4-hydroxy-2-methylindoline | 849148-80-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-hydroxy-2-methylindoline
• 英文别名: 2-Methyl-2,3-dihydro-1H-indol-4-ol
• CAS: 849148-80-7
• 化学式: C₉H₁₁NO
• mdl: MFCD19225981
• 分子量: 149.192
• InChiKey: XOJUZGWOQMIMHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-羟基-2-甲基吲哚 在 sodium cyanoborohydride 、 溶剂黄146 作用下， 反应 1.75h， 以0.87 g的产率得到4-hydroxy-2-methylindoline
  参考文献：
  名称：

  NOVEL PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS

  摘要：

  本发明涉及从嘧啶衍生的新化合物，以及制备该化合物的方法，获得的新中间体，将其用作药物的用途，含有该化合物的药物组合物，以及将其作为AKT抑制剂的治疗用途。

  公开号：

  US20130274253A1

文献信息

• Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors
  申请人：Chang Han-Ting

  公开号：US20070135385A1

  公开（公告）日：2007-06-14

  Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.

  吲哚和与吲哚相关的化合物、组合物以及方法被披露。发明中的这些化合物作为磷脂酶抑制剂非常有用。发明中的这些化合物和组合物用于治疗动物受试者中的磷脂酶相关状况，例如胰岛素相关、体重相关和/或胆固醇相关状况。
• NOVEL PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS
  申请人：Brollo Maurice

  公开号：US20130274253A1

  公开（公告）日：2013-10-17

  The present invention relates to novel chemical compounds derived from pyrimidines, to the method for preparing same, to the novel intermediates obtained, to the use thereof as drugs, to the pharmaceutical compositions containing same, and to the therapeutic use thereof as AKT inhibitors.

  本发明涉及从嘧啶衍生的新化合物，以及制备该化合物的方法，获得的新中间体，将其用作药物的用途，含有该化合物的药物组合物，以及将其作为AKT抑制剂的治疗用途。
• Enhanced reactivity in OH/NH/? polyfunctional systems through coupled proton/electron transfer in the excited state: the photocyclisation of 2-allyl-3-aminophenol
  作者：Edgar A. Leo、Rosa Tormos、Miguel A. Miranda

  DOI：10.1039/b416625f

  日期：——

  The photocyclisation rate of 2-allyl-3-(or 5-)aminophenols (1, 4 and 8) is dramatically enhanced, when compared with reference compounds, as a consequence of a coupled proton/electron transfer process.

  与参考化合物相比，2-烯丙基-3-（或 5-）氨基苯酚（1、4 和 8）的光环化速率显着提高，这是耦合质子/电子转移过程的结果。
• Phospholipase inhibitors, including multi-valent phospholipase inhibitors, and use thereof, including as lumen-localized phospholipase inhibitors
  申请人：Chang Han-Ting

  公开号：US20070135383A1

  公开（公告）日：2007-06-14

  The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in a gastrointestinal lumen.

  本发明提供了治疗磷脂酶相关疾病的方法和组合物。具体地，本发明提供了一种用于治疗动物主体中的胰岛素相关、体重相关和/或胆固醇相关疾病的方法。该方法通常涉及在胃肠道腔中定位的非吸收和/或外流的磷脂酶A2抑制剂的给药。
• INDOLE COMPOUNDS HAVING C4-AMIDE SUBSTITUENTS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS
  申请人：Chang Han-Ting

  公开号：US20090306171A1

  公开（公告）日：2009-12-10

  Indole and indole-related compounds according to the formula (I) or (II) optionally having additional heteroatoms, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject. Formula (I), formula (II). R 4 being a moiety represented by formula (C4-II-C), R 3 being a moiety represented by formula (C3-I or C3-II).

  本发明揭示了具有公式（I）或（II）的吲哚和吲哚相关化合物，可选择具有额外杂原子，以及组合物和方法。本发明的化合物可用作磷脂酶抑制剂。本发明的化合物和组合物可用于治疗磷脂酶相关疾病，例如动物体内的胰岛素相关、体重相关和/或胆固醇相关疾病。其中，公式（I）和公式（II）中，R4是由公式（C4-II-C）表示的基团，R3是由公式（C3-I或C3-II）表示的基团。