N-(2,2-二甲氧基乙基)甲基丙烯酰胺 | 95984-11-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-(2,2-二甲氧基乙基)甲基丙烯酰胺
• 中文别名: N-(2,2-二甲氧基)-2-甲基-2-丙酰胺；N-(2,2-二甲氧基)-2-甲基丙烯酰胺
• 英文名称: methacrylamidoacetaldehyde dimethyl acetal
• 英文别名: N-(2,2-dimethoxyethyl)methacrylamide；methacrylamidoacetaldehyde dimethylacetal；N-(2,2-dimethoxyethyl)-2-methylprop-2-enamide
• CAS: 95984-11-5
• 化学式: C₈H₁₅NO₃
• 分子量: 173.212
• InChiKey: MGARLISKINLYPI-UHFFFAOYSA-N

物化性质

• 沸点：
  304.0±42.0 °C(Predicted)
• 密度：
  0.922

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2924199090

反应信息

• 作为产物：
  描述：

  甲基丙烯酸N-羟琥珀酸亚胺酯 、 氨基乙醛缩二甲醇 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 72.0h， 以90%的产率得到N-(2,2-二甲氧基乙基)甲基丙烯酰胺
  参考文献：
  名称：

  PARAMAGNETIC SUPPORTS FOR USE AS ASSAY REAGENTS

  摘要：

  一种用作测定试剂的组合物包括具有合成共聚物涂层的顺磁性固体支持。合成共聚物包括两种或三种第一共聚单体，第二共聚单体和第三共聚单体，并进一步包括聚乙烯骨架。

  公开号：

  US20160340541A1
• 作为试剂：
  描述：

  氨基乙醛缩二甲醇 、 2,2,6,6-四甲基哌啶氧化物 、 甲基丙烯酰氯 在 N-(2,2-二甲氧基乙基)甲基丙烯酰胺 、 氮气 、 petroleum ether 、 氯化钠 、 甲基叔丁基醚 、 magnesium sulfate 作用下， 以 sodium hydroxide 为溶剂， 反应 26.0h， 生成 N-(2,2-二甲氧基乙基)甲基丙烯酰胺
  参考文献：
  名称：

  POLY(OLIGOETHYLENE GLYCOL METHACRYLATE) HYDROGEL COMPOSITIONS, AND METHODS OF USE THEREOF

  摘要：

  本申请涉及水凝胶组合物，包括第一和第二前体聚合物，其中前体聚合物是经过修饰的聚（寡乙二醇甲基丙烯酸酯）共聚物，通过亲电-亲核反应交联。

  公开号：

  US20160151535A1

文献信息

• Injectable and tunable poly(ethylene glycol) analogue hydrogels based on poly(oligoethylene glycol methacrylate)
  作者：Niels M. B. Smeets、Emilia Bakaic、Mathew Patenaude、Todd Hoare

  DOI：10.1039/c3cc48514e

  日期：——

  Injectable PEG-analogue hydrogels based on poly(oligoethylene glycol methacrylate) have been developed based on complementary hydrazide and aldehyde reactive linear polymer precursors. These hydrogels display the desired biological properties of PEG, form covalent networks in situ following injection, and are easily modulated for improved control over their functionality and physiochemical properties.

  基于聚（甲基丙烯酸低聚乙二醇酯）的可注射 PEG 类似物水凝胶是在互补酰肼和醛反应线性聚合物前体的基础上开发出来的。这些水凝胶具有 PEG 所需的生物特性，注射后可在原位形成共价网络，并且易于调节，从而改善对其功能和理化特性的控制。
• Process for the manufacture of moldings
  申请人：——

  公开号：US20030025222A1

  公开（公告）日：2003-02-06

  The invention relates to a process for the manufacture of a molding comprising the steps of a) preparing an aqueous solution comprising a water-soluble prepolymer having crosslinkable groups and a further polymer which is devoid of crosslinkable groups, b) introducing the solution obtained into a mold, c) triggering the crosslinking, and d) opening the mold such that the molding can be removed from the mold. According to the process of the invention moldings such as contact lenses may be manufactured with an improved quality and an improved overall yield.

  本发明涉及一种制造成型品的工艺，包括以下步骤：a）制备含有可交联基团的水溶性预聚物和不含交联基团的进一步聚合物的水溶液；b）将所得溶液注入模具中；c）触发交联；以及d）打开模具，以便将成型品从模具中取出。根据本发明的工艺，例如可以制造出质量更好、综合收率更高的接触镜等成型品。
• Photocrosslinked polymers
  申请人：Ciba-Geigy Corporation

  公开号：US05508317A1

  公开（公告）日：1996-04-16

  The invention relates to a novel process for the manufacture of mouldings, especially contact lenses, in which a soluble prepolymer comprising crosslinkable groups is crosslinked in solution, and also to mouldings, especially contact lenses, obtainable in accordance with that process. The present invention relates also to novel prepolymers that can be used in the process according to the invention, especially derivatives of a polyvinyl alcohol having a molecular weight of at least about 2000 that, based on the number of hydroxy groups of the polyvinyl alcohol, comprise from approximately 0.5 to approximately 80% of units of formula I ##STR1## wherein R is lower alkylene having up to 8 carbon atoms, R.sup.1 is hydrogen or lower alkyl and R.sup.2 is an olefinically unsaturated, electron-attracting, copolymerisable radical preferably having up to 25 carbon atoms, to crosslinked polymers, either homo- or co-polymers of those novel prepolymers, to processes for the preparation of the novel prepolymers and the homo- and co-polymers obtainable therefrom, to mouldings made from the said homo- or co-polymers, especially contact lenses made from those homo- or co-polymers, and to processes for the manufacture of contact lenses using the said homo- or co-polymers.

  本发明涉及一种新型的制造成型件的方法，特别是隐形眼镜，在该方法中，可交联基团的可溶性预聚物在溶液中交联，并且还涉及根据该方法获得的成型件，特别是隐形眼镜。本发明还涉及新型预聚物，可用于根据本发明的方法，特别是具有分子量至少约2000的聚乙烯醇的衍生物，根据聚乙烯醇的羟基数量，包含约0.5至约80％的式I的单元：其中R是具有最多8个碳原子的低烷基，R.sup.1是氢或低烷基，R.sup.2是烯烃不饱和，电子吸引，可共聚的基团，最好具有最多25个碳原子，交联聚合物，这些新型预聚物的同聚物或共聚物的制备方法以及从中获得的同聚物或共聚物制成的成型件，特别是由这些同聚物或共聚物制成的隐形眼镜，以及使用这些同聚物或共聚物制造隐形眼镜的方法。
• Gas hydrate formation inhibitor and method for inhibiting gas hydrate formation with the same
  申请人：——

  公开号：US20040024152A1

  公开（公告）日：2004-02-05

  A gas hydrate formation inhibitor consisting of an amphiphilic polymer (such as N-isopropylmethacrylamide (co)polymer) which bears nonionic groups (such as hydroxyl groups) at the polymerization-initiation and -termination ends and has a weight-average molecular weight of 500 to 10,000; and a method for inhibiting gas hydrate formation by adding the gas hydrate formation inhibitor to a system wherein a gas hydrate is to be formed. According to this invention, the formation of gas hydrates can be inhibited, and gas hydrates can be stabilized from the viewpoints of theories of chemical equilibrium and rate process.

  一种气体水合物形成抑制剂，由一种两性聚合物（例如N-异丙基甲基丙烯酰胺（共）聚合物）组成，该聚合物在聚合引发和终止端具有非离子基团（例如羟基），其重均分子量为500至10,000；以及一种通过向将形成气体水合物的系统中添加气体水合物形成抑制剂来抑制气体水合物形成的方法。根据本发明，可以抑制气体水合物的形成，并从化学平衡和速率过程的角度稳定气体水合物。
• Biomedical moldings
  申请人：Winterton Cook Lynn

  公开号：US20060079598A1

  公开（公告）日：2006-04-13

  The invention relates to a biomedical molding, in particular a contact lens, which is obtainable by crosslinking, in a mold, an aqueous solution of a crosslinkable polyvinyl alcohol (PVA) prepolymer comprising at least 0.5 weight-%, based on the entire formulation, of a non-reactive PVA, wherein the number-average molecular weight of the non-reactive PVA is higher than that of the crosslinkable PVA. A contact lens of the invention has an improved wearing comfort.

  本发明涉及一种生物医学成型物，特别是一种接触镜片，该接触镜片可通过在模具中交联交联性聚乙烯醇（PVA）预聚物的水溶液中加入至少0.5重量％（基于整个配方）的非反应性PVA，其中非反应性PVA的数量平均分子量高于交联性PVA。本发明的接触镜片具有改善的佩戴舒适性。