(5,11-Dimethyl-6H-pyrido[4,3-b]carbazol-9-yl)-methanol | 188258-24-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (5,11-Dimethyl-6H-pyrido[4,3-b]carbazol-9-yl)-methanol
• 英文别名: (5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-yl)methanol
• CAS: 188258-24-4
• 化学式: C₁₈H₁₆N₂O
• 分子量: 276.338
• InChiKey: BLXMRBDANRAFTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  48.9
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (5,11-Dimethyl-6H-pyrido[4,3-b]carbazol-9-yl)-methanol 在 氢溴酸 、 溶剂黄146 作用下， 反应 1.0h， 生成 9-Bromomethyl-5,11-dimethyl-6H-pyrido[4,3-b]carbazole
  参考文献：
  名称：

  Selective cytotoxicity of certain 9-substituted ellipticines for leukemia cells in a variety of leukemia cell cultures

  摘要：

  Certain 9-substituted ellipticines, including 9-hydroxymethylellipticine, displayed selective in vitro cytotoxicity for leukemia cells in a variety of leukemia cell cultures. The selective cytotoxicity was apparent in all of the leukemia cell lines examined, which included CCRF-CEM, HL-60 (TB), K-562, MOLT-4, RPMI-8226, and SR cells. (C) 1997, Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00021-8
• 作为产物：
  描述：

  9-formylellipticine 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 1.0h， 生成 (5,11-Dimethyl-6H-pyrido[4,3-b]carbazol-9-yl)-methanol
  参考文献：
  名称：

  Selective cytotoxicity of certain 9-substituted ellipticines for leukemia cells in a variety of leukemia cell cultures

  摘要：

  Certain 9-substituted ellipticines, including 9-hydroxymethylellipticine, displayed selective in vitro cytotoxicity for leukemia cells in a variety of leukemia cell cultures. The selective cytotoxicity was apparent in all of the leukemia cell lines examined, which included CCRF-CEM, HL-60 (TB), K-562, MOLT-4, RPMI-8226, and SR cells. (C) 1997, Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00021-8

文献信息

• Selective cytotoxicity of certain 9-substituted ellipticines for leukemia cells in a variety of leukemia cell cultures
  作者：Rajesh Devraj、Mark Cushman

  DOI：10.1016/s0960-894x(97)00021-8

  日期：1997.2

  Certain 9-substituted ellipticines, including 9-hydroxymethylellipticine, displayed selective in vitro cytotoxicity for leukemia cells in a variety of leukemia cell cultures. The selective cytotoxicity was apparent in all of the leukemia cell lines examined, which included CCRF-CEM, HL-60 (TB), K-562, MOLT-4, RPMI-8226, and SR cells. (C) 1997, Elsevier Science Ltd.