1,1,1,2,2-pentafluorododecan-3-ol

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: 1,1,1,2,2-pentafluorododecan-3-ol
• 化学式: C₁₂H₂₁F₅O
• 分子量: 276.29
• InChiKey: YFCKZQQCWZNEFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,1,1,2,2-pentafluorododecan-3-ol 在 4-二甲氨基吡啶 、 三乙酰氧基硼氢化钠 、 溶剂黄146 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 、 1,2-二氯乙烷 为溶剂， 生成 Bis(1,1,1,2,2-pentafluorododecan-3-yl) 10-[3-(dimethylamino)propylamino]nonadecanedioate
  参考文献：
  名称：

  [EN] FLUORINATED CATIONIC LIPIDS FOR USE IN LIPID NANOPARTICLES
  [FR] LIPIDES CATIONIQUES FLUORÉS DESTINÉS À ÊTRE UTILISÉS DANS DES NANOPARTICULES LIPIDIQUES

  摘要：

  Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R2a, R2b, R3a, R3b, R7, R8, R9, L1, L2, G1, G2, G3, b, and c are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

  公开号：

  WO2023114944A1

文献信息

• Solid state NMR spectroscopy/imaging in situ measuring devices and methods for calibration and determining one or more quantitative properties of a target sample
  申请人：The Curators of the University of Missouri

  公开号：US10067079B2

  公开（公告）日：2018-09-04

  In situ measuring devices, methods of making the same, and methods of using the same are provided herein. The in situ measuring devices can include a capillary tube having a reference material sealed inside the capillary tube, where the capillary tube is positioned inside of a solid state or MAS NMR rotor. A target sample can also be positioned in the interior of the solid state or MAS NMR rotor but is sequestered from the reference material by a capillary tube wall. The in situ measuring devices can be used in solid state MAS NMR spectroscopy to quantify one or more parameters of a target sample, such as the quantity of a sample, chemical identity of a sample, or temperature of a sample.

  本文提供了原位测量装置、制造方法和使用方法。原位测量装置可包括一个毛细管，毛细管内密封有参比材料，毛细管位于固态或 MAS NMR 转子的内部。目标样品也可置于固态或 MAS NMR 转子的内部，但通过毛细管壁与参比材料隔离。原位测量装置可用于固态 MAS NMR 光谱分析，以量化目标样品的一个或多个参数，例如样品的数量、样品的化学特性或样品的温度。
• In situ NMR parameter monitoring systems and methods for measuring pH and temperature
  申请人：The Curators of the University of Missouri

  公开号：US10295487B2

  公开（公告）日：2019-05-21

  Devices and methods are provided for measuring temperatures and pHs of a sample in situ using NMR spectroscopy, and for sealing one or more ends of a capillary tube after a reference material has been added to the capillary tube, which is used in an in situ NMR temperature measurement device. A method for measuring a pH of a sample in situ using NMR spectroscopy includes providing an in situ NMR pH measurement device. This device includes a sample housing member configured to house a target sample, at least one pH sensor configured to exhibit an NMR spectral change due to a change in pH value of the target sample, and a pH sensor containment member configured to house the at least one pH sensor. The target sample is added to the sample housing member. NMR spectra are obtained to then determine the pH of the target sample.

  提供了利用核磁共振光谱原位测量样品温度和 pH 值的装置和方法，以及在毛细管中加入参比材料后密封毛细管一端或多端的装置和方法，毛细管用于原位核磁共振温度测量装置。使用核磁共振光谱原位测量样品 pH 值的方法包括提供一种原位核磁共振 pH 值测量装置。该装置包括一个配置为容纳目标样品的样品容纳部件、至少一个配置为因目标样品的 pH 值变化而显示 NMR 光谱变化的 pH 传感器，以及一个配置为容纳至少一个 pH 传感器的 pH 传感器容纳部件。将目标样品添加到样品容纳部件中。获得 NMR 光谱，然后确定目标样品的 pH 值。
• SOLID STATE NMR SPECTROSCOPY/IMAGING IN SITU MEASURING DEVICES AND METHODS FOR CALIBRATION AND DETERMINING ONE OR MORE QUANTITATIVE PROPERTIES OF A TARGET SAMPLE
  申请人：The Curators of the University of Missouri

  公开号：US20160109391A1

  公开（公告）日：2016-04-21

  In situ measuring devices, methods of making the same, and methods of using the same are provided herein. The in situ measuring devices can include a capillary tube having a reference material sealed inside the capillary tube, where the capillary tube is positioned inside of a solid state or MAS NMR rotor. A target sample can also be positioned in the interior of the solid state or MAS NMR rotor but is sequestered from the reference material by a capillary tube wall. The in situ measuring devices can be used in solid state MAS NMR spectroscopy to quantify one or more parameters of a target sample, such as the quantity of a sample, chemical identity of a sample, or temperature of a sample.
• In Situ NMR Parameter Monitoring Systems and Methods for Measuring PH and Temperature
  申请人：The Curators of the University of Missouri

  公开号：US20160109390A1

  公开（公告）日：2016-04-21

  Devices and methods are provided for measuring temperatures and pHs of a sample in situ using NMR spectroscopy, and for sealing one or more ends of a capillary tube after a reference material has been added to the capillary tube, which is used in an in situ NMR temperature measurement device. A method for measuring a pH of a sample in situ using NMR spectroscopy includes providing an in situ NMR pH measurement device. This device includes a sample housing member configured to house a target sample, at least one pH sensor configured to exhibit an NMR spectral change due to a change in pH value of the target sample, and a pH sensor containment member configured to house the at least one pH sensor. The target sample is added to the sample housing member. NMR spectra are obtained to then determine the pH of the target sample.
• [EN] SOLID STATE NMR SPECTROSCOPY/IMAGING IN SITU MEASURING DEVICES<br/>[FR] DISPOSITIFS DE MESURE IN SITU DE SPECTROSCOPIE/IMAGERIE RMN À SEMI-CONDUCTEURS
  申请人：UNIV MISSOURI

  公开号：WO2017083665A1

  公开（公告）日：2017-05-18

  In situ measuring devices, methods of making the same, and methods of using the same are provided herein. The in situ measuring devices can include a capillary tube having a reference material sealed inside the capillary tube, where the capillary tube is positioned inside of a solid state or MAS NMR rotor. A target sample can also be positioned in the interior of the solid state or MAS NMR rotor but is sequestered from the reference material by a capillary tube wall. The in situ measuring devices can be used in solid state MAS NMR spectroscopy to quantify one or more parameters of a target sample, such as the quantity of a sample, chemical identity of a sample, or temperature of a sample.