2-Hydroxymethyl-4-methyl-tetrahydrofuran | 6906-52-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 2-Hydroxymethyl-4-methyl-tetrahydrofuran
• 英文别名: 4-Methyl-tetrahydrofurfurylalkohol；(4-methyl-tetrahydro-furan-2-yl)-methanol；(4-methyloxolan-2-yl)methanol
• CAS: 6906-52-1
• 化学式: C₆H₁₂O₂
• 分子量: 116.16
• InChiKey: FCHFDKDWVGHZMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Hydroxymethyl-4-methyl-tetrahydrofuran 在 phosphorus pentoxide 、 potassium 2-methylbutan-2-olate 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 5.83h， 生成 marmelo oxide
  参考文献：
  名称：

  Synthesis of (.+-.)-marmelo oxides by a radical cyclization reaction

  摘要：

  DOI：

  10.1021/jo00277a043
• 作为产物：
  描述：

  2-Allyloxy-3-bromo-propan-1-ol 在 偶氮二异丁腈 、 三丁基氯化锡 、 sodium cyanoborohydride 作用下， 以 叔丁醇 为溶剂， 反应 6.0h， 以43%的产率得到2-Hydroxymethyl-4-methyl-tetrahydrofuran
  参考文献：
  名称：

  Synthesis of (.+-.)-marmelo oxides by a radical cyclization reaction

  摘要：

  DOI：

  10.1021/jo00277a043

文献信息

• NEW AZABENZIMIDAZOLE DERIVATIVES
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20150119393A1

  公开（公告）日：2015-04-30

  The present invention relates to compounds of general formula I, wherein the group R 1 , R 2 , X, Y and z are defined as in claim 1 , which have valuable pharmacological properties, in particular bind to the AMP-activated protein kinase (AMPK) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

  本发明涉及一般式I的化合物，其中基团R1、R2、X、Y和z的定义如权利要求书中所述，具有有价值的药理特性，特别是结合AMP-活化蛋白激酶(AMPK)并调节其活性。这些化合物适用于治疗和预防可以受到该受体影响的疾病，如代谢性疾病，特别是2型糖尿病。
• METHOD FOR PRODUCING ALKANEDIOL
  申请人：Ube Industries, Ltd.

  公开号：EP2781498A1

  公开（公告）日：2014-09-24

  Provided by the present invention is a method for producing an alkanediol, such as 1,5-pentanediol, with a high reaction selectivity thereto by reacting a cyclic ether group-containing methanol such as tetrahydrofurfuryl alcohol by using a non-chromium catalyst not containing chromium atom. More specifically, the method is to produce an alkanediol having hydroxy groups at both molecular terminals shown by the formula (2), includes reacting a cyclic ether group-containing methanol shown by the formula (1) with hydrogen in the presence of a metal catalyst which contains copper atom, at least one co-existing atom selected from the group consisting of elements of the third to the sixth periods of the II to XIV groups (excluding chromium) in the periodical table and lanthanide elements.

  本发明提供了一种通过使用不含铬原子的非铬催化剂与含环醚基甲醇（如四氢糠醇）反应生产烷二醇（如1,5-戊二醇）的方法，该方法具有较高的反应选择性。更具体地说，该方法是生产一种在两个分子末端都有羟基的烷二醇，如式(2)所示，包括在含有铜原子、至少一个共存原子的金属催化剂存在下，使式(1)所示的含环醚基甲醇与氢反应，该金属催化剂选自周期表中第二至第十四族第三至第六周期的元素（不包括铬）和镧系元素组成的组。
• 5-SUBSTITUTED BENZIMIDAZOLE AND 5-SUBSTITUTED AZABENZIMIDAZOLE DERIVATIVE BOTH HAVING AMPK ACTIVATION EFFECT
  申请人：Shionogi & Co., Ltd

  公开号：EP3459949A1

  公开（公告）日：2019-03-27

  Provided is a compound which is useful as an AMPK activator. A compound represented by formula: wherein R1 is hydrogen, or substituted or unsubstituted alkyl; R2 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, or substituted or unsubstituted heterocyclyl; T is -CR5= or -N=; X is a single bond, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, or substituted or unsubstituted heterocyclyl; Y is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, or substituted or unsubstituted heterocyclyl; Z is RSRS'(O=)S=N-, RSRS'(O=)S=N-R2f-, RSRS'(O=)S=N-C(=O)-, (RN)N=S(=O)(RS)-, (RN)N=S(=O)(RS)-R2f-, RSRS'(RN'-N=)S=N-, or the like; n is an integer 1 or 2; RS and RS' are each independently substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, or the like; R2f is substituted or unsubstituted alkylene; RN is each independently hydrogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkylcarbonyl, or the like; RN' is hydrogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkyloxycarbonyl or the like; and R3, R4 and R5 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl, or the like, or its pharmaceutically acceptable salt.

  本文提供了一种可用作 AMPK 激活剂的化合物。一种由式表示的化合物： 其中 R1 是氢，或取代或未取代的烷基； R2是取代或未取代的烷基、取代或未取代的烯基、取代或未取代的炔基、取代或未取代的芳基、取代或未取代的杂芳基、取代或未取代的环烷基、取代或未取代的环烯基、取代或未取代的杂环基； T 是-CR5= 或-N=； X 是单键、取代或未取代的芳基、取代或未取代的杂芳基、取代或未取代的环烷基、取代或未取代的环烯基或取代或未取代的杂环基； Y 是取代或未取代的芳基、取代或未取代的杂芳基、取代或未取代的环烷基、取代或未取代的环烯基、或取代或未取代的杂环基； Z 是 RSRS'(O=)S=N-、RSRS'(O=)S=N-R2f-、RSRS'(O=)S=N-C(=O)-、(RN)N=S(=O)(RS)-、 (RN)N=S(=O)(RS)-R2f-，RSRS'(RN'-N=)S=N-，或类似成分； n 是整数 1 或 2； RS 和 RS'各自独立地是取代或未取代的烷基、取代或未取代的环烷基、取代或未取代的杂环烷基或类似物； R2f 是取代或未取代的亚烷基； RN 各独立地为氢、氰基、取代或未取代的烷基、取代或未取代的烷羰基或类似物； RN' 是氢、氰基、取代或未取代的烷基、取代或未取代的烷羰基、取代或未取代的烷氧羰基或类似物；以及 R3、R4 和 R5 各自独立地为氢、卤素、羟基、氰基、硝基、羧基、取代或未取代的烷基、取代或未取代的烯基、取代或未取代的炔基、取代或未取代的芳基、取代或未取代的杂芳基、取代或未取代的环烷基、取代或未取代的环烯基、取代或未取代的杂环基或类似物，或其药学上可接受的盐。
• SRIKRISHNA, A.;KRISHNAN, K., J. ORG. CHEM., 54,(1989) N6, C. 3981-3983
  作者：SRIKRISHNA, A.、KRISHNAN, K.

  DOI：——

  日期：——
• Catalyst and process for hydrogenating olefinically unsaturated compound
  申请人：JSR Corporation

  公开号：EP0974602B1

  公开（公告）日：2004-01-02