(E)-2-oxo-4-phenyl-N-p-tolylbut-3-enamide | 1203605-80-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-2-oxo-4-phenyl-N-p-tolylbut-3-enamide
• 英文别名: (E)-N-(4-methylphenyl)-2-oxo-4-phenylbut-3-enamide
• CAS: 1203605-80-4
• 化学式: C₁₇H₁₅NO₂
• 分子量: 265.312
• InChiKey: UJMGOBMJTDASOE-FMIVXFBMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (E)-but-1-en-3-yn-1-ylbenzene 、 乙烷,三氯氟- 在 吡啶 、 2,2,6,6-四甲基哌啶氧化物 、 水 、 氧气 、 copper(ll) bromide 作用下， 以 甲苯 为溶剂， 60.0 ℃ 、101.33 kPa 条件下， 反应 18.0h， 以65%的产率得到(E)-2-oxo-4-phenyl-N-p-tolylbut-3-enamide
  参考文献：
  名称：

  Dioxygen Activation under Ambient Conditions: Cu-Catalyzed Oxidative Amidation−Diketonization of Terminal Alkynes Leading to α-Ketoamides

  摘要：

  A novel Cu-catalyzed oxidative amidation-diketonization reaction of terminal alkynes leading to alpha-ketoamides has been developed. This chemistry offers a valuable mechanistic insight into this novel Cu catalysis via a radical process. O-2 not only participates as the ideal oxidant but also undergoes dioxygen activation under ambient conditions in this transformation.

  DOI：

  10.1021/ja908911n

文献信息

• Dioxygen Activation under Ambient Conditions: Cu-Catalyzed Oxidative Amidation−Diketonization of Terminal Alkynes Leading to α-Ketoamides
  作者：Chun Zhang、Ning Jiao

  DOI：10.1021/ja908911n

  日期：2010.1.13

  A novel Cu-catalyzed oxidative amidation-diketonization reaction of terminal alkynes leading to alpha-ketoamides has been developed. This chemistry offers a valuable mechanistic insight into this novel Cu catalysis via a radical process. O-2 not only participates as the ideal oxidant but also undergoes dioxygen activation under ambient conditions in this transformation.