1-(3-Ethoxycarbonyl-propyl)-4-methyl-quinolinium | 736924-49-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(3-Ethoxycarbonyl-propyl)-4-methyl-quinolinium
• 英文别名: Ethyl 4-(4-methylquinolin-1-ium-1-yl)butanoate
• CAS: 736924-49-5
• 化学式: C₁₆H₂₀NO₂
• 分子量: 258.34
• InChiKey: CIRALXKKMDTGGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(3-Ethoxycarbonyl-propyl)-4-methyl-quinolinium 在 sodium hydroxide 、 碳酸氢钠 、 1-羟基苯并三唑 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 乙醇 为溶剂， 反应 25.0h， 生成 N-[[(2S,3S,4R,5R,6R)-5-amino-6-[(2R,3S,4R,5S)-5-[(1R,2R,3S,5R,6S)-3,5-diamino-2-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy-3,4-dihydroxyoxan-2-yl]methyl]-4-[4-[(3-methyl-1,3-benzothiazol-2-ylidene)methyl]quinolin-1-ium-1-yl]butanamide
  参考文献：
  名称：

  Aminoglycoside hybrids as potent RNA antagonists

  摘要：

  Aminoglycosides specifically bind to the A-site decoding region of prokaryotic 16S rRNA with dissociation constants in the 1-2 mu M range. The aminoglycoside paromomycin binds to a truncated A-site construct with a K-d = 1.85 mu M. Paromomycin analogs are described here in which the aminoglycoside is linked via spacer groups to either thiazole orange or pyrene. These analogs bind specifically to the truncated A-site construct, but with affinities considerably higher than paromomycin itself. The binding of the hybrid molecules to the A-site is greater the shorter the spacer group. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00240-9
• 作为产物：
  描述：

  4-溴丁酸乙酯 在 sodium iodide 作用下， 以 1,4-二氧六环 、 丙酮 为溶剂， 反应 1.0h， 生成 1-(3-Ethoxycarbonyl-propyl)-4-methyl-quinolinium
  参考文献：
  名称：

  Aminoglycoside hybrids as potent RNA antagonists

  摘要：

  Aminoglycosides specifically bind to the A-site decoding region of prokaryotic 16S rRNA with dissociation constants in the 1-2 mu M range. The aminoglycoside paromomycin binds to a truncated A-site construct with a K-d = 1.85 mu M. Paromomycin analogs are described here in which the aminoglycoside is linked via spacer groups to either thiazole orange or pyrene. These analogs bind specifically to the truncated A-site construct, but with affinities considerably higher than paromomycin itself. The binding of the hybrid molecules to the A-site is greater the shorter the spacer group. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00240-9

文献信息

• ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS
  申请人：MAO FEI

  公开号：US20120115129A1

  公开（公告）日：2012-05-10

  Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.

  本发明提供了酶底物及其相关技术。本发明的酶底物可以包括生物学功能荧光染料和酶特异性底物基团，以一种降低功能染料功能的方式连接。酶催化反应可以从酶底物中至少裂解一部分底物基团，以提供更具功能的产物染料。这种产物染料通常是非荧光或弱荧光的，在特定条件下，如与伴侣生物分子或伴侣生物分子组装结合时，相对荧光。因此，本发明的酶底物可以用于荧光检测，以及各种有用的应用，如在无细胞体系或活细胞中检测酶活性，筛选药物或诊断疾病。
• US20140273151A1
  申请人：——

  公开号：US20140273151A1

  公开（公告）日：2014-09-18
• US8092784B2
  申请人：——

  公开号：US8092784B2

  公开（公告）日：2012-01-10
• US8586325B2
  申请人：——

  公开号：US8586325B2

  公开（公告）日：2013-11-19
• US8778627B2
  申请人：——

  公开号：US8778627B2

  公开（公告）日：2014-07-15