N-[4-(1-oxo-2-methylpropane)phenyl]methanesulfonamide | 161526-22-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[4-(1-oxo-2-methylpropane)phenyl]methanesulfonamide
• 英文别名: N-[4-(2-methylpropanoyl)phenyl]methanesulfonamide
• CAS: 161526-22-3
• 化学式: C₁₁H₁₅NO₃S
• 分子量: 241.311
• InChiKey: RFAFYJVDDVPAFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  71.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-[4-(1-oxo-2-methylpropane)phenyl]methanesulfonamide 在 palladium on activated charcoal 盐酸 、 氢气 、 羟胺 、 sodium acetate 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Chain-branched 1,3-dibenzylthioureas as vanilloid receptor 1 antagonists

  摘要：

  A series of chain-branched 1,3-dibenzylthiourea derivatives were synthesized, and tested their antagonist activity against vanilloid receptor 1. Chain-branching led to a significant change in the mode of action and the potency. (R)-Methyl or ethyl-branched 1,3-dibenzylthiourea derivatives showed the most potent antagonist activity up to the IC50 value of 0.05 muM which is 10-fold more potent than capsazepine. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.01.066
• 作为产物：
  描述：

  N-苯基甲磺酰胺 、 异丁酰氯 在 三氯化铝 盐酸 作用下， 以 二氯甲烷 、 异丙醇 为溶剂， 生成 N-[4-(1-oxo-2-methylpropane)phenyl]methanesulfonamide
  参考文献：
  名称：

  Antiarrhythmic piperidin-1-yl-2,2-dialkylpropanone arylsulfonamide

  摘要：

  本发明涉及一类新型抗心律失常药物，其化学式为：##STR1## 其中，R代表氢、卤素、C.sub.1-4 烷基、C.sub.1-4 烷氧基、CF.sub.3、SR.sub.1、NHC(O)R.sub.2、NH.sub.2 或 OH；R.sub.1代表氢或C.sub.1-4 烷基；R.sub.2代表C.sub.1-4 烷基；X代表CO或CHOH；R.sub.3和R.sub.4分别独立地代表甲基、乙基、正丙基，或R.sub.3和R.sub.4与它们各自附着的碳原子形成一个C.sub.5或C.sub.6环烷基；Alk代表C.sub.1-4 烷基；或其药学上可接受的盐。

  公开号：

  US05541201A1

文献信息

• Heteroaryl Nitrile Compounds Useful as Inhibitors of Cathepsin-S
  申请人：Burke Michael J.

  公开号：US20130158018A1

  公开（公告）日：2013-06-20

  Disclosed are Cathepsin-S reversible inhibitor compounds of the formula (I) which are useful in the treatment of autoimmune and other diseases. Also disclosed are pharmaceutical compositions containing the same, and methods of making and using the same.
• US5541201A
  申请人：——

  公开号：US5541201A

  公开（公告）日：1996-07-30
• US8729114B2
  申请人：——

  公开号：US8729114B2

  公开（公告）日：2014-05-20
• Chain-branched 1,3-dibenzylthioureas as vanilloid receptor 1 antagonists
  作者：Chong Hyun Ryu、Mi Jung Jang、Jeong Wha Jung、Ju-Hyun Park、Hye Young Choi、Young-ger Suh、Uhtaek Oh、Hyeung-geun Park、Jeewoo Lee、Hyun-Joo Koh、Joo-Hyun Mo、Yung Hyup Joo、Young-Ho Park、Hee-Doo Kim

  DOI：10.1016/j.bmcl.2004.01.066

  日期：2004.4

  A series of chain-branched 1,3-dibenzylthiourea derivatives were synthesized, and tested their antagonist activity against vanilloid receptor 1. Chain-branching led to a significant change in the mode of action and the potency. (R)-Methyl or ethyl-branched 1,3-dibenzylthiourea derivatives showed the most potent antagonist activity up to the IC50 value of 0.05 muM which is 10-fold more potent than capsazepine. (C) 2004 Elsevier Ltd. All rights reserved.
• Antiarrhythmic piperidin-1-yl-2,2-dialkylpropanone arylsulfonamide
  申请人：Merrell Pharmaceuticals, Inc.

  公开号：US05541201A1

  公开（公告）日：1996-07-30

  The invention is directed to a new class of antiarrhythmic agents of the formula: ##STR1## in which R is represented by hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, CF.sub.3, SR.sub.1, NHC(O)R.sub.2, NH.sub.2, or OH; R.sub.1 is hydrogen or C.sub.1-4 alkyl; R.sub.2 is C.sub.1-4 alkyl; X is represented by CO or CHOH; R.sub.3 and R.sub.4 are each independently represented by methyl, ethyl, n-propyl, or R.sub.3 and R.sub.4 together with the carbon atom to which they each are attached form a C.sub.5 or C.sub.6 cycloalkyl; and Alk is a C.sub.1-4 alkyl; or a pharmaceutically acceptable addition salt thereof.

  本发明涉及一类新型抗心律失常药物，其化学式为：##STR1## 其中，R代表氢、卤素、C.sub.1-4 烷基、C.sub.1-4 烷氧基、CF.sub.3、SR.sub.1、NHC(O)R.sub.2、NH.sub.2 或 OH；R.sub.1代表氢或C.sub.1-4 烷基；R.sub.2代表C.sub.1-4 烷基；X代表CO或CHOH；R.sub.3和R.sub.4分别独立地代表甲基、乙基、正丙基，或R.sub.3和R.sub.4与它们各自附着的碳原子形成一个C.sub.5或C.sub.6环烷基；Alk代表C.sub.1-4 烷基；或其药学上可接受的盐。