1-(3,5-dihydroxy-4-methylphenyl)ethanone | 855925-40-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(3,5-dihydroxy-4-methylphenyl)ethanone
• 英文别名: 1-(3,5-Dihydroxy-4-methyl-phenyl)-aethanon
• CAS: 855925-40-5
• 化学式: C₉H₁₀O₃
• 分子量: 166.177
• InChiKey: VOCZEYOHTDAHEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(3,5-dihydroxy-4-methylphenyl)ethanone 在 N-溴代丁二酰亚胺(NBS) 、 potassium carbonate 作用下， 以 二甲基亚砜 、 乙腈 为溶剂， 反应 25.0h， 生成 1-(2-bromo-5-hydroxy-3-methoxy-4-methylphenyl)ethanone
  参考文献：
  名称：

  通过仿生方法催化对映体选择性合成海事碱A和相关的异吲哚啉酮

  摘要：

  异吲哚啉酮的催化对映选择性合成是通过2酰基苯甲醛和苯胺的缩合实现的。在1mol％的手性磷酸催化剂的存在下，反应在10分钟内完成，并提供具有高达98％ee的产物。具有邻叔丁基的苯胺形成阻转异构体产物，从而能够从两个非手性底物同时产生轴向和点手性。该方法被用于第一次合成的海水line。

  DOI：

  10.1002/anie.201709182
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 作用下， 生成 1-(3,5-dihydroxy-4-methylphenyl)ethanone
  参考文献：
  名称：

  A CONTRIBUTION TO THE STRUCTURE OF CITRININ

  摘要：

  DOI：

  10.1021/jo01155a010

文献信息

• Johnson et al., Journal of the Chemical Society, 1950, p. 2971,2973
  作者：Johnson et al.

  DOI：——

  日期：——
• GLUCOSYLTRANSFERASE INHIBITOR CONTAINING EPIGALLOCATECHIN GALLATE POLYMER AS ACTIVE INGREDIENT
  申请人：Fukui Yuko

  公开号：US20110150790A1

  公开（公告）日：2011-06-23

  Provided is a highly palatable and safe glucosyltransferase inhibitor or anti-dental caries agent. A glucosyltransferase inhibitor or anti-dental caries agent having an epigallocatechin gallate polymer or a salt thereof. Particularly, the above agent containing an epigallocatechin gallate polymer, which is a compound in which chroman rings are bonded at position 6 and/or 8 via a methylene group.
• PROANTHOCYANIDIN OF CASHEW APPLE, COMPOSITION CONTAINING PROANTHOCYANIDIN, AND APPLICATION THEREOF
  申请人：Nagamine Kenichi

  公开号：US20110263698A1

  公开（公告）日：2011-10-27

  This invention provides useful applications of cashew apple. This invention also provides a naturally occurring active ingredient having useful activities, such as alpha-amylase inhibitory activity, lipase inhibitory activity, and antibacterial activity against Propionibacterium acnes . The invention also provides a composition containing cashew apple-derived proanthocyanidin having excellent alpha-amylase inhibitory activity, lipase inhibitory activity, and antibacterial activity against Propionibacterium acnes , which is prepared by allowing a plant fiber-degrading enzyme (e.g., pectinase) to react with a cashew apple and concentrating the resultant with the use of an ultrafiltration membrane. Further, the invention provides a proanthocyanidin compound having a novel structure.
• METHODS AND COMPOSITIONS FOR TREATMENT OF ISCHEMIC CONDITIONS AND CONDITIONS RELATED TO MITOCHONDRIAL FUNCTION
  申请人：Villareal Francisco

  公开号：US20120095063A1

  公开（公告）日：2012-04-19

  The present invention relates to compositions and methods for prophylactic and/or therapeutic treatment of conditions related to mitochondrial function. In various aspects, the present invention comprises administering one or more compounds selected from the group consisting of epicatechin, an epicatechin derivative, catechin, a catechin derivative, nicorandil, and a nicorandil derivative in an amount effective to stimulate mitochondrial function in cells. The methods and compositions described herein provide for reducing infarct size in the heart following permanent ischemia or ischemia/reperfusion (IR) event or method for delaying, attenuating or preventing adverse cardiac remodeling, and can assist in prevention of impaired mitochondria biogenesis and thus prevention of the consequences of impaired mitochondrial biogenesis in various diseases and conditions, as well as provide for the active therapy of mitochondrial depletion that may have already occurred.
• US8575368B2
  申请人：——

  公开号：US8575368B2

  公开（公告）日：2013-11-05