4-Hydroxyazulen | 58000-27-4

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 英文名称: 4-Hydroxyazulen
• 英文别名: 4-hydroxyazulene；azulen-4-ol
• CAS: 58000-27-4
• 化学式: C₁₀H₈O
• 分子量: 144.173
• InChiKey: IKTRNOZMSJUISH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-Hydroxyazulen 、 苯甲酰氯 生成 benzoic acid azulen-4-yl ester
  参考文献：
  名称：

  Azulene. I. An Improved Synthesis^1a,b

  摘要：

  DOI：

  10.1021/ja01145a080
• 作为产物：
  描述：

  cis,cis-4,4,9,9-Tetramethoxy-Δ^1,6-cyclodecadien 在 三氟化硼乙醚 作用下， 以 乙醚 为溶剂， 生成 4-Hydroxyazulen
  参考文献：
  名称：

  Shani,A., Israel Journal of Chemistry, 1975, vol. 13, p. 53 - 62

  摘要：

  DOI：

文献信息

• [EN] BENZOXAZEPIN COMPOUNDS SELECTIVE FOR PI3K P110 DELTA AND METHODS OF USE<br/>[FR] COMPOSÉS DE BENZOXAZÉPINE SÉLECTIFS POUR PI3K P110 DELTA ET LEURS MÉTHODES D'UTILISATION
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012126901A1

  公开（公告）日：2012-09-27

  Benzoxazepin Formula (I) compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula (I) for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

  BenzoxazePIn Formula (I) 化合物，包括立体异构体、几何异构体、互变异构体、代谢物和药学上可接受的盐，对于抑制PI3K的δ异构体以及治疗由脂质激酶介导的炎症、免疫性疾病和癌症是有用的。本文还揭示了使用Formula (I) 化合物在哺乳动物细胞中进行体外、体内和原位诊断、预防或治疗此类疾病或相关病理情况的方法。
• ORGANIC ELECTROLUMINESCENT DEVICE
  申请人：Soga Masayuki

  公开号：US20120199825A1

  公开（公告）日：2012-08-09

  An organic electroluminescent device comprising an anode, a cathode, a light emitting layer that is disposed between the anode and the cathode and contains a first light emitting layer material containing a phosphorescent compound and a second light emitting layer material containing a charge transporting polymer compound (that is, a light emitting layer containing a first light emitting layer material and a second light emitting layer material), and a hole transporting layer that is disposed between the anode and the light emitting layer so as to be adjacent to the light emitting layer and is composed of a hole transporting polymer compound, wherein the lowest excitation triplet energy T1 e (eV) of the first light emitting layer material, the lowest excitation triplet energy T1 h (eV) of the second light emitting layer material and the lowest excitation triplet energy T1 t (eV) of the hole transporting polymer compound satisfy the following formulae (A) and (B): T 1 e ≦T 1 h (A) T 1 t −T 1 e ≦0.10  (B). An organic electroluminescent device comprising an anode and a cathode, and a hole transporting layer and a light emitting layer disposed between the anode and the cathode, wherein the hole transporting layer contains 1) a mixture of 2,2′-bipyridine and/or 2,2′-bipyridine derivative and a non-2,2′-bipyridinediyl group-containing hole transporting polymer compound, 2) a 2,2′-bipyridinediyl group-containing polymer compound having a constitutional unit composed of an unsubstituted or substituted 2,2′-bipyridinediyl group, and at least one constitutional unit selected from the group consisting of constitutional units composed of a divalent aromatic amine residue and constitutional units composed of an unsubstituted or substituted arylene group, or a combination thereof.

  一种有机电致发光器件，包括阳极、阴极、位于阳极和阴极之间且含有第一发光层材料和第二发光层材料的发光层（即含有第一发光层材料和第二发光层材料的发光层），其中第一发光层材料含有磷光化合物，第二发光层材料含有电荷传输聚合物化合物，以及位于阳极和发光层之间以与发光层相邻的方式设置的孔传输层，由孔传输聚合物化合物组成，其中第一发光层材料的最低激发三重态能量T1e（eV）、第二发光层材料的最低激发三重态能量T1h（eV）和孔传输聚合物化合物的最低激发三重态能量T1t（eV）满足以下公式（A）和（B）：T1e≦T1h（A）T1t−T1e≦0.10（B）。一种有机电致发光器件，包括阳极和阴极、孔传输层和发光层，位于阳极和阴极之间，其中孔传输层包含1）2,2′-联吡啶和/或2,2′-联吡啶衍生物的混合物和不含2,2′-联吡啶基团的孔传输聚合物化合物，2）具有由未取代或取代的2,2′-联吡啶基团组成的构成单元和至少选自由双价芳香胺残基和由未取代或取代的芳基烃基组成的构成单元之一的构成单元的2,2′-联吡啶基团含量聚合物化合物，或其组合。
• ORGANIC ELECTROLUMINESCENT ELEMENT
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2492988A1

  公开（公告）日：2012-08-29

  An organic electroluminescent device comprising an anode, a cathode, a light emitting layer that is disposed between the anode and the cathode and contains a first light emitting layer material containing a phosphorescent compound and a second light emitting layer material containing a charge transporting polymer compound (that is, a light emitting layer containing a first light emitting layer material and a second light emitting layer material), and a hole transporting layer that is disposed between the anode and the light emitting layer so as to be adjacent to the light emitting layer and is composed of a hole transporting polymer compound, wherein the lowest excitation triplet energy T1e (eV) of the first light emitting layer material, the lowest excitation triplet energy T1h (eV) of the second light emitting layer material and the lowest excitation triplet energy T1t (eV) of the hole transporting polymer compound satisfy the following formulae (A) and (B): An organic electroluminescent device comprising an anode and a cathode, and a hole transporting layer and a light emitting layer disposed between the anode and the cathode, wherein the hole transporting layer contains 1) a mixture of 2,2'-bipyridine and/or 2,2'-bipyridine derivative and a non-2,2'-bipyridinediyl group-containing hole transporting polymer compound, 2) a 2,2'-bipyridinediyl group-containing polymer compound having a constitutional unit composed of an unsubstituted or substituted 2,2'-bipyridinediyl group, and at least one constitutional unit selected from the group consisting of constitutional units composed of a divalent aromatic amine residue and constitutional units composed of an unsubstituted or substituted arylene group, or a combination thereof.

  一种有机电致发光器件，包括阳极、阴极、位于阳极和阴极之间并包含含有磷光化合物的第一发光层材料和含有电荷传输聚合物化合物的第二发光层材料的发光层（即包含第一发光层材料和第二发光层材料的发光层）、以及一个空穴传输层，该层设置在阳极和发光层之间，与发光层相邻，由空穴传输高分子化合物组成，其中第一发光层材料的最低激发三重能 T1e（eV）、第二发光层材料的最低激发三重能 T1h（eV）和空穴传输高分子化合物的最低激发三重能 T1t（eV）满足下式（A）和（B）： 一种有机电致发光器件，包括阳极和阴极，以及设置在阳极和阴极之间的空穴传输层和发光层，其中空穴传输层包含 1) 2,2'-联吡啶和/或 2,2'-联吡啶衍生物与非 2,2'-联吡啶二基含空穴传输聚合物化合物的混合物，2) 2、2)一种含 2,2'-联吡啶二基的聚合物化合物，具有一个由未取代或取代的 2,2'-联吡啶二基组成的构型单元，以及至少一个选自由二价芳香族胺残基组成的构型单元和由未取代或取代的芳烯基组成的构型单元组成的组的构型单元，或它们的组合。
• Synthesis of 1,2-Azulenequinone Derivatives by Bromine-Oxidation
  作者：Hidetsugu Wakabayashi、Osamu Irinamihira、Satoshi Shibata、Teruo Kurihara、Yuzuru Uchiyama、Akira Ohta、Kunihide Fujimori

  DOI：10.3987/com-08-s(n)71

  日期：——

  Treatment of 2-hydroxyazulene (1a) with 3 equiv. of C(5)H(5)N center dot HBr(3) in aqueous THF-AcOH at 0 degrees C for 1 h afforded 1,1,3-tribromoazulene-2-one (5a). 3-Bromo-1,2-azulenequinone (2a) was obtained by the hydrolysis of 5a in the presence of Ag(2)O. Annulated compound 6 was readily obtained by the reaction of 2a with o-phenylenediamine.
• Shani, Israel Journal of Chemistry, 1975, vol. 13, p. 53,59
  作者：Shani

  DOI：——

  日期：——