5-(2-{(4S,5R,6S)-6-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-ethanesulfonyl)-1-phenyl-1H-tetrazole | 725251-04-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(2-{(4S,5R,6S)-6-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-ethanesulfonyl)-1-phenyl-1H-tetrazole
• 英文别名: tert-butyl-diphenyl-[(2S)-2-[(4S,5R,6S)-2,2,5-trimethyl-6-[2-(1-phenyltetrazol-5-yl)sulfonylethyl]-1,3-dioxan-4-yl]propoxy]silane
• CAS: 725251-04-7
• 化学式: C₃₅H₄₆N₄O₅SSi
• 分子量: 662.926
• InChiKey: NWRABHYUJFXMGP-PDPQZYGGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  46
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  114
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (E)-(2R,4R,8S,11R)-11-[(4R,5R,6R)-6-(2-Benzyloxy-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-2,8-dimethoxy-4,7-dimethyl-dodec-6-enal 、 5-(2-{(4S,5R,6S)-6-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-ethanesulfonyl)-1-phenyl-1H-tetrazole 在 双(三甲基硅烷基)氨基钾 作用下， 以 乙二醇二甲醚 为溶剂， 生成 、
  参考文献：
  名称：

  Synthesis of the C1–C27 portion of the aplyronines

  摘要：

  This manuscript describes the use of the anti,anti-diastereoselective aldol reaction of an efficiently generated dipropionate equivalent to construct the C-5-C-14-portion of the aplyronines. This portion was then coupled with a compound corresponding to C-15-G(20) of the targets. Further elaboration and an additional coupling led to an intermediate containing C-1-C-27 with appropriate stereochemistry and functionalization for eventual conversion into the aplyronines. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.04.159
• 作为产物：
  描述：

  1-苯基-5-巯基四氮唑 在 ammonium molybdate 、 偶氮二甲酸二异丙酯 、 双氧水 、 三苯基膦 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成 5-(2-{(4S,5R,6S)-6-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-ethanesulfonyl)-1-phenyl-1H-tetrazole
  参考文献：
  名称：

  Synthesis of the C1–C27 portion of the aplyronines

  摘要：

  This manuscript describes the use of the anti,anti-diastereoselective aldol reaction of an efficiently generated dipropionate equivalent to construct the C-5-C-14-portion of the aplyronines. This portion was then coupled with a compound corresponding to C-15-G(20) of the targets. Further elaboration and an additional coupling led to an intermediate containing C-1-C-27 with appropriate stereochemistry and functionalization for eventual conversion into the aplyronines. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.04.159

文献信息

• Synthesis of the C1–C27 portion of the aplyronines
  作者：Michael A Calter、Jianguang Zhou

  DOI：10.1016/j.tetlet.2004.04.159

  日期：2004.6

  This manuscript describes the use of the anti,anti-diastereoselective aldol reaction of an efficiently generated dipropionate equivalent to construct the C-5-C-14-portion of the aplyronines. This portion was then coupled with a compound corresponding to C-15-G(20) of the targets. Further elaboration and an additional coupling led to an intermediate containing C-1-C-27 with appropriate stereochemistry and functionalization for eventual conversion into the aplyronines. (C) 2004 Elsevier Ltd. All rights reserved.