Fmoc-Ser-Asp(OtBu)-Lys(Boc)-Pro-OH | 147221-42-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Fmoc-Ser-Asp(OtBu)-Lys(Boc)-Pro-OH
• 英文别名: Fmoc-Ser-Asp(OtBu)(OtBu)-Lys(Boc)-Pro-OH；(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxypropanoyl]amino]-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoyl]amino]-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoyl]pyrrolidine-2-carboxylic acid
• CAS: 147221-42-9
• 化学式: C₄₂H₅₇N₅O₁₂
• 分子量: 823.941
• InChiKey: VSNRZKABMUDIGX-YRCZKMHPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  59
• 可旋转键数：
  22
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  239
• 氢给体数：
  6
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  ProOPp 在 哌啶 、 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 Fmoc-Ser-Asp(OtBu)-Lys(Boc)-Pro-OH
  参考文献：
  名称：

  2-phenyl isopropyl esters as car☐yl terminus protecting groups in the fast synthesis of peptide fragments

  摘要：

  The esters of Fmoc aminoacids derived from 2-phenylisopropanol have been prepared by using 2-phenylisopropyltrichloroacetimidate 1. They prevent diketopiperazine formation during amino deprotection of dipeptides and can be cleaved in the presence of Boc and O-Bu(t). They are thus well suited for the protection of C-terminus when a Fmoc strategy is used to build up peptide fragments.

  DOI：

  10.1016/s0040-4039(00)60578-6

文献信息

• 2-phenyl isopropyl esters as car☐yl terminus protecting groups in the fast synthesis of peptide fragments
  作者：Chongwei Yue、Josiane Thierry、Pierre Potier

  DOI：10.1016/s0040-4039(00)60578-6

  日期：1993.1

  The esters of Fmoc aminoacids derived from 2-phenylisopropanol have been prepared by using 2-phenylisopropyltrichloroacetimidate 1. They prevent diketopiperazine formation during amino deprotection of dipeptides and can be cleaved in the presence of Boc and O-Bu(t). They are thus well suited for the protection of C-terminus when a Fmoc strategy is used to build up peptide fragments.