Fmoc-Ser-Asp(OtBu)-Lys(Boc)-ProOPp | 147221-41-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Fmoc-Ser-Asp(OtBu)-Lys(Boc)-ProOPp
• 英文别名: 2-phenylpropan-2-yl (2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxypropanoyl]amino]-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoyl]amino]-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoyl]pyrrolidine-2-carboxylate
• CAS: 147221-41-8
• 化学式: C₅₁H₆₇N₅O₁₂
• 分子量: 942.119
• InChiKey: WUIKZTZPTGLKRA-MFDNGWNGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  68
• 可旋转键数：
  25
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.51
• 拓扑面积：
  228
• 氢给体数：
  5
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  Fmoc-Ser-Asp(OtBu)-Lys(Boc)-ProOPp 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 以86%的产率得到Fmoc-Ser-Asp(OtBu)-Lys(Boc)-Pro-OH
  参考文献：
  名称：

  2-phenyl isopropyl esters as car☐yl terminus protecting groups in the fast synthesis of peptide fragments

  摘要：

  The esters of Fmoc aminoacids derived from 2-phenylisopropanol have been prepared by using 2-phenylisopropyltrichloroacetimidate 1. They prevent diketopiperazine formation during amino deprotection of dipeptides and can be cleaved in the presence of Boc and O-Bu(t). They are thus well suited for the protection of C-terminus when a Fmoc strategy is used to build up peptide fragments.

  DOI：

  10.1016/s0040-4039(00)60578-6
• 作为产物：
  描述：

  2,2,2-三氯亚氨基乙酸2-苯基丙烷-2-基酯 在 哌啶 、 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 环己烷 为溶剂， 反应 0.5h， 生成 Fmoc-Ser-Asp(OtBu)-Lys(Boc)-ProOPp
  参考文献：
  名称：

  2-phenyl isopropyl esters as car☐yl terminus protecting groups in the fast synthesis of peptide fragments

  摘要：

  The esters of Fmoc aminoacids derived from 2-phenylisopropanol have been prepared by using 2-phenylisopropyltrichloroacetimidate 1. They prevent diketopiperazine formation during amino deprotection of dipeptides and can be cleaved in the presence of Boc and O-Bu(t). They are thus well suited for the protection of C-terminus when a Fmoc strategy is used to build up peptide fragments.

  DOI：

  10.1016/s0040-4039(00)60578-6

文献信息

• 2-phenyl isopropyl esters as car☐yl terminus protecting groups in the fast synthesis of peptide fragments
  作者：Chongwei Yue、Josiane Thierry、Pierre Potier

  DOI：10.1016/s0040-4039(00)60578-6

  日期：1993.1

  The esters of Fmoc aminoacids derived from 2-phenylisopropanol have been prepared by using 2-phenylisopropyltrichloroacetimidate 1. They prevent diketopiperazine formation during amino deprotection of dipeptides and can be cleaved in the presence of Boc and O-Bu(t). They are thus well suited for the protection of C-terminus when a Fmoc strategy is used to build up peptide fragments.