USING THE SAME
  申请人：Japan Polyolefins Co., Ltd.

  公开号：EP1146083A1

  公开（公告）日：2001-10-17

  The present invention relates to a resin material for an electrical insulating material, an electrical insulating material and electric wire and cable using the same. A resin material for an electrical insulating material according to present invention is characterized in that the resin component thereof comprises an ethylene α-olefin copolymer (A) which satisfies specific conditions, such as a density of 0.92 ~ 0.96 g/cm3, a melt flow rate (MFR) of 0.01 ~ 200 g/10 minutes, a molecular weight distribution (Mw/Mn) of 1.5 ~ 5.0, and possessing only one peak in terms of the number of peaks observed in an elution temperature-eluted amount curve as measured by the temperature raising elution fractionation (TREF) method, etc., wherein said resin component contains a unit derived from at least one type of monomer selected from among a carbonyl or carbonyl derivative group-containing monomer, a hydroxyl group-containing monomer, a nitro group-containing monomer, a nitrile group-containing monomer, an aromatic ring-containing monomer, and a compound or monomer containing two or more ethylenic linkages. This resin material for an electrical insulating material is suitable for use in an electrical insulating material for an electric wire and cable, as it exhibits excellent processability and electrical insulating properties without degradation of the mechanical strength, and even after cross-linking, exhibits superior electrical insulating properties.

  本发明涉及一种用于电气绝缘材料的树脂材料、一种电气绝缘材料和使用该材料的电线电缆。根据本发明的一种电气绝缘材料用树脂材料，其特征在于其树脂组分包括乙烯 α-烯烃共聚物（A），该共聚物满足特定条件，例如密度为 0.92 ~ 0.96 克/立方厘米，熔体流动速率（MFR）为 0.01 ~ 200 克/10 分钟，分子量分布（Mw/Mn）为 1.5 ~ 5.0，通过升温洗脱分馏（TREF）法测定洗脱温度-洗脱量曲线中观察到的峰数只有一个峰等、其中，所述树脂组分含有至少一种单体衍生的单元，这些单体选自含羰基或羰基衍生物基团的单体、含羟基的单体、含硝基的单体、含腈基的单体、含芳香环的单体以及含两个或两个以上乙烯基连接的化合物或单体。这种用于电气绝缘材料的树脂材料适用于电线电缆的电气绝缘材料，因为它具有优异的加工性能和电气绝缘性能，且不会降低机械强度，甚至在交联后仍具有优异的电气绝缘性能。
• USE OF A RESIN MATERIAL FOR ELECTRICAL INSULATING AND ELECTRIC WIRE AND CABLE USING THE SAME
  申请人：Japan Polyolefins Co., Ltd.

  公开号：EP1146083B1

  公开（公告）日：2005-01-05