dodecyl-octyl ether | 36339-51-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: dodecyl-octyl ether
• 英文别名: Dodecyl-octyl-aether；octyl dodecanol；Dodecyl octyl ether；1-octoxydodecane
• CAS: 36339-51-2
• 化学式: C₂₀H₄₂O
• 分子量: 298.553
• InChiKey: MMMPXNOKIZOWHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.1
• 重原子数：
  21
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  辛酸钠 、 溴代十二烷 在 辛醇 作用下， 生成 dodecyl-octyl ether
  参考文献：
  名称：

  Preparation and Properties of Some Octyl Ethers¹

  摘要：

  DOI：

  10.1021/ja01115a508

文献信息

• ANTI-TUMOR EFFECT POTENTIATOR
  申请人：Fukuoka Masayoshi

  公开号：US20120225838A1

  公开（公告）日：2012-09-06

  There is provided an agent for potentiating the effects of an anti-tumor agent. An anti-tumor effect potentiator containing, as an active ingredient, a uracil compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein X represents a C 1-5 alkylene group and one of methylene groups constituting the alkylene group is optionally substituted with an oxygen atom; R 1 represents a hydrogen atom or a C 1-6 alkyl group; R 2 represents a hydrogen atom or a halogen atom; and R 3 represents a C 1-6 alkyl group, a C 2-6 alkenyl group, a C 3-6 cycloalkyl group, a (C 3-6 cycloalkyl) C 1-6 alkyl group, a halogeno-C 1-6 alkyl group or a saturated heterocyclic group.

  提供了一种用于增强抗肿瘤药物效果的药剂。 一种抗肿瘤效应增强剂，其包含以下式(I)所代表的尿嘧啶化合物或其药用可接受的盐作为活性成分： 其中X代表一个C1-5烷基基团，构成该烷基基团的亚甲基基团之一可以选择性地被氧原子取代； R1代表氢原子或一个C1-6烷基基团；R2代表氢原子或卤原子；R3代表一个C1-6烷基基团，一个C2-6烯基基团，一个C3-6环烷基基团，一个(C3-6环烷基)C1-6烷基基团，一个卤代C1-6烷基基团或一个饱和杂环基团。
• Cyclic diamine compound with condensed-ring groups
  申请人：Kowa Co., Ltd.

  公开号：US20030060461A1

  公开（公告）日：2003-03-27

  A cyclic diamine compound of formula (1): 1 wherein R 1 and R 2 are individually a hydrogen atom or a methoxy group, provided R 1 is a methoxy group when R 2 is a hydrogen atom, or a hydrogen atom when R 2 is a methoxy group; A is an oxygen atom, a sulfur atom, CH═CH, CH═N or NR 3 , in which R 3 is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, aryl or aryl lower alkyl group; B is a nitrogen atom, CH or CR 4 , in which R 4 is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, aryl or aryl lower alkyl group; m is 1 or 2; and n is a number of 1 to 5, an acid-addition salt thereof, or a hydrate thereof. The compound has inhibitory effects on cell adhesion and is useful for treatment of allergy, asthma, rheumatism, arteriosclerosis, and inflammation.

  公式（1）所示的环状二胺化合物：1 其中R1和R2分别是个别氢原子或甲氧基，条件是当R2是氢原子时R1是甲氧基，或者当R2是甲氧基时R1是氢原子；A是氧原子、硫原子、CH═CH、CH═N或NR3，其中R3是氢原子，或者是低级烷基、羟基低级烷基、低级烷氧基低级烷基、芳基或芳基低级烷基团；B是氮原子、CH或CR4，其中R4是氢原子，或者是低级烷基、羟基低级烷基、低级烷氧基低级烷基、芳基或芳基低级烷基团；m是1或2；n是1到5的数字，其酸加成盐，或其水合物。该化合物具有抑制细胞粘附的作用，并且对于治疗过敏、哮喘、风湿病、动脉硬化以及炎症是有用的。
• Cyclic amine compounds and pharmaceutical composition containing the same
  申请人：KOWA CO., LTD.

  公开号：US20040010147A1

  公开（公告）日：2004-01-15

  A cyclic amine compound represented by the following general formula (1): 1 wherein, R 1 , R 2 and R 3 each independently represent a hydrogen atom or an alkoxy group; W 1 and W 2 each independently represent N or CH; X represents O, NR 4 , CONR 4 or NR 4 CO; R 4 represents a hydrogen atom, or an alkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl group; and l, m and n each represents a number of 0 or 1, a salt thereof and a hydrate thereof are provided. These compounds have inhibitory effects on both cell adhesion and cell infiltration and are useful as anti-asthmatic agents, anti-allergic agents, anti-rheumatic agents, anti-arteriosclerotic agents, anti-inflammatory agents, anti-Sjogren's syndrome agents or the like.

  以下是通用公式（1）表示的一个环胺化合物： 其中， R 1 ，R 2 和R 3 分别独立地表示氢原子或烷氧基； W 1 和W 2 分别独立地表示N或CH； X表示O，NR 4 ，CONR 4 或NR 4 CO； R 4 表示氢原子，或烷基，芳基，杂芳基，芳基烷基或杂芳基烷基； l，m和n分别表示0或1的数字， 提供其盐和水合物。 这些化合物对细胞粘附和细胞浸润均具有抑制作用，并可用作抗哮喘剂，抗过敏剂，抗风湿剂，抗动脉硬化剂，抗炎剂，抗干燥综合征剂等。
• CARBINOL DERIVATIVES HAVING HETEROCYCLIC LINKER
  申请人：Koura Minoru

  公开号：US20100280013A1

  公开（公告）日：2010-11-04

  [Object] It is to provide a novel LXRβ agonist useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate: (wherein, each V and W independently show N or C—R 7 ; each X and Y independently show CH 2 , C═O, SO 2 , etc; Z shows CH or N; each R 1 , R 2 and R 7 independently show a hydrogen atom, C 1-8 alkyl group, etc.; R 3 shows C 1-8 alkyl group; R 4 shows an optionally substituted C 6-10 aryl group or an optionally substituted 5- to 11-membered heterocyclic group; R 5 and R 6 show a hydrogen atom, etc.; L shows a C 1-8 alkyl chain optionally substituted with an oxo group, etc.; and n shows any integer of 0 to 2.)

  它是提供一种新型的LXRβ激动剂，可用作预防和/或治疗动脉粥样硬化；动脉硬化，如由糖尿病引起的动脉硬化；血脂异常；高胆固醇血症；与脂质相关的疾病；由炎性细胞因子引起的炎症性疾病；过敏性皮肤病；糖尿病；或阿尔茨海默病的预防和/或治疗剂。【解决手段】由以下一般式（I）表示的羟甲基化合物或其盐，或它们的溶剂化合物： （其中，每个V和W独立地表示N或C—R 7 ；每个X和Y独立地表示CH 2 ，C═O，SO 2 等；Z表示CH或N；每个R 1 ，R 2 和R 7 独立地表示氢原子，C 1-8 烷基基团等；R 3 表示C 1-8 烷基基团；R 4 表示可选择地取代的C 6-10 芳基基团或可选择地取代的5-至11-成员杂环基团；R 5 和R 6 表示氢原子等；L表示可选择地取代有氧基团等的C 1-8 烷基链；n表示0至2的任意整数。】
• NOVEL CONDENSED PYRIDINE OR CONDENSED PYRIMIDINE DERIVATIVE, AND MEDICINAL AGENT COMPRISING SAME
  申请人：Morimoto Toshiharu

  公开号：US20130102621A1

  公开（公告）日：2013-04-25

  The present invention relates to provision of a novel compound that has an activity of promoting insulin secretion from pancreatic β cells and thus is useful as a prophylaxis and/or therapeutic agent for diseases caused by hyperglycemia such as diabetes mellitus, and the compound represented by the following formula (1): wherein one of A and B represents a nitrogen atom and the other represents a nitrogen atom or CR 10 , X represents an oxygen atom, a sulfur atom or —(CH 2 )n-N(R 12 )—, Y represents an oxygen atom, a sulfur atom or —N(R 13 )—, and R 1 to R 9 each represent a hydrogen atom or another substituent, or a salt thereof, or a solvate of the compound or the salt.

  本发明涉及提供一种新型化合物，该化合物具有促进胰岛素从胰岛β细胞分泌的活性，因此可用作预防和/或治疗由高血糖引起的疾病，如糖尿病，所述化合物由以下式（1）表示： 其中A和B中的一个代表氮原子，另一个代表氮原子或CR10，X代表氧原子、硫原子或—(CH2)n-N(R12)—，Y代表氧原子、硫原子或—N(R13)—，R1至R9各自代表氢原子或另一取代基，或其盐，或该化合物或其盐的溶剂化合物。