N-(7-chloroquinolin-4-yl)alanine | 929077-28-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(7-chloroquinolin-4-yl)alanine
• 英文别名: 2-(7-Chloroquinolin-4-ylamino)-propionic acid；2-[(7-chloroquinolin-4-yl)amino]propanoic acid
• CAS: 929077-28-1
• 化学式: C₁₂H₁₁ClN₂O₂
• mdl: MFCD12414507
• 分子量: 250.685
• InChiKey: XKWDVCNARHNXAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  62.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(7-chloroquinolin-4-yl)alanine 、 cadmium(II) acetate 以 甲醇 、 水 、 乙腈 为溶剂， 生成 ([Cd2(N-(7-chloroquinolin-4-yl)alaninate)4]*3H2O)n
  参考文献：
  名称：

  The architectures of 1D coordination polymers with the versatile 7-chloroquinoline-4-alanine ligand mediated by anions: Syntheses, structures and luminescent properties

  摘要：

  Three new coordination polymers, [Cd(cqaH)(cqa)Cl](n) (1), [Cd(cqaH)(cqa)Br](n) (2) and {[Cd-2(cqa)(4)]center dot 3H(2)O}n (3) (Hcqa = 7-chloroquinolin-4-alanine, cqaH = the Hcqa ligand, where the proton is transferred from the acid group to the imine group) have been prepared under hydrothermal conditions and characterized by X-ray structural analyses. Both complexes 1 and 2 possess 1D ribbon-like chains, and complex 3 features a 1D double-stranded chain. Various coordination fashions and supramolecular networks are observed in complexes 1-3 due to the versatile coordination modes of the ligand and the cooperative effect from anions in the assemblies. In addition, the luminescent properties for all compounds have been investigated in the solid state. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2008.12.059
• 作为产物：
  描述：

  4,7-二氯喹啉 、 L-丙氨酸 、 苯酚 反应 24.0h， 以The title compound is obtained as a white powder (0.2 g, 20%)的产率得到N-(7-chloroquinolin-4-yl)alanine
  参考文献：
  名称：

  Hybrid molecules QA where Q is an aminoquinoline and A is an antibiotic residue, the synthesis and uses thereof as antibacterial agents

  摘要：

  本发明涉及一种氨基喹啉-抗生素杂合物，其一般式为(I)：Q—(Y1)p—(U)p—(Y2)p-A，其中Q代表氨基喹啉，(Y1)p(U)p—(Y2)p″是可选的间隔基，A为抗生素残基。本发明使得抗生素残基的活性得到了意外的增强。

  公开号：

  US20070060558A1