7-fluoro-4-methyl-4,5-dihydropyrrolo[1,2-a]quinoline | 1632149-06-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-fluoro-4-methyl-4,5-dihydropyrrolo[1,2-a]quinoline
• 英文别名: 7-Fluoro-4-methyl-4,5-dihydropyrrolo[1,2-a]quinoline
• CAS: 1632149-06-4
• 化学式: C₁₃H₁₂FN
• 分子量: 201.243
• InChiKey: ZFCQCEWNBIHRHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-烯丙基-4-氟苯胺 在 硫酸 、 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 反应 2.67h， 生成 7-fluoro-4-methyl-4,5-dihydropyrrolo[1,2-a]quinoline
  参考文献：
  名称：

  1-(2-Allylaryl)-1H-pyrroles as Building Blocks for Novel 4-Methyl-4,5-di­hydropyrrolo[1,2-a]quinoline Derivatives

  摘要：

  Novel substituted 4-methyl-4,5-dihydropyrrolo[1,2-a]-quinolines were prepared by a simple two-step approach involving a Clauson-Kaas reaction of a substituted ortho-allylaniline followed by acid-catalyzed regioselective intramolecular Friedel-Crafts alkylation of the resulting 1-(2-allylaryl)-1H-pyrroles. All the synthetized compounds were fully characterized by IR, H-1 and C-13 NMR spectroscopy, and mass spectrometry.

  DOI：

  10.1055/s-0033-1340217

文献信息

• 1-(2-Allylaryl)-1H-pyrroles as Building Blocks for Novel 4-Methyl-4,5-di­hydropyrrolo[1,2-a]quinoline Derivatives
  作者：Alirio Palma、Julio Orejarena、Sandra Gómez、Justo Cobo、Manuel Nogueras

  DOI：10.1055/s-0033-1340217

  日期：——

  Novel substituted 4-methyl-4,5-dihydropyrrolo[1,2-a]-quinolines were prepared by a simple two-step approach involving a Clauson-Kaas reaction of a substituted ortho-allylaniline followed by acid-catalyzed regioselective intramolecular Friedel-Crafts alkylation of the resulting 1-(2-allylaryl)-1H-pyrroles. All the synthetized compounds were fully characterized by IR, H-1 and C-13 NMR spectroscopy, and mass spectrometry.