9-carbomethoxy-9-(2,3,5,6-tetrafluoropyrid-4-yl)fluorene | 121721-35-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9-carbomethoxy-9-(2,3,5,6-tetrafluoropyrid-4-yl)fluorene
• 英文别名: methyl 9-(tetrafluoropyridin-4-yl)fluorene-9-carboxylate；9-methoxycarbonyl-9-(2,3,5,6-tetrafluoropyrid-4-yl)fluorene；Methyl 9-(2,3,5,6-tetrafluoropyridin-4-yl)fluorene-9-carboxylate
• CAS: 121721-35-5
• 化学式: C₂₀H₁₁F₄NO₂
• 分子量: 373.306
• InChiKey: ZIQUJBIOLAPNJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  五氟吡啶 、 9-methoxycarbonylfluorene potassium salt 以 四氢呋喃 为溶剂， 生成 9-carbomethoxy-9-(2,3,5,6-tetrafluoropyrid-4-yl)fluorene
  参考文献：
  名称：

  Carbonylmetallates and carbanions in aromatic and vinylic nucleophilic substitution

  摘要：

  The kinetic data on the reactions of carbonylmetallates M'M(CO)(n)L(m), with polyfluorinated arenes and alkenes are reported. The behaviour of these transition metal anionic nucleophiles is compared with the reactivity of both carbanions, and non-transition metal centred anions.

  DOI：

  10.1002/(sici)1099-1395(199606)9:6<319::aid-poc786>3.0.co;2-7

文献信息

• Artamkina, G. A.; Beletskaya, I. P., Russian Journal of Organic Chemistry, 1995, vol. 31, # 7, p. 969 - 972
  作者：Artamkina, G. A.、Beletskaya, I. P.

  DOI：——

  日期：——
• Effect of nature of the nucleophile on the mechanism of nucleophilic aromatic substitution reactions involving fluorenyl and trimethylstannyl anions
  作者：G. A. Artamkina、A. Yu. Mil'chenko、I. P. Beletskaya、O. A. Reutov

  DOI：10.1007/bf00952638

  日期：1988.12
• ——
  作者：I.A. Os'kina、V.M. Vlasov

  DOI：10.1023/a:1012391231937

  日期：——

  Rate constants of reactions between sodium salts of diarylamines N-anions and hexafluorobenzene and pentafluoropyridine in DMSO at 25 degreesC were determined. The Bronsted factors for substrates under consideration are 0.14 and 0.34 respectively. These data evidence a considerable effect of substrate electrophilicity on the reactivity of diarylamines N-anions in the SNAr reactions. Deviations of the Bronsted plot from linearity for the reactions of hexafluorobenzene with aryl-and diarylamines N-anions may be due to the difference in internal barriers of these reactions.