dibenzyl 2-[2-(4-methoxyphenyl)-3-methyl-4-oxo-4-phenylbutyl]malonate | 1089671-91-9

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: dibenzyl 2-[2-(4-methoxyphenyl)-3-methyl-4-oxo-4-phenylbutyl]malonate
• 英文别名: Dibenzyl 2-[2-(4-methoxyphenyl)-3-methyl-4-oxo-4-phenylbutyl]propanedioate
• CAS: 1089671-91-9
• 化学式: C₃₅H₃₄O₆
• 分子量: 550.651
• InChiKey: JBPOXOCRKQSFBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  41
• 可旋转键数：
  15
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-phenyl-1-trimethylsiloxypropene 、 dibenzyl 2-(4-methoxyphenyl)cyclopropane-1,1-dicarboxylate 在 scandium tris(trifluoromethanesulfonate) 作用下， 以 二氯甲烷 为溶剂， 以99%的产率得到dibenzyl 2-[2-(4-methoxyphenyl)-3-methyl-4-oxo-4-phenylbutyl]malonate
  参考文献：
  名称：

  Sc(OTf)3-catalyzed smooth tandem [3+2] cycloaddition/ring opening of donor–acceptor cyclopropane 1,1-diesters with enol silyl ethers

  摘要：

  Catalyzed by Lewis acids, donor-acceptor cyclopropane 1,1-diesters reacted with enol silyl ethers to afford 1,6-dicarbonyl compounds in moderate to excellent yields. This supplied a mild carbon-carbon bond-forming method from the ring opening of cyclopropanes. A smooth tandem [3+2] cycloaddition/ring opening process has been clearly proved by an independent experiment. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.09.028

文献信息

• Sc(OTf)3-catalyzed smooth tandem [3+2] cycloaddition/ring opening of donor–acceptor cyclopropane 1,1-diesters with enol silyl ethers
  作者：Jie Fang、Jun Ren、Zhongwen Wang

  DOI：10.1016/j.tetlet.2008.09.028

  日期：2008.11

  Catalyzed by Lewis acids, donor-acceptor cyclopropane 1,1-diesters reacted with enol silyl ethers to afford 1,6-dicarbonyl compounds in moderate to excellent yields. This supplied a mild carbon-carbon bond-forming method from the ring opening of cyclopropanes. A smooth tandem [3+2] cycloaddition/ring opening process has been clearly proved by an independent experiment. (C) 2008 Elsevier Ltd. All rights reserved.