5-(3-chlorophenyl)-1H-imidazol-2-amine | 933726-96-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(3-chlorophenyl)-1H-imidazol-2-amine
• CAS: 933726-96-6
• 化学式: C₉H₈ClN₃
• 分子量: 193.636
• InChiKey: YELBBZBTDDAADY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.7
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2,4-dichlorobenzylidene)acetoacetate methyl ester 、 5-(3-chlorophenyl)-1H-imidazol-2-amine 以 N,N-二甲基甲酰胺 为溶剂， 生成 methyl 2-(3-chlorophenyl)-5-(2,4-dichlorophenyl)-7-methyl-5,8-dihydroimidazo[1,2-a]pyrimidine-6-carboxylate
  参考文献：
  名称：

  Synthesis and SAR of azolopyrimidines as potent and selective dipeptidyl peptidase-4 (DPP4) inhibitors for type 2 diabetes

  摘要：

  Several pyrazolo-, triazolo-, and imidazolopyrimidines were synthesized and evaluated as inhibitors of DPP4. Of these three classes of compounds, the imidazolopyrimidines displayed the greatest potency and demonstrated excellent selectivity over the other dipeptidyl peptidases. SAR evaluation for these scaffolds was described as they may represent potential treatments for type 2 diabetes. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.06.063

文献信息

• Synthesis and SAR of azolopyrimidines as potent and selective dipeptidyl peptidase-4 (DPP4) inhibitors for type 2 diabetes
  作者：Robert P. Brigance、Wei Meng、Aberra Fura、Thomas Harrity、Aiying Wang、Robert Zahler、Mark S. Kirby、Lawrence G. Hamann

  DOI：10.1016/j.bmcl.2010.06.063

  日期：2010.8

  Several pyrazolo-, triazolo-, and imidazolopyrimidines were synthesized and evaluated as inhibitors of DPP4. Of these three classes of compounds, the imidazolopyrimidines displayed the greatest potency and demonstrated excellent selectivity over the other dipeptidyl peptidases. SAR evaluation for these scaffolds was described as they may represent potential treatments for type 2 diabetes. (C) 2010 Elsevier Ltd. All rights reserved.