2-biphenyl-2-yl-chromen-4-one | 920286-90-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-biphenyl-2-yl-chromen-4-one
• 英文别名: 2-([1,1'-Biphenyl]-2-yl)-4H-1-benzopyran-4-one；2-(2-phenylphenyl)chromen-4-one
• CAS: 920286-90-4
• 化学式: C₂₁H₁₄O₂
• 分子量: 298.341
• InChiKey: ZOLDYNXRTFBUSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-溴苯甲酰氯 在 cesium fluoride lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 6.08h， 生成 2-biphenyl-2-yl-chromen-4-one
  参考文献：
  名称：

  Microwave enhanced palladium catalysed coupling reactions: A diversity-oriented synthesis approach to functionalised flavones

  摘要：

  引入了微波增强的多样性导向合成（MEDOS），采用钯催化的方案，作为系统修饰小分子合成的一种强大新策略，并通过功能化黄酮的应用进行了突出展示。

  DOI：

  10.1039/b610734f

文献信息

• US5773014A
  申请人：——

  公开号：US5773014A

  公开（公告）日：1998-06-30
• US6346255B1
  申请人：——

  公开号：US6346255B1

  公开（公告）日：2002-02-12
• [EN] PLANT POLAR LIPID PERMEATION ENHANCER IN A COSMETIC PAD FOR IMPROVING SKIN APPEARANCE<br/>[FR] ACTIVATEUR DE PENETRATION RENFERMANT UN LIPIDE POLAIRE VEGETAL DANS UN TIMBRE COSMETIQUE ET SERVANT A AMELIORER L'APPARENCE DE LA PEAU
  申请人：LAVIPHARM LABORATORIES, INC.

  公开号：WO1999036032A1

  公开（公告）日：1999-07-22

  (EN) A device for the improvement of skin appearance, comprising: a pad having a backing layer, a release layer, and a vehicle located therebetween, the vehicle including a cosmetic formulation and a skin permeation enhancer, wherein the skin permeation enhancer includes a plant polar lipid. A method of delivering a cosmetic agent to a topical target site for improving skin appearance, comprising: a composition for enhancing the penetration of agents through the outer layer of the skin, comprising: a preparation of plant polar lipid, the plant polar lipid containing at least one of a ceramide and a glycoceramide.(FR) L'invention concerne un dispositif servant à améliorer l'apparence de la peau, notamment: un timbre présentant une couche de support, une couche de libération, ainsi qu'un excipient situé entre celles-ci. L'excipient renferme une formulation cosmétique et un activateur de pénétration de la peau, ce dernier contenant un lipide polaire végétal. L'invention concerne un procédé d'administration d'un agent cosmétique vers un site topique cible en vue d'améliorer l'apparence de la peau, notamment: une composition servant à améliorer la pénétration d'agents à travers la couche extérieure de la peau, qui contient une préparation de lipide polaire végétal, le lipide polaire végétal renfermant un céramide et/ou un glycocéramide.
• [EN] COMPOSITIONS AND METHODS FOR COGNITIVE PROTECTION OF POLLINATORS AGAINST PESTICIDES<br/>[FR] COMPOSITIONS ET MÉTHODES DE PROTECTION COGNITIVE DE POLLINISATEURS CONTRE DES PESTICIDES
  申请人：UNIV ARIZONA

  公开号：WO2021046388A1

  公开（公告）日：2021-03-11

  Compositions and methods for protecting insect pollinators against the harmful cognitive effects of pesticides are disclosed. The compositions are suitable for administration to or ingestion by an insect pollinator and contain one or more phenolic compounds, such as the flavonoids quercetin, rutin, kaempferol and p-coumaric acid in an effective amount to protect against pesticide-induced impairment of a cognitive function of the insect pollinator. Methods of using such compositions for preventing or reducing pesticide-induced impairment of cognitive functions including learning, memory, decision-making, motor activity, and navigation in an insect pollinator are also provided. The compositions and methods protect insect pollinators including honeybees and bumblebees against neurotoxic pesticides with different pharmacodynamics including neonicotinoids, such as Imidacloprid, fipronil, and pyrethroids, such as deltamethrin.
• Microwave enhanced palladium catalysed coupling reactions: A diversity-oriented synthesis approach to functionalised flavones
  作者：Richard J. Fitzmaurice、Zac C. Etheridge、Emelie Jumel、Derek N. Woolfson、Stephen Caddick

  DOI：10.1039/b610734f

  日期：——

  Microwave enhanced diversity-oriented synthesis (MEDOS) using palladium catalysed protocols is introduced as a powerful new strategy for the synthesis of systematically modified small molecules and is highlighted by application to functionalised flavones.

  引入了微波增强的多样性导向合成（MEDOS），采用钯催化的方案，作为系统修饰小分子合成的一种强大新策略，并通过功能化黄酮的应用进行了突出展示。