2-(2-methoxy-ethyl)-5-phenyl-2H-[1,2,4]triazole-3-carbaldehyde | 1312301-16-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(2-methoxy-ethyl)-5-phenyl-2H-[1,2,4]triazole-3-carbaldehyde
• 英文别名: 2-(2-Methoxy-ethyl)-5-phenyl-2H-[1,2,4]triazole-3-carbaldehyde；2-(2-methoxyethyl)-5-phenyl-1,2,4-triazole-3-carbaldehyde
• CAS: 1312301-16-8
• 化学式: C₁₂H₁₃N₃O₂
• 分子量: 231.254
• InChiKey: CLNZASUHMXGBGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  57
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-苯基-2-恶唑啉-4-酮 在 palladium 10% on activated carbon 氢气 、 sodium hydride 、 戴斯-马丁氧化剂 、 三氟乙酸 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 20.0 ℃ 、600.01 kPa 条件下， 反应 2.16h， 生成 2-(2-methoxy-ethyl)-5-phenyl-2H-[1,2,4]triazole-3-carbaldehyde
  参考文献：
  名称：

  [EN] HETEROAROMATIC ARYL TRIAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS
  [FR] DÉRIVÉS HÉTÉROAROMATIQUES D'ARYLTRIAZOLE EN TANT QU'INHIBITEURS DE L'ENZYME PDE10A

  摘要：

  这项发明涉及化合物（式1），其为PDE10A酶抑制剂。该发明提供了一种包括本发明化合物的治疗有效量和药用可接受载体的药物组合物。本发明还提供了制备式（I）化合物的方法。本发明还提供了一种治疗患有神经退行性疾病的受试者的方法，包括向受试者施用化合物式（I）的治疗有效量。本发明还提供了一种治疗患有药物成瘾的受试者的方法，包括向受试者施用化合物式（I）的治疗有效量。本发明还提供了一种治疗患有精神障碍的受试者的方法，包括向受试者施用化合物式（I）的治疗有效量。

  公开号：

  WO2011072697A1

文献信息

• Heteroaromatic aryl triazole derivatives as PDE10A enzyme inhibitors
  申请人：Püschl Ask

  公开号：US20120309764A1

  公开（公告）日：2012-12-06

  This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.

  本发明涉及一种PDE10A酶抑制剂化合物。本发明提供一种药物组合物，包括本发明化合物的治疗有效量和药学上可接受的载体。本发明还提供了制备式I化合物的方法。本发明还提供了一种治疗神经退行性疾病的方法，包括向患者施用式I化合物的治疗有效量。本发明还提供了一种治疗药物成瘾的方法，包括向患者施用式I化合物的治疗有效量。本发明还提供了一种治疗精神障碍的方法，包括向患者施用式I化合物的治疗有效量。
• Heteroaromatic Aryl Triazole Derivatives as PDE10A Enzyme Inhibitors
  申请人：H. Lundbeck A/S

  公开号：US20130281459A1

  公开（公告）日：2013-10-24

  This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.

  本发明涉及一种PDE10A酶抑制剂化合物。本发明提供了一种制药组合物，包括本发明化合物的治疗有效量和药学上可接受的载体。本发明还提供了制备式I化合物的方法。本发明还提供了一种治疗神经退行性疾病的方法，包括向患者施用式I化合物的治疗有效量。本发明还提供了一种治疗药物成瘾的方法，包括向患者施用式I化合物的治疗有效量。本发明还提供了一种治疗精神障碍的方法，包括向患者施用式I化合物的治疗有效量。
• (3-aryl-1H-1,2,4-triazol-5-yl)-linked heterocycle derivatives
  申请人：Püschl Ask

  公开号：US08501795B2

  公开（公告）日：2013-08-06

  This invention is directed to compounds of formula I having the structure which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.

  本发明涉及具有以下结构的公式I化合物，其为PDE10A酶抑制剂。该发明提供了一种制药组合物，包括本发明化合物的治疗有效量和药学上可接受的载体。本发明还提供了制备公式I化合物的方法。本发明还提供了一种治疗神经退行性疾病的方法，包括向患者施用公式I化合物的治疗有效量。本发明还提供了一种治疗药物成瘾的方法，包括向患者施用公式I化合物的治疗有效量。本发明还提供了一种治疗精神障碍的方法，包括向患者施用公式I化合物的治疗有效量。
• HETEROAROMATIC ARYL TRIAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS
  申请人：H. Lundbeck A/S

  公开号：EP2513106A1

  公开（公告）日：2012-10-24
• US8501795B2
  申请人：——

  公开号：US8501795B2

  公开（公告）日：2013-08-06