3-o-Chlorphenyl-4-acetyl-5-methylisoxazol | 35166-23-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-o-Chlorphenyl-4-acetyl-5-methylisoxazol
• 英文别名: 1-[3-(2-chloro-phenyl)-5-methyl-isoxazol-4-yl]-ethanone；1-[3-(2-Chlorophenyl)-5-methyl-1,2-oxazol-4-yl]ethanone
• CAS: 35166-23-5
• 化学式: C₁₂H₁₀ClNO₂
• 分子量: 235.67
• InChiKey: AIFDKUNUAVJLSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  43.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-o-Chlorphenyl-4-acetyl-5-methylisoxazol 在 溴 、 溶剂黄146 作用下， 以 四氯化碳 为溶剂， 反应 0.17h， 生成 2-Bromo-1-[3-(2-chloro-phenyl)-5-methyl-isoxazol-4-yl]-ethanone
  参考文献：
  名称：

  Chiarino, D.; Fantucci, M.; Sala, A., Journal of Heterocyclic Chemistry, 1988, vol. 25, p. 337 - 342

  摘要：

  DOI：

文献信息

• Synthesis of β-disubstituted β-amino isoxazolyl ketones by addition of ketimines with isoxazolyl methyl ketone enolates
  作者：Jason Guernon、Lawrence Marcin、Mendi Higgins、Fukang Yang、Jianliang Shi、Lawrence Snyder、Lorin A. Thompson、Yong-Jin Wu

  DOI：10.1016/j.tetlet.2014.02.053

  日期：2014.3

  A series of β-disubstituted N-sulfinyl β-amino isoxazolyl ketones has been prepared by addition of tert-butanesulfinyl ketimines with the n-BuLi-generated enolates of isoxazolyl methyl ketones.

  通过将叔丁烷亚磺酰基酮亚胺与异丁唑基甲基酮的n -BuLi生成的烯醇酸酯加成，可以制备一系列β-二取代的N-亚磺酰基β-氨基异恶唑基酮。
• Substituted pyrazoles as p38 kinase inhibitors
  申请人：Naraian S. Ashok

  公开号：US20070078146A1

  公开（公告）日：2007-04-05

  A class of pyrazole derivatives is described for use in treating p38 kinase medicated disorders. Compounds of particular interest are defined by Formula IA wherein R 1 , R 2 , R 3 and R 4 are as described in the specification.

  描述了一类吡唑衍生物，用于治疗p38激酶介导的疾病。特别感兴趣的化合物由公式IA定义，其中R1、R2、R3和R4如规范中所述。
• CHIARINO, D.;FANTUCCI, M.;SALA, A.;VENEZIANI, C., J. HETEROCYCL. CHEM., 25,(1988) N 1, 337-342
  作者：CHIARINO, D.、FANTUCCI, M.、SALA, A.、VENEZIANI, C.

  DOI：——

  日期：——
• USE OF 4-(ISOXAZOLYL)-THIAZOLE-2-OXAMIC ACID DERIVATIVES
  申请人：ZAMBON S.p.A.

  公开号：EP0191045A1

  公开（公告）日：1986-08-20
• Indanyl- and Tetrahydronaphtyl-amino-thiourea Compounds for Combating Animal Pests
  申请人：Kordes Markus

  公开号：US20090075819A1

  公开（公告）日：2009-03-19

  The present invention relates to Indanyl- and Tetrahydronaphtyl-amino-thiourea compounds of formula I wherein the variables R 1 to R 4 are as in the description. The invention relates also to methods of combating or controlling insects, arachnids or nematodes, to methods for protecting growing plants from attack or infestation by insects, arachnids or nematodes, to methods for the protection of seeds from soil insects and of the seedlings' roots and shoots from soil and foliar insects and to methods for treating, controlling, preventing or protecting animals against infestation or infection.