(6,7-dimethyl-1,4-dioxy-3-phenyl-quinoxalin-2-yl)-phenyl-methanone | 27017-88-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (6,7-dimethyl-1,4-dioxy-3-phenyl-quinoxalin-2-yl)-phenyl-methanone
• 英文别名: (6,7-Dimethyl-1-oxido-4-oxo-3-phenylquinoxalin-4-ium-2-yl)-phenylmethanone；(6,7-dimethyl-1-oxido-4-oxo-3-phenylquinoxalin-4-ium-2-yl)-phenylmethanone
• CAS: 27017-88-5
• 化学式: C₂₃H₁₈N₂O₃
• 分子量: 370.408
• InChiKey: RKGUSWWLHZHPGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  63.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二苯甲酰基甲烷 、 5,6-二甲基-1-氧代-2,1,3-苯并恶二唑-1-鎓 在 silica gel 作用下， 反应 0.03h， 以92%的产率得到(6,7-dimethyl-1,4-dioxy-3-phenyl-quinoxalin-2-yl)-phenyl-methanone
  参考文献：
  名称：

  Silica Gel Catalyzed Synthesis of Quinoxaline 1,4-Dioxides under Solvent-Free Conditions Using Microwave Irradiation

  摘要：

  We report on the simple and quick synthesis of quinoxaline 1,4-dioxides in solvent-free conditions under microwave irradiation. Heating of various benzofuroxans and beta-ketoesters or 1,3-diketones adsorbed on silica gel in a microwave oven for two minutes affords diverse biologically attractive quinoxaline 1,4-dioxides in high to excellent yields. Silica gel functions not only as support using microwave but also as catalyst and dehydration reagent.

  DOI：

  10.3987/com-08-11588

文献信息

• Silica Gel Catalyzed Synthesis of Quinoxaline 1,4-Dioxides under Solvent-Free Conditions Using Microwave Irradiation
  作者：Tohru Takabatake、Yusuke Sumiyoshi、Hiroaki Saito、Shinichi Miyairi

  DOI：10.3987/com-08-11588

  日期：——

  We report on the simple and quick synthesis of quinoxaline 1,4-dioxides in solvent-free conditions under microwave irradiation. Heating of various benzofuroxans and beta-ketoesters or 1,3-diketones adsorbed on silica gel in a microwave oven for two minutes affords diverse biologically attractive quinoxaline 1,4-dioxides in high to excellent yields. Silica gel functions not only as support using microwave but also as catalyst and dehydration reagent.