4-[(4-aminomethyl)phenoxy]-2-pyridine carbonic acid methylamide | 685533-80-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-[(4-aminomethyl)phenoxy]-2-pyridine carbonic acid methylamide
• 英文别名: 4-[4-(aminomethyl)phenoxy]-N-methylpyridine-2-carboxamide
• CAS: 685533-80-6
• 化学式: C₁₄H₁₅N₃O₂
• mdl: MFCD16505924
• 分子量: 257.292
• InChiKey: MWOOZSDQWNBUOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  77.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-(4-Cyanophenoxy)-N-methyl-2-pyridinecarboxamide 在 镍 氨 、 氢气 作用下， 以 甲醇 为溶剂， 45.0 ℃ 、500.01 kPa 条件下， 以78%的产率得到4-[(4-aminomethyl)phenoxy]-2-pyridine carbonic acid methylamide
  参考文献：
  名称：

  [EN] METHYLENE UREA DERIVATIVES AS RAF-KINASE INHIBITORS
  [FR] DERIVES DE METHYLENE UREE

  摘要：

  公开号：

  WO2004037789A3

文献信息

• DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS
  申请人：Merck Patent GmbH

  公开号：US20150225369A1

  公开（公告）日：2015-08-13

  The present invention relates to compounds of the formula I and in particular medicaments comprising at least one compound of the formula I for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering of which DDR2 is involved, in particular for use in the treatment and/or prophylaxis of osteoarthritis, hepatocirrhosis, traumatic cartilage injuries, pain, allodynia or hyperalgesia.

  本发明涉及公式I的化合物，特别是包含至少一种公式I化合物的药物，用于治疗和/或预防生理和/或病理状态，其中触发DDR2参与，特别是用于治疗和/或预防骨关节炎、肝硬化、创伤性软骨损伤、疼痛、触痛或过敏性疼痛。
• METHYLENE UREA DERIVATIVES
  申请人：Buchstaller Hans-Peter

  公开号：US20090298885A1

  公开（公告）日：2009-12-03

  The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
• Methylene Urea Derivatives
  申请人：Merck Patent GmbH

  公开号：US20130158076A1

  公开（公告）日：2013-06-20

  The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
• US8410143B2
  申请人：——

  公开号：US8410143B2

  公开（公告）日：2013-04-02
• [EN] DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS<br/>[FR] INHIBITEURS DE DDR2 POUR LE TRAITEMENT DE L'ARTHROSE
  申请人：MERCK PATENT GMBH

  公开号：WO2014032755A2

  公开（公告）日：2014-03-06

  The present invention relates to compounds of the formula (I) and in particular medicaments comprising at least one compound of the formula (I) for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering of which DDR2 is involved, in particular for use in the treatment and/or prophylaxis of osteoarthritis, hepatocirrhosis, traumatic cartilage injuries, pain, allodynia or hyperalgesia.