1,3-bis(azidomethyl)-2-methoxy-5-methylbenzene | 203450-31-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,3-bis(azidomethyl)-2-methoxy-5-methylbenzene
• CAS: 203450-31-1
• 化学式: C₁₀H₁₂N₆O
• 分子量: 232.245
• InChiKey: GGZJPLORDTXODM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  38
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,3-bis(azidomethyl)-2-methoxy-5-methylbenzene 在 水 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 以90%的产率得到
  参考文献：
  名称：

  Water-Soluble Class C β-Lactamase Catalytic Residue Mimic: Effect of Proximally Positioned Functional Groups on their pKa Values

  摘要：

  Molecules mimicing class C beta-lactamase catalytic residues were synthesized to study the effect of proximal positioning of serine, lysine and tyrosine side chains on their pKa values. The three amino acid side chains were mimicked by hydroxymethyl group, alkyl ammonium group and phenol which were linked by a short skeleton to ensure interaction among these functionalities. Comparison of the mimics in water showed a phenolic pKa decrease of up to 3.6 units. The finding supports the possible role of tyrosine as a general acid/base catalyst in acylation of class C beta-lactamase. (C) 1997 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(97)10486-5
• 作为产物：
  描述：

  2-羟基-5-甲基间苯二甲醇 在 氯化亚砜 、 sodium azide 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 反应 26.0h， 生成 1,3-bis(azidomethyl)-2-methoxy-5-methylbenzene
  参考文献：
  名称：

  Water-Soluble Class C β-Lactamase Catalytic Residue Mimic: Effect of Proximally Positioned Functional Groups on their pKa Values

  摘要：

  Molecules mimicing class C beta-lactamase catalytic residues were synthesized to study the effect of proximal positioning of serine, lysine and tyrosine side chains on their pKa values. The three amino acid side chains were mimicked by hydroxymethyl group, alkyl ammonium group and phenol which were linked by a short skeleton to ensure interaction among these functionalities. Comparison of the mimics in water showed a phenolic pKa decrease of up to 3.6 units. The finding supports the possible role of tyrosine as a general acid/base catalyst in acylation of class C beta-lactamase. (C) 1997 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(97)10486-5

文献信息

• Click estradiol dimers with novel aromatic bridging units: synthesis and anticancer evaluation
  作者：Jiří Řehulka、Michal Jurášek、Pavel Dráber、Aleksandra Ivanová、Soňa Gurská、Kateřina Ječmeňová、Olena Mokshyna、Marián Hajdúch、Pavel Polishchuk、Pavel B. Drašar、Petr Džubák

  DOI：10.1080/14756366.2024.2367139

  日期：2024.12.31

  Estradiol dimers (EDs) possess significant anticancer activity by targeting tubulin dynamics. In this study, we synthesised 12 EDs variants via copper-catalysed azide-alkyne cycloaddition (CuAAC) r...

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• IONIC CONDUCTOR, PROCESS FOR PRODUCTION THEREOF, AND ELECTROCHEMICAL DEVICE
  申请人：Hinokuma Koichiro

  公开号：US20070092800A1

  公开（公告）日：2007-04-26

  Disclosed herein are an ionic conductor including a proton conductor, a process for production thereof, and an electrochemical device (such as fuel cell) with said ionic conductor, said ionic conductor being superior in ionic conductivity, water resistance, and film forming properties. The ionic conductor is formed from a polymer in which carbon clusters having ion dissociating functional groups are bonded to each other through connecting groups. The polymer is less water-soluble and more chemically stable than a derivative composed solely of carbon clusters; therefore, it permits many ion dissociating functional group to be introduced thereinto. Moreover, if ion dissociating functional groups are introduced into also the connecting group, it is possible to prevent the concentration of ion dissociating functional groups from decreasing as the result of polymerization. The polymer can be easily synthesized by simple condensation, substitution, and hydrolysis. Therefore, the process is suitable for mass production in high yields.
• US7651803B2
  申请人：——

  公开号：US7651803B2

  公开（公告）日：2010-01-26
• US7771891B2
  申请人：——

  公开号：US7771891B2

  公开（公告）日：2010-08-10