8-methoxy-2,5-dimethylquinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-methoxy-2,5-dimethylquinoline
• 英文别名: 2,5-dimethyl-8-methoxyquinoline
• 化学式: C₁₂H₁₃NO
• 分子量: 187.241
• InChiKey: QMLXKKFVQPSLHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8-methoxy-2,5-dimethylquinoline 在 镍 作用下， 以 丙醇 为溶剂， 80.0 ℃ 、919.92 MPa 条件下， 反应 4.0h， 以to yield 60% of 2,5-dimethyl-8-methoxy-1,2,3,4-tetrahydroquinoline的产率得到2,5-Dimethyl-8-methoxy-1,2,3,4-tetrahydroquinoline
  参考文献：
  名称：

  Colored toners containing dicyanomethine dye compounds

  摘要：

  本发明公开了一种静电复印色调剂，包括热塑性聚合物和一种四氢喹啉二氰甲烷黄色染料，其具有以下公式可溶于##STR1##其中R.sup.1和R.sup.2是低碳基，R.sup.3是低碳烷基，R.sup.4是4至8个碳原子的二羧亚胺基，苯并噻唑基-2-硫代烷基羧酸或4至18个碳原子的脂肪基羧酸，R.sup.5是4至10个碳原子的烷基或6至10个碳原子的芳基，X是...

  公开号：

  US04788121A1
• 作为产物：
  描述：

  2-甲氧基-5-甲基苯胺 、 巴豆醛 生成 8-methoxy-2,5-dimethylquinoline
  参考文献：
  名称：

  MOORE, WILLIAM H.

  摘要：

  DOI：

文献信息

• Iron-Catalyzed Direct Alkenylation of 2-Substituted Azaarenes with <i>N</i>-Sulfonyl Aldimines via C–H Bond Activation
  作者：Bo Qian、Pan Xie、Yinjun Xie、Hanmin Huang

  DOI：10.1021/ol200684b

  日期：2011.5.20

  A novel iron-catalyzed alkenylation of 2-substituted azaarenes through sp3 C–H bond activation has been developed. A favorable E2-elimination is proposed as a key step to cleavage of C–H and C–N bonds for the construction of a C═C bond in high stereoselectivity. This transformation represents an efficient way to synthesize 2-alkenylated azaarenes from simple starting materials.

  通过sp 3 C–H键活化，已开发出一种新型的铁催化的2-取代的氮杂芳烃的烯基化反应。提出了一种有利的消除E2的方法，作为裂解C–H和C–N键的关键步骤，以高立体选择性构建C═C键。这种转化代表了一种由简单的起始原料合成2-烯基化氮杂芳烃的有效方法。
• [EN] 1,3,5 -TRIAZINE-2-AMINE DERIVATIVES, PREPARATION THEREOF AND DIAGNOSTIC AND THERAPEUTIC USE THEREOF<br/>[FR] DÉRIVÉS DE 1,3,5-TRIAZINE-2-AMINE, PROCÉDÉ DE PRÉPARATION DE CEUX-CI ET UTILISATION DIAGNOSTIQUE ET THÉRAPEUTIQUE DE CES DÉRIVÉS
  申请人：SANOFI SA

  公开号：WO2013087643A1

  公开（公告）日：2013-06-20

  The present invention relates to compounds corresponding to formula (I) in which: - R1 represents a substituted phenyl; - R2 represents: - a substituted phenyl; - a heteroaromatic group, the said group being unsubstituted or substituted one or more times; - R3 represents a group Alk; - R4 represents a hydrogen atom or a (C1-C4)alkyl; - R5 represents a hydrogen atom, a (C3-C6)cycloalkyl or a (C1-C4)alkyl-O-Alk; - or alternatively R4 and R5, together with the nitrogen atom to which they are attached, constitute a heterocyclic radical chosen from: azetidin-1-yl, pyrrolidin-1-yl, piperid-1-yl, morpholin-4-yl; - R6 represents a group -COOAlk, a group -CONH 2 or a group -NHSO 2 Alk; - Alk represents a (C1-C4)alkyl, which is unsubstituted or substituted one or more times with a halogen atom; in the form of the base or of an acid-addition salt. Preparation process and diagnostic and therapeutic use.

  本发明涉及与以下式（I）对应的化合物：- R1代表取代苯基；- R2代表：- 取代苯基；- 杂芳基团，所述基团未取代或取代一次或多次；- R3代表羟基烷基基团；- R4代表氢原子或（C1-C4）烷基；- R5代表氢原子，（C3-C6）环烷基或（C1-C4）烷基-O-烷基；- 或者R4和R5，连同它们连接的氮原子，构成从以下中选择的杂环基团：氮杂环丙烷-1-基，吡咯烷-1-基，哌啶-1-基，吗啉-4-基；- R6代表-羟基烷基基团，-酰胺基或-NHSO2烷基基团；- 烷基代表未取代或取代一次或多次的（C1-C4）烷基，其上带有卤原子；以碱或酸盐的形式。制备过程和诊断和治疗用途。
• Substituted 5-acyl-3-carbamoyl-2-thienyl azo dyes with aniline,
  申请人：Eastman Kodak Company

  公开号：US04400318A1

  公开（公告）日：1983-08-23

  Disclosed are azo compounds having the formula ##STR1## in which R.sup.4 is straight or branched lower alkylene, Z is 1-3 groups selected from such heteroatom groups as --OH, lower alkanoyloxy, lower alkoxy, lower alkoxycarbonyl, lower alkoxyalkoxy, mono- or dialkylamino, --CN, carbamoyl, formamide, lower alkyl substituted carbamoyl, lower alkoxycarbonylamino, lower alkanoylamino, hydroxy substituted lower alkoxy, halogen, lower alkylthio, lower alkylsulfonyl, and various heterocyclic groups such as furyl and pyrrolidono, R is selected from straight or branched lower alkyl, phenyl and phenyl substituted with straight or branched lower alkyl, halogen, or straight or branched lower alkoxy, R.sup.2 is hydrogen or lower alkyl, and A is an aniline, tetrahydroquinoline, or benzomorpholine coupler component which may be substituted with a wide variety of groups. These azo compounds produce red to blue shades on polyamide, polyester and cellulose acetate fibers and exhibit markedly improved properties such as fastness and dyeability, particularly on synthetic polyamide fibers.

  揭示了具有以下式的偶氮化合物##STR1##其中R.sup.4是直链或支链低碳烷基，Z是1-3个从--OH、低脂肪酰氧基、低烷氧基、低烷氧羰基、低烷氧基氧基、单或二烷基氨基、--CN、氨基甲酰、甲酰胺、低烷基取代的甲酰胺、低烷氧羰胺基、低脂肪酰胺基、羟基取代的低烷氧基、卤素、低烷硫基、低烷基磺酰基以及各种杂环基团（如呋喃基和吡咯烷基），R选自直链或支链低烷基、苯基和苯基取代的直链或支链低烷基、卤素或直链或支链低烷氧基，R.sup.2是氢或低烷基，A是苯胺、四氢喹啉或苯基吗啉偶联组分，可以用各种基团取代。这些偶氮化合物在聚酰胺、聚酯和醋酸纤维上产生红色到蓝色的色调，并表现出明显改善的性能，如牢度和染色性，特别是对合成聚酰胺纤维。
• 1,3,5 -TRIAZINE-2-AMINE DERIVATIVES, PREPARATION THEREOF AND DIAGNOSTIC AND THERAPEUTIC USE THEREOF
  申请人：SANOFI

  公开号：EP2791120B1

  公开（公告）日：2016-02-24
• US20140343061A1
  申请人：——

  公开号：US20140343061A1

  公开（公告）日：2014-11-20