(S)-4-(2-[1,3,2]Dithiaphospholan-2-yl-ethyl)-2,2-dimethyl-[1,3]dioxolane | 1026352-42-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S)-4-(2-[1,3,2]Dithiaphospholan-2-yl-ethyl)-2,2-dimethyl-[1,3]dioxolane
• 英文别名: (4S)-4-[2-(1,3,2-dithiaphospholan-2-yl)ethyl]-2,2-dimethyl-1,3-dioxolane
• CAS: 1026352-42-0
• 化学式: C₉H₁₇O₂PS₂
• 分子量: 252.339
• InChiKey: SVVWLFGKGYJGKD-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  69.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (S)-4-(2-[1,3,2]Dithiaphospholan-2-yl-ethyl)-2,2-dimethyl-[1,3]dioxolane 在 1,2,3,4,5,6,7,8-八硫杂环辛烷 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙腈 、 苯 为溶剂， 反应 1.0h， 生成 2-[2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl-sulfidophosphinothioyl]oxyethyl-trimethylazanium
  参考文献：
  名称：

  General Route to Phosphonodithioic Acid Derivatives

  摘要：

  A general procedure for the synthesis of esters of phosphonodithioic acids has been developed. The method involves the reaction of the Grignard reagents 2a-h with 2-chloro-1,3,2-dithiaphospholane (1) to give 3a-h that were sulfurized using elemental sulfur to furnish the intermediate phosphonotrithioates 4a-h, reaction of which with a variety of alcohols in the presence of DBU furnished the desired phosphonodithioates 5a-h and 6-9.

  DOI：

  10.1021/jo00105a007
• 作为产物：
  描述：

  2-Chloro-1,3,2-dithiaphospholane 、 alkaline earth salt of/the/ methylsulfuric acid 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 (S)-4-(2-[1,3,2]Dithiaphospholan-2-yl-ethyl)-2,2-dimethyl-[1,3]dioxolane
  参考文献：
  名称：

  General Route to Phosphonodithioic Acid Derivatives

  摘要：

  A general procedure for the synthesis of esters of phosphonodithioic acids has been developed. The method involves the reaction of the Grignard reagents 2a-h with 2-chloro-1,3,2-dithiaphospholane (1) to give 3a-h that were sulfurized using elemental sulfur to furnish the intermediate phosphonotrithioates 4a-h, reaction of which with a variety of alcohols in the presence of DBU furnished the desired phosphonodithioates 5a-h and 6-9.

  DOI：

  10.1021/jo00105a007

文献信息

• General Route to Phosphonodithioic Acid Derivatives
  作者：Stephen F. Martin、Allan S. Wagman、G. Greg Zipp、Mikhail K. Gratchev

  DOI：10.1021/jo00105a007

  日期：1994.12

  A general procedure for the synthesis of esters of phosphonodithioic acids has been developed. The method involves the reaction of the Grignard reagents 2a-h with 2-chloro-1,3,2-dithiaphospholane (1) to give 3a-h that were sulfurized using elemental sulfur to furnish the intermediate phosphonotrithioates 4a-h, reaction of which with a variety of alcohols in the presence of DBU furnished the desired phosphonodithioates 5a-h and 6-9.