tert-butyl (1S)-1-(2-(2-hydroxyethyl)cyclopropyl)-3-methylbutylcarbamate | 1205537-01-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl (1S)-1-(2-(2-hydroxyethyl)cyclopropyl)-3-methylbutylcarbamate
• 英文别名: Tert-butyl(1S)-1-(2-(2-hydroxyethyl)cyclopropyl)-3-methylbutylcarbamate；tert-butyl N-[(1S)-1-[2-(2-hydroxyethyl)cyclopropyl]-3-methylbutyl]carbamate
• CAS: 1205537-01-4
• 化学式: C₁₅H₂₉NO₃
• 分子量: 271.4
• InChiKey: GUOYQBQGEWGLTF-BPCQOVAHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl (1S)-1-(2-(2-hydroxyethyl)cyclopropyl)-3-methylbutylcarbamate 在 Jones reagent 作用下， 以 丙酮 为溶剂， 反应 1.0h， 生成 2-(2-((S)-1-((tert-butoxycarbonyl)amino)-3-methylbutyl)cyclopropyl)acetic acid
  参考文献：
  名称：

  INTRAESOPHAGEAL ADMINISTRATION OF TARGETED NITROXIDE AGENTS FOR PROTECTION AGAINST IONIZING IRRADIATION-INDUCED ESOPHAGITIS

  摘要：

  本文提供了一种用于预防或缓解电离辐射诱导的食管炎的组合物和相关方法。这些组合物包括含有与线粒体靶向基团相连的亚硝基含有基团的化合物。这些化合物可以交联成二聚体而不丧失活性。该方法包括向患者输送本文所述的化合物，以有效预防或缓解由辐射引起的食道损伤。

  公开号：

  US20190210969A1
• 作为产物：
  描述：

  (S,E)-8-(tert-butyldiphenylsilyloxy)-2-methyloct-5-en-4-amine hydrochloride 在 palladium 10% on activated carbon 、 四丁基氟化铵 、 氢气 、 diethylzinc 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 乙二醇二甲醚 、 二氯甲烷 、 乙酸乙酯 为溶剂， -20.0~20.0 ℃ 、101.33 kPa 条件下， 反应 65.23h， 生成 tert-butyl (1S)-1-(2-(2-hydroxyethyl)cyclopropyl)-3-methylbutylcarbamate
  参考文献：
  名称：

  INTRAESOPHAGEAL ADMINISTRATION OF TARGETED NITROXIDE AGENTS FOR PROTECTION AGAINST IONIZING IRRADIATION-INDUCED ESOPHAGITIS

  摘要：

  本文提供了一种用于预防或缓解电离辐射诱导的食管炎的组合物和相关方法。这些组合物包括含有与线粒体靶向基团相连的亚硝基含有基团的化合物。这些化合物可以交联成二聚体而不丧失活性。该方法包括向患者输送本文所述的化合物，以有效预防或缓解由辐射引起的食道损伤。

  公开号：

  US20190210969A1

文献信息

• TARGETED NITROXIDE AGENTS
  申请人：Wipf Peter

  公开号：US20100035869A1

  公开（公告）日：2010-02-11

  Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

  本文提供了一种对自由基清除有用的组合物和相关方法，具有特定选择性作用于线粒体。这些化合物包括一个连接到线粒体靶向基团的亚硝基含有基团。这些化合物可以交联成二聚体而不丧失活性。本文还提供了一种用于预防、缓解和治疗辐射引起的损伤的方法。该方法包括向患者输送一种如本文所述的化合物，以有效地预防、缓解或治疗辐射引起的损伤。
• USE OF TARGETED NITROXIDE AGENTS IN PREVENTING, MITIGATING AND TREATING RADIATION INJURY
  申请人：Wipf Peter

  公开号：US20110172214A1

  公开（公告）日：2011-07-14

  Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

  本文提供了一种有用于自由基清除的组合物和相关方法，特别是对线粒体的选择性。该化合物包括连接到线粒体靶向基团的亚硝基含有基团。该化合物可以交联成二聚体而不失去活性。本文还提供了一种方法，用于预防、缓解和治疗放射性损伤。该方法包括将上述所述的化合物以有效的剂量和用药方案输送给患者，以预防、缓解或治疗放射性损伤。
• Targeted nitroxide agents
  申请人：University of Pittsburgh - Of the Commonwealth System of Higher Education

  公开号：US08288551B2

  公开（公告）日：2012-10-16

  Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

  本文提供了一些组合物和相关方法，用于自由基清除，特别具有线粒体选择性。这些化合物包括一个含有亚硝基的基团，连接到一个针对线粒体的基团。这些化合物可以交联成二聚体而不失活性。本文还提供了一种方法，用于预防、缓解和治疗辐射引起的损伤。该方法包括向患者输送上述描述的化合物，以有效的剂量和用药方案预防、缓解或治疗辐射引起的损伤。
• Use of targeted nitroxide agents in mitigating or treating radiation injury
  申请人：Wipf Peter

  公开号：US08822541B2

  公开（公告）日：2014-09-02

  Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

  本文提供了一种有用的自由基清除剂及相关方法，具有对线粒体的特异性选择性。该化合物包括一个连接到线粒体靶向基团的亚硝基含有基团。该化合物可以交联成二聚体而不失活性。本文还提供了一种预防、缓解和治疗辐射引起的损伤的方法。该方法包括将所述化合物以有效的剂量和用药方案输送给患者，以预防、缓解或治疗辐射引起的损伤。
• INTRAESOPHAGEAL ADMINISTRATION OF TARGETED NITROXIDE AGENTS FOR PROTECTION AGAINST IONIZING IRRADIATION-INDUCED ESOPHAGITIS
  申请人：University of Pittsburgh - Of the Commonwealth System of Higher Education

  公开号：US20190210969A1

  公开（公告）日：2019-07-11

  Provided herein are compositions and related methods useful for prevention or mitigation of ionizing radiation-induced esophagitis. The compositions comprise compounds comprising a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent or mitigate esophageal damage caused by radiation.

  本文提供了一种用于预防或缓解电离辐射诱导的食管炎的组合物和相关方法。这些组合物包括含有与线粒体靶向基团相连的亚硝基含有基团的化合物。这些化合物可以交联成二聚体而不丧失活性。该方法包括向患者输送本文所述的化合物，以有效预防或缓解由辐射引起的食道损伤。