3-(2-quinolinideneamino)quinoline | 16722-44-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(2-quinolinideneamino)quinoline
• 英文别名: 3-<(2-Chinolylmethylen)-amino>-chinolin；quinolin-3-yl-quinolin-2-ylmethylene-amine；3-Quinolinamine, N-(2-quinolinylmethylene)-；1-quinolin-2-yl-N-quinolin-3-ylmethanimine
• CAS: 16722-44-4
• 化学式: C₁₉H₁₃N₃
• 分子量: 283.332
• InChiKey: FOOVLXYORBIGKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(2-quinolinideneamino)quinoline 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以80%的产率得到3-<(quinolin-2-ylmethyl)amino>quinoline
  参考文献：
  名称：

  Formation of (N-Heteroaryl)heteroarymethanamines from Heteroaromatic Aldehydes and Heteroaromatic Amines

  摘要：

  The reactions of heteroaromatic aldehydes with heteroaromatic amines show significant differences depending on the heteroaromatic moieties present both in the aldehydes and in the amines, giving imines (3) or [bis-(heteroarylamino)methyl]arenes (5). The direct formation of (N-heteroaryl)heteroarylmethanamines (4) is achieved by the Leuckart-Wallach reaction. Reaction conditions for the formation of amines (4) by NaBH4 reduction of imines (3) are also reported.

  DOI：

  10.3987/com-93-s109
• 作为产物：
  描述：

  喹啉-2-甲醛 、 3-氨基喹啉 以 乙醇 为溶剂， 反应 0.33h， 以76%的产率得到3-(2-quinolinideneamino)quinoline
  参考文献：
  名称：

  Formation of (N-Heteroaryl)heteroarymethanamines from Heteroaromatic Aldehydes and Heteroaromatic Amines

  摘要：

  The reactions of heteroaromatic aldehydes with heteroaromatic amines show significant differences depending on the heteroaromatic moieties present both in the aldehydes and in the amines, giving imines (3) or [bis-(heteroarylamino)methyl]arenes (5). The direct formation of (N-heteroaryl)heteroarylmethanamines (4) is achieved by the Leuckart-Wallach reaction. Reaction conditions for the formation of amines (4) by NaBH4 reduction of imines (3) are also reported.

  DOI：

  10.3987/com-93-s109

文献信息

• Design, synthesis and antimycotic activity of (N-heteroaryl)arylmethanamines
  作者：Alberto Ballistreri、Alessandra Bottino、Giuseppe Musumarra、Rossella Fioravanti、Mariangela Biava、Giulio Cesare Porretta、Nicola Simonetti、Adelaide Villa

  DOI：10.1002/(sici)1099-1395(199602)9:2<61::aid-poc748>3.0.co;2-r

  日期：1996.2
• Formation of (N-Heteroaryl)heteroarymethanamines from Heteroaromatic Aldehydes and Heteroaromatic Amines
  作者：Giuseppe Musumarra、Caterina Sergi

  DOI：10.3987/com-93-s109

  日期：——

  The reactions of heteroaromatic aldehydes with heteroaromatic amines show significant differences depending on the heteroaromatic moieties present both in the aldehydes and in the amines, giving imines (3) or [bis-(heteroarylamino)methyl]arenes (5). The direct formation of (N-heteroaryl)heteroarylmethanamines (4) is achieved by the Leuckart-Wallach reaction. Reaction conditions for the formation of amines (4) by NaBH4 reduction of imines (3) are also reported.